Beyond binary parcellation of the vestibular cortex – A dataset

Kirsch, V.; Boegle, Rainer; Keeser, Daniel; Kierig, E.; Ertl‐Wagner, Birgit; Brandt, Thomas; Dieterich, Marianne

doi:10.1016/j.dib.2019.01.014

Cited by 5 publications

(6 citation statements)

References 9 publications

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“…Data from each participant were collected in two randomly ordered sessions of DC-GVS paradigms of cathode on the right and anode on the left (CRAL) or cathode on the left and anode on the right (CLAR; Tables 1, 2). The experimental design using "CLAR and CRAL" in right-handed participants is required in the context of handedness-dependent vestibular lateralization, in which the vestibular input and signaling pathways from the dominant side are more predominant than those from the non-dominant side (35,36). This allowed the detection of any difference in the GVS threshold between CLAR and CRAL models.…”

Section: Experimental Design and Gvs Proceduresmentioning

confidence: 99%

Thresholds for vestibular and cutaneous perception and oculomotor response induced by galvanic vestibular stimulation

Nguyen

Kang

2022

Front. Neurol.

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ObjectivesIn this study, the specific threshold intensities and response characteristics of galvanic vestibular stimulation (GVS) on vestibular (conscious) and cutaneous (detrimental) perception as well as oculomotor nystagmus (reflex) were determined.MethodsThe threshold intensities for vestibular and cutaneous perception and oculomotor response induced by GVS were determined in 25 right-handed healthy subjects (32.6 ± 7.2 years of age; 56% female). The subjects were seated upright, and eye movements were recorded while a direct GVS current was applied with paradigms of cathode on the right and anode on the left (CRAL) and also cathode on the left and anode on the right (CLAR).ResultsSubjects experienced dizziness, sense of spinning, or fall tendency, which was more frequently directed to the cathode (76%) than the anode (24%, p < 0.001, chi-square one-variable test) at mean current greater than 0.98 ± 0.29 mA (mean vestibular threshold). The current also triggered a more frequent mild tingling sensation at the cathode (56%) than the anode (30%) or on both sides (14%; p = 0.001, chi-square one-variable test) when above the mean cutaneous threshold of 0.9 ± 0.29 mA. Above the mean oculomotor threshold of 1.61 ± 0.35 mA, combined horizontal and torsional nystagmus was more frequent toward the cathode (86%) than toward the anode (p < 0.001, chi-square one-variable test). The mean oculomotor threshold was significantly higher than both the vestibular (p < 0.001, Mann–Whitney U-test) and cutaneous (p < 0.001, Mann–Whitney U-test) thresholds, which were comparable (p = 0.317, Mann–Whitney U-test). There was no significant disparity in these specific thresholds between the two GVS paradigms. The vestibular threshold was significantly higher in males than in females [1 (0.5–1.25) mA vs. 0.75 (0.625–1.125) mA, Z = −2.241, p = 0.025, Mann–Whitney U-test]. However, the thresholds of cutaneous perception and oculomotor response did not differ by sex.ConclusionThe findings indicate that thresholds for vestibular and somatosensory perception are lower than the oculomotor threshold. Therefore, a strategy to reduce GVS current intensity to the level of vestibular or somatosensory perception threshold could elicit beneficial vestibular effects while avoiding undesirable effects such as oculomotor consequences.

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Section: Experimental Design and Gvs Proceduresmentioning

confidence: 99%

Thresholds for vestibular and cutaneous perception and oculomotor response induced by galvanic vestibular stimulation

Nguyen

Kang

2022

Front. Neurol.

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“…As the vestibular system is lateralized (Dieterich et al, 2003), the right cathode might have a more preponderant effect on the vestibular system in the righthanded participants. Although this is only a hypothesis, it rests on previous data (Fink et al, 2003) showing that the right and left cathode stimulation activated different parts of the brain in right-handed participants and that different regions are activated by GVS in right-and left-handers (Kirsch et al, 2018). A similar asymmetry could occur caudally in vestibular projections to the spinal cord, which would lead to more dominant responses when the cathode is on the right side.…”

Section: Significant Effect Of Rcathode Gvs On Gait Cycle Durationmentioning

confidence: 57%

Effect of galvanic vestibular stimulation applied at the onset of stance on muscular activity and gait cycle duration in healthy individuals

