VR panorama, or virtual reality, has become a new medium for mass media. Its collection of special technical hardware including computers, head-mounted displays, headphones, and motion-sensitive gloves has been widely used in various fields. The purpose of this article is to study a non-contact VR video image measurement system that can be used for cell strain measurement and mechanical property characterization. In this paper, through the extraction of cell feature points, as well as cell morphology processing and image graying, etc. The observed static cells exhibit dynamics. Under the example test of the protein elastic deformation measurement experiment in the cell nucleus and the mechanical characterization experiment of the cell hardness measurement, it is concluded that the percentage of the volume strain change of the cell is about The result of the shear strain change percentage is about 4 times, and the maximum relative error of the image measurement system is 2.36%, which indicates that the measurement of the VR video image measurement system in this paper is feasible and effective. It better solves the shortcomings of current cell observation and measurement, and can be applied to modern biological development or medical research with more excellent technology.