Beyond Glucose: The Dual Assault of Oxidative and ER Stress in Diabetic Disorders

Roohi, Tamsheel Fatima; Faizan, Syed; Parray, Zahoor Ahmad; Baig, MD. Awaise Iqbal; Mehdi, Seema; Kinattingal, Nabeel; Krishna, K. L.

doi:10.1007/s40292-023-00611-3

Cited by 7 publications

(1 citation statement)

References 133 publications

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“…Beta-cells are particularly susceptible to autoimmune cytotoxic damage due to the relatively high endoplasmic reticular and oxidative stress that exists under normal physiology as a consequence of the high metabolic activity required for continuous synthesis of large quantities of insulin and rapid exocytosis into the islet vascular bed [216]. This results in beta-cells being sensitive to even small changes in the islet inflammatory environment and the presence of cytotoxic CD8 + and CD4 + T-cells [217].…”

Section: Islet Paracrine Disruption In T1dmentioning

confidence: 99%

The Importance of Intra-Islet Communication in the Function and Plasticity of the Islets of Langerhans during Health and Diabetes

Hill,

Hill

2024

IJMS

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Islets of Langerhans are anatomically dispersed within the pancreas and exhibit regulatory coordination between islets in response to nutritional and inflammatory stimuli. However, within individual islets, there is also multi-faceted coordination of function between individual beta-cells, and between beta-cells and other endocrine and vascular cell types. This is mediated partly through circulatory feedback of the major secreted hormones, insulin and glucagon, but also by autocrine and paracrine actions within the islet by a range of other secreted products, including somatostatin, urocortin 3, serotonin, glucagon-like peptide-1, acetylcholine, and ghrelin. Their availability can be modulated within the islet by pericyte-mediated regulation of microvascular blood flow. Within the islet, both endocrine progenitor cells and the ability of endocrine cells to trans-differentiate between phenotypes can alter endocrine cell mass to adapt to changed metabolic circumstances, regulated by the within-islet trophic environment. Optimal islet function is precariously balanced due to the high metabolic rate required by beta-cells to synthesize and secrete insulin, and they are susceptible to oxidative and endoplasmic reticular stress in the face of high metabolic demand. Resulting changes in paracrine dynamics within the islets can contribute to the emergence of Types 1, 2 and gestational diabetes.

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Section: Islet Paracrine Disruption In T1dmentioning

confidence: 99%

The Importance of Intra-Islet Communication in the Function and Plasticity of the Islets of Langerhans during Health and Diabetes

Hill,

Hill

2024

IJMS

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Targeting Autophagy: A Promising Therapeutic Strategy for Diabetes Mellitus and Diabetic Nephropathy

Li,

Xu,

et al. 2024

Diabetes Ther

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Diabetes mellitus (DM) significantly impairs patients’ quality of life, primarily because of its complications, which are the leading cause of mortality among individuals with the disease. Autophagy has emerged as a key process closely associated with DM, including its complications such as diabetic nephropathy (DN). DN is a major complication of DM, contributing significantly to chronic kidney disease and renal failure. The intricate connection between autophagy and DM, including DN, highlights the potential for new therapeutic targets. This review examines the interplay between autophagy and these conditions, aiming to uncover novel approaches to treatment and enhance our understanding of their underlying pathophysiology. It also explores the role of autophagy in maintaining renal homeostasis and its involvement in the development and progression of DM and DN. Furthermore, the review discusses natural compounds that may alleviate these conditions by modulating autophagy.

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Reactive oxygen species-responsive prodrugs

Clément,

Winum

2025

Advances in Prodrugs

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Beyond Glucose: The Dual Assault of Oxidative and ER Stress in Diabetic Disorders

Cited by 7 publications

References 133 publications

The Importance of Intra-Islet Communication in the Function and Plasticity of the Islets of Langerhans during Health and Diabetes

The Importance of Intra-Islet Communication in the Function and Plasticity of the Islets of Langerhans during Health and Diabetes

Targeting Autophagy: A Promising Therapeutic Strategy for Diabetes Mellitus and Diabetic Nephropathy

Reactive oxygen species-responsive prodrugs

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