Beyond Extracellular Vesicles: Hybrid Membrane Nanovesicles as Emerging Advanced Tools for Biomedical Applications

Sun, Meng; Yang, Jiani; Fan, Yueyun; Zhang, Yinfeng; Sun, Jian; Hu, Min; Sun, Ke; Zhang, Jinfeng

doi:10.1002/advs.202303617

Cited by 25 publications

(6 citation statements)

References 142 publications

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“…Therefore, engineering of multifunctional hybrid nanovesicles mimicking natural extracellular vesicles but with favorable adaptability and flexibility has become a key challenge in expanding their application. [130][131][132] Such nanovesicles are nano-sized vesicles composed of lipid bilayers and/or other materials. They have garnered significant interest due to their unique properties and ability to encapsulate and deliver therapeutic agents, biomolecules, and imaging agents, thus offering opportunities for targeted drug delivery, diagnostics, and therapeutic interventions.…”

Section: Methodsmentioning

confidence: 99%

Nanoscale materials at work: Mapping emerging applications in energy, medicine, and beyond

Hughes,

Ganesan,

Tenchov

et al. 2024

Preprint

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Since their inception in the early 1960s, the use of nanoscale materials has progressed in leaps and bounds, and their role in diverse fields ranging from human health to energy is undeniable. In this report, we utilize the CAS Content Collection, a vast repository of scientific information extracted from journal and patent publications, to identify emerging topics in this field. This involves understanding trends, such as the growth of certain topics over time, as well as establishing relationships between emerging topics. We achieved this by using a host of strategies including a quantitative natural language processing (NLP) approach to identify 279 emerging topics and sub-topics across three major categories – materials, applications, and properties – by surveying roughly 3 million publications in the nanoscience landscape. This wealth of information has been condensed into several conceptual mind maps and other graphs that provide metrics related to the growth of identified emerging concepts, group them into hierarchical classes, and explore the connections between them. We delved deeper into four major emerging applications of nanoscale materials – drug delivery, sensors, energy, and catalysis – to provide a more comprehensive and detailed picture of the use of nanotechnology in these fields. In addition, we leveraged the CAS registry, consisting of over 250 million substances, to determine and discover substances across varied classes (such as polymers, elements, organic/inorganic molecules) and how they are utilized in the 4 major applications. Our extensive analysis taking advantage of an NLP-based approach along with robust CAS indexing provides valuable insights in the field that we hope can help to inform and drive future research efforts.

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Section: Methodsmentioning

confidence: 99%

Nanoscale materials at work: Mapping emerging applications in energy, medicine, and beyond

Hughes,

Ganesan,

Tenchov

et al. 2024

Preprint

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“…In biomedical research, there is a subsection of scientists currently developing innovative, multifunctional fusion nanovesicles (FVs) (Sun et al 2023). These are specifically designed to target lesions and are a promising avenue for treating various autoimmune skin diseases.…”

Section: Prevent Skin Agingmentioning

confidence: 99%

Plant‐derived nanovesicles offer a promising avenue for anti‐aging interventions

Meng,

Sun,

et al. 2024

Physiologia Plantarum

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Over the past few years, the study of plant‐derived nanovesicles (PDNVs) has emerged as a hot topic of discussion and research in the scientific community. This remarkable interest stems from their potential role in facilitating intercellular communication and their unique ability to deliver biologically active components, including proteins, lipids, and miRNAs, to recipient cells. This fascinating ability to act as a molecular courier has opened up an entirely new dimension in our understanding of plant biology. The field of research focusing on the potential applications of PDNVs is still in its nascent stages. However, it has already started gaining traction due to the growing interest in its possible use in various branches of biotechnology and medicine. Their unique properties and versatile applications offer promising future research and development prospects in these fields. Despite the significant progress in our understanding, many unanswered questions and mysteries surround the mechanisms by which PDNVs function and their potential applications. There is a dire need for further extensive research to elucidate these mechanisms and explore the full potential of these fascinating vesicles. As the technology at our disposal advances and our understanding of PDNVs deepens, it is beyond doubt that PDNVs will continue to be a subject of intense research in anti‐aging therapeutics. This comprehensive review is designed to delve into the fascinating and multifaceted world of PDNV‐based research, particularly focusing on how these nanovesicles can be applied to anti‐aging therapeutics.

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“…Furthermore, multifunctional hybrid membrane nanovesicles represent an advancement over exosomes, enabling synchronous execution of overlaid functions from diverse producer cells. These nanovesicles offer promise for developing a highly customizable therapeutic platform for DFU with multiple targeting and diverse therapeutic functions [ 255 ].…”

Section: Reviewmentioning

confidence: 99%

Engineered exosomes as a prospective therapy for diabetic foot ulcers

Guo,

Xiao,

Xing

et al. 2024

Burns &Amp; Trauma

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Diabetic foot ulcer (DFU), characterized by high recurrence rate, amputations and mortality, poses a significant challenge in diabetes management. The complex pathology involves dysregulated glucose homeostasis leading to systemic and local microenvironmental complications, including peripheral neuropathy, micro- and macro-angiopathy, recurrent infection, persistent inflammation and dysregulated re-epithelialization. Novel approaches to accelerate DFU healing are actively pursued, with a focus on utilizing exosomes. Exosomes are natural nanovesicles mediating cellular communication and containing diverse functional molecular cargos, including DNA, mRNA, microRNA (miRNA), lncRNA, proteins, lipids and metabolites. While some exosomes show promise in modulating cellular function and promoting ulcer healing, their efficacy is limited by low yield, impurities, low loading content and inadequate targeting. Engineering exosomes to enhance their curative activity represents a potentially more efficient approach for DFUs. This could facilitate focused repair and regeneration of nerves, blood vessels and soft tissue after ulcer development. This review provides an overview of DFU pathogenesis, strategies for exosome engineering and the targeted therapeutic application of engineered exosomes in addressing critical pathological changes associated with DFUs.

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Beyond Extracellular Vesicles: Hybrid Membrane Nanovesicles as Emerging Advanced Tools for Biomedical Applications

Cited by 25 publications

References 142 publications

Nanoscale materials at work: Mapping emerging applications in energy, medicine, and beyond

Nanoscale materials at work: Mapping emerging applications in energy, medicine, and beyond

Plant‐derived nanovesicles offer a promising avenue for anti‐aging interventions

Engineered exosomes as a prospective therapy for diabetic foot ulcers

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