Beyond free radical scavenging: Beneficial effects of edaravone (Radicut) in various diseases (Review)

Abstract

Abstract. Free radicals play an important role in the

Morphological and Morphometric Study of Edaravone in Gentamicin-Induced Nephrotoxicity in Sprague Dawley Rats

“…The natural antioxidants such as β-carotene, 28 a terpenoid constituent of the crude extract can ameliorate the nephrotoxicity by its free radical scavenging activity. Edaravone, is a synthetic-free radical scavenger 6 besides its potent free radical scavenging effects, edaravone possesses anti-apoptotic and anti-necrotic effects in animal models of various diseases. 7 Edaravone possess nephroprotective property by promoting antioxidant enzyme system, thereby attenuating ROS generation and lipid peroxidation as similar to Wongmekiat et al, 2008.…”

“…5 Edaravone is chemically known as 3-methyl-1-phenyl-2-pyrazolin-5-one, it is a synthetic-free radical scavenger. 6 It was the first neuroprotective drug to be introduced in worldwide by Japan in treating patients with cerebral infarction. 6 Moreover it's has a potent free radical scavenging effects, edaravone possesses anti-necrotic and anti-apoptotic effects in varies diseases of animal models.…”

“…6 It was the first neuroprotective drug to be introduced in worldwide by Japan in treating patients with cerebral infarction. 6 Moreover it's has a potent free radical scavenging effects, edaravone possesses anti-necrotic and anti-apoptotic effects in varies diseases of animal models. 7 Therefore, it might be necessary to investigate its therapeutic potential in nephrotoxicity in associated with oxidative stress and cell death.…”

Edaravone (Radicut), a free radical scavenger, is a potentially useful addition to thrombolytic therapy in patients with acute ischemic stroke

“…Taken together, these findings indicate that edaravone may be useful for the treatment of patients with AIS, due to its being involved in inhibiting the deleterious molecular events associated with brain injury. Beyond AIS, edaravone has also been reported to have diverse protective effects against the ischemic injury of various other organs in several animal disease models (30)(31)(32)(33)(34).…”

The effects of edaravone in ketamine-induced model of mania in rats

“…It has been shown to exhibit neuroprotective effects against oxidative stress in patients with cerebral infarction and acute ischemic stroke (Yoshida et al 2006). In vivo and in vitro studies have found that edaravone has a neuroprotective effect in animal models of amyotrophiclateral sclerosis and Parkinson's disease (Kikuchi et al 2012). We hypothesized that edaravone, a substance with known neuroprotective effects, might have protective effects in mania in an animal model of BD.…”