Beyond intima-media-thickness: Analysis of the carotid intima-media-roughness in a paediatric population

Pozza, Robert Dalla; Pirzer, Raphael; Beyerlein, Andreas; Weberruß, Heidi; Oberhoffer, Renate; Schmidt‐Trucksäss, Arno; Netz, Heinrich; Haas, Nikolaus A.

doi:10.1016/j.atherosclerosis.2016.06.014

Cited by 15 publications

(15 citation statements)

References 43 publications

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“… Summary of the review of published data on cIMT in the pediatric population for studies reporting mean cIMT data for (A) 6–18-year age range ( 5 , 15 – 19 , 26 , 29 , 46 – 58 ), (B) under ten years ( 5 , 16 – 19 , 47 , 48 , 53 , 55 , 59 – 61 ), (C) 10–14 years ( 16 – 19 , 47 , 48 , 53 , 62 – 64 ), (D) 14–18-year age range ( 5 , 15 , 17 – 19 , 24 , 47 , 48 , 53 , 55 , 65 – 70 ). …”

Section: Resultsmentioning

confidence: 99%

Carotid Intima-Media Thickness in Healthy Children and Adolescents: Normative Data and Systematic Literature Review

Torkar

Plesnik

Grošelj

et al. 2020

Front. Cardiovasc. Med.

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Objectives: Early identification of children at risk of atherosclerosis is of paramount importance for implementing primary preventive measures addressing vascular health. Carotid intima-media thickness (cIMT) is a non-invasive biomarker of atherosclerosis. Semiautomatic radiofrequency-based software-guided technique quality intima-media thickness (RF-QIMT) was used to determine cIMT normative values in a healthy cohort of Caucasian children aged 6 to 18 years.Study design: In a cross-sectional study, data on age, chronic illness, medication use, and pubertal status was acquired by a questioner. Anthropometric and blood pressure measurements were performed by standardized methods and trained medical personnel. cIMT of the right common carotid artery far wall (1 centimeter proximal to bifurcation) was determined using a multifrequency (3–13 MHz) electronic linear array transducer SL1543, a portable ultrasound device (MyLab Gamma Esaote, Genoa, Italy), and RF-QIMT software. A systematic review of the published normal cIMT in children was done using PRISMA methodology, and identified normative values were compared to those obtained in the presented study.Results: 1137 non-obese normotensive children (males: n = 512; mean age 12.04 ± 3.52 years, females: n = 625, mean age 12.98 ± 3.83 years) were included. Gender-, age-, and height-specific mean cIMT percentile tables, percentile charts, and LMS tables for the RF-QIMT method were provided. They were comparable to the previously published data on mean cIMT gained by other validated ultrasound imaging techniques. cIMT increased with age, height, hip circumference, and BMI and was higher in males.Conclusions: Gender-, age-, and height-specific normative cIMT values, using the semiautomatic software-guided RF-QIMT technique, in children aged 6 to 18 years were developed and validated in respect to the previously published pediatric normative cIMT data. It is suggested that the investigated method could be used for the estimation of atherosclerotic risk in children, especially in epidemiological studies.

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Section: Resultsmentioning

confidence: 99%

Carotid Intima-Media Thickness in Healthy Children and Adolescents: Normative Data and Systematic Literature Review

Torkar

Plesnik

Grošelj

et al. 2020

Front. Cardiovasc. Med.

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“…Atherosclerosis has been shown to occur as early as nine years of age, and the cross-sectional area of the common carotid artery wall and the mean intima-media thickness of the internal carotid artery have been shown to be higher in obese children than in lean children (14). Studies have shown that a high CIMT can return to normal after the correction and treatment of cardiovascular risk factors (15,16).…”

Section: Discussionmentioning

confidence: 99%

“…In a previous adult study, the PG level at 60 min and PG∆60 were related with the CIMT (4). Dalla Pozza et al (16) reported that the CIMT was correlated with BMI, abdominal circumference, the waist-tohip ratio, and maximum oxygen uptake in healthy children. Nathan et al (19).…”

Section: Discussionmentioning

confidence: 99%

Association Between the Common Carotid Artery Intima-Media Thickness and Glucose Metabolism in Obese Children

