Growing urban population and contemporary urban systems lock-in unsustainable urban development pathways, deteriorating the living quality of urban dwellers. The systemic complexity of these challenges renders it difficult to find solutions using existing planning processes. Alternatively, transformative planning processes are radical, take place on multiple scales, and are often irreversible; therefore, require the integration of local stakeholders’ perspectives, which are often contradictory. We identify perceived levers of urban transformative change using a serious game to facilitate the integration of these perspectives through simulating neighbourhood transformation processes in two European case studies. Building on existing transformation frameworks, we organize, conceptualize, and compare the effectiveness of these levers through demonstrating their interactions with different scales of transformation. Specifically, drawing from close commonalities between large-scale (Three Spheres of Transformation) and place-based (Place-making) transformation frameworks, we show how these interactions can help to develop recommendations to unlock urban transformative change. Results show that access to participation is a key lever enabling urban transformative change. It appears to be mid-level effective to unlock urban transformative change through interactions with the political sphere of transformation and procedural element of Place-making. Ultimately, however, most effective are those levers that interact with all scales of transformation. For example, by engaging a combination of levers including access to participation, public spaces, parking, place-characteristics and place-identity. These findings could be operationalized by self-organized transformation processes focused on repurposing hard infrastructure into public spaces, whilst ensuring continuity of place-based social- and physical features. Local stakeholders could further use such processes to better understand and engage with their individual roles in the transformative process, because interactions with the personal scale, i.e., personal sphere of transformation appear paramount to unlock urban transformative change.