Beyond Data Markets: Opportunities and Challenges for Distributed Ledger Technology in Genomics

Thiebes, Scott; Kannengießer, Niclas; Schmidt-Kraepelin, Manuel; Sunyaev, Ali

doi:10.24251/hicss.2020.400

Cited by 14 publications

(18 citation statements)

References 21 publications

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“…In this context, DLT has emerged as a path to application development that enables interoperability between systems by providing secure and immutable information storage and exchange [13,53]. Examples of extant use cases are defined for the following areas of healthcare: pharma, biotechnology, medicine, insurance, genomics [2,68].…”

Section: Healthcare Sectormentioning

confidence: 99%

Distributed ledger technology: State-of-the-art and current challenges

Gorbunova

Mašek

Komarov

et al. 2022

ComSIS

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Distributed Ledger Technology (DLT) is making the first steps toward becoming a solution for the growing number of various decentralized systems worldwide. Unlike pure Blockchain, DLT finds many uses across different industries, including eHealth, finance, supply chain monitoring, and the Internet of Things (IoT). One of the vital DLT features is the ability to provide an immutable and commonly verifiable ledger for larger-scale and highly complex systems. Today?s centralized systems can no longer guarantee the required level of availability and reliability due to the growing number of the involved nodes, complicated heterogeneous architectures, and task load, while the publicly available distributed systems are still in their infancy. This paper aims to provide an exhaustive topical review of the state-of-theart of Distributed Ledger Technology applicability in various sectors. It outlines the importance of the practical integration of technology-related challenges, as well as potential solutions.

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Section: Healthcare Sectormentioning

confidence: 99%

Distributed ledger technology: State-of-the-art and current challenges

Gorbunova

Mašek

Komarov

et al. 2022

ComSIS

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“…Several studies explore the use of blockchain for registering and distributing DNA data. For instance, [Ozercan et al 2018] and [Thiebes et al 2020] discuss the potential that blockchain holds for genomics, whereas companies like Nebula Genomics [Grishin et al 2018] and Encrypgen [Encrypgen 2021] use the technology in their business model. However, these companies typically act as gatekeepers, centralizing the system and removing many of the advantages of decentralization (e.g., scalability and availability).…”

Section: Related Workmentioning

confidence: 99%

Amazon Biobank - A community-based genetic database

Kimura

Andrade²,

Carvalho

et al. 2021

Anais Estendidos Do XXI Simpósio Brasileiro De Segurança Da Informação E De Sistemas Computacionais (SBSeg Estendido 2021)

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In regions like the Amazon Rainforest, there is much unexplored biodiversity data that could potentially be used to promote innovative biotechnology developments. Building a biobank with such genetic data is, however, a challenge. One reason is that existing repositories (e.g., NCBI) lack clear incentives for collaboration. Aiming to tackle this issue, and promote a biodiversity-based economy in the Amazon region, in this work we present a prototype for the Amazon Biobank, a community-based genetic database. Leveraging blockchain, smart contracts, and peer-to-peer technologies, we build a collaborative and highly scalable repository. It also enables monetary incentives for users who insert, store, process, validate and share DNA data.

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“…[98] Potential of blockchain in genomics and a use-case proposal. [110,124,125] Potential of blockchain in genomics.…”

Section: Table 1 Reviews On the Use Of Blockchain In Genomicsmentioning

confidence: 99%

“…For instance, [58] provided an overview of the current trends in using blockchain in healthcare and showed the properties of blockchain that are most commonly used, and [2] classified each work in applying blockchain in healthcare based on the use-case. Blockchain has also been proposed as a candidate approach to address many of the challenges in handling genomic data [98,110,124].…”

Section: Purpose and Objectivesmentioning

confidence: 99%

Blockchain for Genomics: A Systematic Literature Review

Alghazwi,

Turkmen,

van der Velde

et al. 2021

Preprint

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Human genomic data carry unique information about an individual and offer unprecedented opportunities for healthcare. The clinical interpretations derived from large genomic datasets can greatly improve healthcare and pave the way for personalized medicine.Sharing genomic datasets, however, pose major challenges, as genomic data is different from traditional medical data, indirectly revealing information about descendants and relatives of the data owner and carrying valid information even after the owner passes away. Therefore, stringent data ownership and control measures are required when dealing with genomic data. In order to provide secure and accountable infrastructure, blockchain technologies offer a promising alternative to traditional distributed systems. Indeed, the research on blockchain-based infrastructures tailored to genomics is on the rise. However, there is a lack of a comprehensive literature review that summarizes the current state-of-the-art methods in the applications of blockchain in genomics. In this paper, we systematically look at the existing work both commercial and academic, and discuss the major opportunities and challenges. Our study is driven by five research questions that we aim to answer in our review. We also present our projections of future research directions which we hope the researchers interested in the area can benefit from.

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Beyond Data Markets: Opportunities and Challenges for Distributed Ledger Technology in Genomics

Cited by 14 publications

References 21 publications

Distributed ledger technology: State-of-the-art and current challenges

Distributed ledger technology: State-of-the-art and current challenges

Amazon Biobank - A community-based genetic database

Blockchain for Genomics: A Systematic Literature Review

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