Lee

Kwon

et al. 2019

Iran J Pediatr

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Objectives: To determine the relationship between glucose metabolism and atherosclerosis assessed according to the common carotid artery intima-media thickness (CIMT) in non-diabetic obese children. Methods: We performed anthropometric measurements and laboratory tests, including the oral glucose tolerance test (OGTT). The CIMTs on both sides were measured in obesity (body mass index [BMI] ≥ 95 percentile) children by one researcher. Results: There were 44 boys and 22 girls, and the mean age was 10.73 ± 2.48 years (range, 8-14 years). The mean CIMT on both sides, age, BMI, blood pressure, lipid profile, OGTT results, and HbA1c level were not significantly different between the boys and girls. Simple correlation analyses showed that the fasting plasma glucose (PG) level (γ = 0.266, P = 0.034), PG at 90 min (γ = 0.318, P = 0.014), PG at 120 min (γ = 0.336, P = 0.009), HbA1c level (γ = 0.306, P = 0.015), PG increase at 90 min (PG∆90) (γ = 0.310, P = 0.017), and PG∆120 (γ = 0.338, P = 0.009) were significantly correlated with the left CIMT. In multiple regression analysis, the HbA1c level, PG∆90, and PG∆120 were significantly associated with the left CIMT (P < 0.01). Conclusions: Ultrasound-measured CIMT, especially the left CIMT, is a reasonable glucose metabolic indicator of atherosclerotic vascular complications in obese children.

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“…No Brasil, estudos mostram uma frequência de 50% de placas ateroscleróticas em mulheres com lúpus eritematoso sistêmico com média de idade de 34 anos (Souza et al, 2005). (Doyon et al, 2013;Dalla Pozza et al, 2016), e para os adolescentes entre 18 e 21 anos (Denarie et al, 2000;Jourdan et al, 2005) e consideramos aterosclerose subclínica um espessamento médio-intimal carotídeo superior ao percentil 90 (Magnussen et al, 2009). O lúpus eritematoso sistêmico está associado ao desenvolvimento de aterosclerose precoce e os pacientes apresentam risco até seis vezes maior de desenvolver lesões ateroscleróticas quando comparados com a população geral (Bjornadal et al, 2004;Bartels et al, 2014).…”

Section: Discussionunclassified

“…resultados. Os valores de normalidade utilizados foram baseados em estudo populacional para crianças, menores de 18 anos (figura 3) (Doyon et al, 2013;Dalla Pozza et al, 2016), e para os adolescentes entre 18 e 21 anos (tabela 2) (Denarie et al, 2000;Jourdan et al, 2005), um espessamento médio-intimal carotídeo superior ao percentil 90 foi considerado como alto e sugestivo de aterosclerose subclínica (Magnussen et al, 2009). Denarie, N., et al, Atherosclerosis, 2000) 6.…”

Section: Figuraunclassified

Avaliação de aterosclerose subclínica em pacientes com Lúpus Eritematoso Sistêmico Juvenil

Medeiros¹

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Palavras chave: lúpus eritematoso sistêmico juvenil. risco cardiovascular. aterosclerose subclínica. espessura médio-intimal carotídea (EMIc). dislipidemia fatores de risco cardiovascular não tradicionais. dieta ABSTRACT MEDEIROS, Priscila Beatriz de Souza. Assessment of Subclinical Atherosclerosis associated with Pediatric Systemic Lupus Erythematosus.2019.108pages. Dissertation (Master´s degree in the Child and

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Beyond intima-media-thickness: Analysis of the carotid intima-media-roughness in a paediatric population

Cited by 15 publications

References 43 publications

Carotid Intima-Media Thickness in Healthy Children and Adolescents: Normative Data and Systematic Literature Review

Carotid Intima-Media Thickness in Healthy Children and Adolescents: Normative Data and Systematic Literature Review

Association Between the Common Carotid Artery Intima-Media Thickness and Glucose Metabolism in Obese Children

Avaliação de aterosclerose subclínica em pacientes com Lúpus Eritematoso Sistêmico Juvenil

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