Abbariki

Mikhail²,

Hamadjida³

et al. 2023

Front. Neural Circuits

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Locomotion requires the complex involvement of the spinal and supraspinal systems. So far, the role of vestibular input in gait has been assessed mainly with respect to gait stability. The noninvasive technique of galvanic vestibular stimulation (GVS) has been reported to decrease gait variability and increase gait speed, but the extent of its effect on spatiotemporal gait parameters is not fully known.Objective: Characterize vestibular responses during gait and determine the influence of GVS on cycle duration in healthy young participants.Methods: Fifteen right-handed individuals participated in the study. Electromyography (EMG) recordings of the bilateral soleus (SOL) and tibialis anterior muscles (TA) were performed. First, to determine stimulation intensity, an accelerometer placed on the vertex recorded the amplitude of the head tilts evoked by the GVS (1–4 mA, 200 ms) to establish a motor threshold (T). Second, while participants walked on a treadmill, GVS was applied at the onset of the stance phase during the treadmill gait with an intensity of 1 and 1.5 T with the cathode behind the right (RCathode) or left ear (LCathode). EMG traces were rectified, averaged (n = 30 stimuli), and analyzed. Latency, duration, and amplitude of vestibular responses as well as the mean duration of the gait cycles were measured.Results: GVS mainly induced long-latency responses in the right SOL, right TA and left TA. Only short-latency responses were triggered in the left SOL. Responses in the right SOL, left SOL and left TA were polarity dependent, being facilitatory with RCathode and inhibitory with LCathode, whereas responses in the right TA remained facilitatory regardless of the polarity. With the RCathode configuration, the stimulated cycle was prolonged compared with the control cycle at both 1 and 1.5 T, due to prolonged left SOL and TA EMG bursts, but no change was observed in right SOL and TA. With LCathode, GVS did not modify the cycle duration.Conclusion: During gait, a brief, low-intensity GVS pulse delivered at the right stance onset induced mainly long-latency polarity-dependent responses. Furthermore, a RCathode configuration increased the duration of the stimulated gait cycle by prolonging EMG activity on the anodic side. A similar approach could be explored to influence gait symmetry in individuals with neurological impairment.

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“…The data used in this study were partly published previously [8,9]. The data on the morphology of the inner ear are unpublished data.…”

Section: Methodsmentioning

confidence: 99%

“…All acquired images in DICOM format were converted to the NifTI-file format (using MRICron dcm2nii) and preprocessed using the SPM12 software package, DARTEL (Diffeomorphic Anatomical Registration Through Exponentiated Lie algebra; [13,14]) and CONN functional connectivity toolbox v15 [15]. Further denoising using wholebrain ICA as well as dual regression as implemented in the FSL toolbox MELODIC [16,17], and scripts in MATLAB (MathWorks Inc., Natick, MA, USA) were applied as previously described in [8,9,18]. No participants were discarded due to motion artifacts.…”

Section: Fmri Data Processingmentioning

confidence: 99%

“…Six regions of interest (ROIs) were selected based on results from two previous studies [4,5] as well as symmetry considerations, as the vestibular system has distinct lateralization properties related to handedness [4,5,8,9,20,21]. The two previous MVS studies [4,5] had found MVS modulations in the default mode network (DMN) and a visual network called the "higher visual network" (hVN) in the scaling relationship of RS-fMRI fluctuations in 1.5 T and 3.0 T. Here these ROIs serve as areas for testing whether RS-fMRI fluctuations are dependent on the different orientations of the inner ears, as these areas were previously found to be MVS sensitive.…”

Section: Regions Of Interestmentioning

confidence: 99%

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Modulatory effects of magnetic vestibular stimulation on resting-state networks can be explained by subject-specific orientation of inner-ear anatomy in the MR static magnetic field

et al. 2020

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Strong static magnetic fields, as used in magnetic resonance imaging (MRI), stimulate the vestibular inner ear leading to a state of imbalance within the vestibular system that causes nystagmus. This magnetic vestibular stimulation (MVS) also modulates fluctuations of resting-state functional MRI (RS-fMRI) networks. MVS can be explained by a Lorentz force model, indicating that MVS is the result of the interaction of the static magnetic field strength and direction (called “B0 magnetic field” in MRI) with the inner ear’s continuous endolymphatic ionic current. However, the high variability between subjects receiving MVS (measured as nystagmus slow-phase velocity and RS-fMRI amplitude modulations) despite matching head position, remains to be explained. Furthermore, within the imaging community, an “easy-to-acquire-and-use” proxy accounting for modulatory MVS effects in RS-fMRI fluctuations is needed. The present study uses MRI data of 60 healthy volunteers to examine the relationship between RS-fMRI fluctuations and the individual orientation of inner-ear anatomy within the static magnetic field of the MRI. The individual inner-ear anatomy and orientation were assessed via high-resolution anatomical CISS images and related to fluctuations of RS-fMRI networks previously associated with MVS. More specifically, we used a subject-specific proxy for MVS (pMVS) that corresponds to the orientation of the individual inner-ear anatomy within the static magnetic field direction (also called “z-direction” in MR imaging). We found that pMVS explained a considerable fraction of the total variance in RS-fMRI fluctuations (for instance, from 11% in the right cerebellum up to 36% in the cerebellar vermis). In addition to pMVS, we examined the angle of Reid’s plane, as determined from anatomical imaging as an alternative and found that this angle (with the same sinus transformation as for pMVS) explained considerably less variance, e.g., from 2 to 16%. In our opinion, an excess variability due to MVS should generally be addressed in fMRI research analogous to nuisance regression for movement, pulsation, and respiration effects. We suggest using the pMVS parameter to deal with modulations of RS-fMRI fluctuations due to MVS. MVS-induced variance can easily be accounted by using high-resolution anatomical imaging of the inner ear and including the proposed pMVS parameter in fMRI group-level analysis.

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Beyond binary parcellation of the vestibular cortex – A dataset

Cited by 5 publications

References 9 publications

Thresholds for vestibular and cutaneous perception and oculomotor response induced by galvanic vestibular stimulation

Thresholds for vestibular and cutaneous perception and oculomotor response induced by galvanic vestibular stimulation

Effect of galvanic vestibular stimulation applied at the onset of stance on muscular activity and gait cycle duration in healthy individuals

Modulatory effects of magnetic vestibular stimulation on resting-state networks can be explained by subject-specific orientation of inner-ear anatomy in the MR static magnetic field

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