Beyond 2D: 3D bioprinting for skin regeneration

Wang, Rui; Wang, Yihui; Yao, Bin; Hu, Tian; Zhao, Li; Huang, Sha; Fu, Xiaobing

doi:10.1111/iwj.13003

Cited by 36 publications

(28 citation statements)

References 50 publications

(156 reference statements)

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“…This process supports a recovering wound upon local maturation [46]. Several types of bioprinting technology have been used to prepare 3D-skin, such as laser-assisted [47], micro-extrusion [48], and inkjet bioprinting [49]. To facilitate the 3D printed skin process, a range of natural biomaterials like cellulose [47], alginate [50], GelMA-collagen [51], hydrogels [52], keratinocytes (KCs) [48], fibroblasts (FBs) [48], carbon nanotubes [53], and others have been employed.…”

Section: Skinmentioning

confidence: 98%

“…Several types of bioprinting technology have been used to prepare 3D-skin, such as laser-assisted [47], micro-extrusion [48], and inkjet bioprinting [49]. To facilitate the 3D printed skin process, a range of natural biomaterials like cellulose [47], alginate [50], GelMA-collagen [51], hydrogels [52], keratinocytes (KCs) [48], fibroblasts (FBs) [48], carbon nanotubes [53], and others have been employed. The availability of suitable biomaterials and technology advancement has resulted in bioprinting being used successfully to fabricate 3D-skin [47].…”

Section: Skinmentioning

confidence: 99%

See 1 more Smart Citation

Challenges of 3D printing technology for manufacturing biomedical products: A case study of Malaysian manufacturing firms

Shahrubudin

Koshy

Alipal

et al. 2020

Heliyon

104

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Additive manufacturing has attracted increasing attention worldwide, especially in the healthcare, biomedical, aerospace, and construction industries. In Malaysia, insufficient acceptance of this technology by local industries has resulted in a call for government and local practitioners to promulgate the development of this technology for various industries, particularly for biomedical products. The current study intends to frame the challenges endured by biomedical industries who use 3D printing technology for their manufacturing processes. Qualitative methods, particularly in-depth interviews, were used to identify the challenges faced by manufacturing firms when producing 3D printed biomedical products. This work was able to identify twelve key challenges when deploying additive manufacturing in biomedical products and these include issues related to binder selection, poor mechanical properties, low-dimensional accuracy, high levels of powder agglomeration, nozzle size, distribution size, limited choice of materials, texture and colour, lifespan of materials, customization of fit and design, layer height, and, lastly, build-failure. Furthermore, there also are six challenges in the management of manufacturing biomedical products using 3D printing technology, and these include staff re-education, product pricing, limited guidelines, cyber-security issues, marketing, and patents and copyright. This study discusses the reality faced by 3D printing players when producing biomedical products in Malaysia, and presents a primary reference for practitioners in other developing countries.

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Section: Skinmentioning

confidence: 98%

Section: Skinmentioning

confidence: 99%

Challenges of 3D printing technology for manufacturing biomedical products: A case study of Malaysian manufacturing firms

Shahrubudin

Koshy

Alipal

et al. 2020

Heliyon

104

View full text Add to dashboard Cite

show abstract

“…The skin performs fundamental functions like maintaining homeostasis (regulating the body temperature through sweat) and the protection of the internal organs from the outside environment. [33] Moreover, this organ has the capability of self-healing and renewal. It includes three different layers: epidermis, dermis and hypodermis (Figure 1).…”

Section: Skin Anatomy and Histologymentioning

confidence: 99%

The Application of Mesenchymal Stem Cells on Wound Repair and Regeneration

Lopes¹,

Sousa²,

Alvites³

et al. 2021

Preprint

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In the past decades, regenerative medicine applied on skin lesions has been a field of constant improvement for both human and veterinary medicine. The process of healing cutaneous wound injuries implicates a well-organized cascade of molecular and biological processes. However, sometimes the normal process fails and can result in a chronic lesion. In addition, wounds are considered an increasing clinical impairment, due to the progressive ageing of the population, as well as the prevalence of concomitant diseases, such as diabetes and obesity, that represent risk aggravating factors for the development of chronic skin lesions. Stem cells regenerative potential has been recognized worldwide, including towards skin lesion repair, Tissue engineering techniques have long been successfully associated with stem cell therapies, namely the application of 3D bioprinted scaffolds. With this review we intend to explore several stem cell sources with promising aptitude towards skin regeneration, as well as different techniques used to deliver those cells and provide a supporting extracellular matrix environment, with effective outcomes. Furthermore, different studies are discussed, both in vitro and in vivo, towards their relevance in the skin regeneration field.

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“…Wound healing involves the complex, highly integrated and overlapping events of hemostasis, inflammation, migration, proliferation and maturation [ 5 , 6 ]. However, damage to skin tissue from high-impact trauma may result in inadequate self-repair and the need for clinical interventions [ 7 ]. Current clinical treatments to support wound repair and regeneration include autografts [ 8 ], allografts [ 9 ], skin substitute [ 10 ], cell therapy [ 11 ] and cytokine therapy [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Advances in the Research of Bioinks Based on Natural Collagen, Polysaccharide and Their Derivatives for Skin 3D Bioprinting

Zheng

et al. 2020

Polymers

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The skin plays an important role in protecting the human body, and wound healing must be set in motion immediately following injury or trauma to restore the normal structure and function of skin. The extracellular matrix component of the skin mainly consists of collagen, glycosaminoglycan (GAG), elastin and hyaluronic acid (HA). Recently, natural collagen, polysaccharide and their derivatives such as collagen, gelatin, alginate, chitosan and pectin have been selected as the matrix materials of bioink to construct a functional artificial skin due to their biocompatible and biodegradable properties by 3D bioprinting, which is a revolutionary technology with the potential to transform both research and medical therapeutics. In this review, we outline the current skin bioprinting technologies and the bioink components for skin bioprinting. We also summarize the bioink products practiced in research recently and current challenges to guide future research to develop in a promising direction. While there are challenges regarding currently available skin bioprinting, addressing these issues will facilitate the rapid advancement of 3D skin bioprinting and its ability to mimic the native anatomy and physiology of skin and surrounding tissues in the future.

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Beyond 2D: 3D bioprinting for skin regeneration

Cited by 36 publications

References 50 publications

Challenges of 3D printing technology for manufacturing biomedical products: A case study of Malaysian manufacturing firms

Challenges of 3D printing technology for manufacturing biomedical products: A case study of Malaysian manufacturing firms

The Application of Mesenchymal Stem Cells on Wound Repair and Regeneration

Advances in the Research of Bioinks Based on Natural Collagen, Polysaccharide and Their Derivatives for Skin 3D Bioprinting

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