2017
DOI: 10.1111/evo.13343
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Beyond mean allelic effects: A locus at the major color geneMC1Rassociates also with differing levels of phenotypic and genetic (co)variance for coloration in barn owls

Abstract: The mean phenotypic effects of a discovered variant help to predict major aspects of the evolution and inheritance of a phenotype. However, differences in the phenotypic variance associated to distinct genotypes are often overlooked despite being suggestive of processes that largely influence phenotypic evolution, such as interactions between the genotypes with the environment or the genetic background. We present empirical evidence for a mutation at the melanocortin-1-receptor gene, a major vertebrate colorat… Show more

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Cited by 8 publications
(19 citation statements)
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References 85 publications
(178 reference statements)
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“…Most notably, pigmentation and its pattern formation have been major research interests in recent years (Eizirik & Trindade, 2021). For example, melanocortin receptor 1 was found to control normal pigmentation, particularly in relation to the black coat that evolved independently in mammals (Rochus et al, 2018; San‐Jose et al, 2017). The coat phenotypic variation of O. thibetana includes clear colour and thickness variations among different lineages.…”
Section: Discussionmentioning
confidence: 99%
“…Most notably, pigmentation and its pattern formation have been major research interests in recent years (Eizirik & Trindade, 2021). For example, melanocortin receptor 1 was found to control normal pigmentation, particularly in relation to the black coat that evolved independently in mammals (Rochus et al, 2018; San‐Jose et al, 2017). The coat phenotypic variation of O. thibetana includes clear colour and thickness variations among different lineages.…”
Section: Discussionmentioning
confidence: 99%
“…However, most previous association studies in this species using coat colour as clustering parameter were performed in phenotypes associated with health disorders (Reissmann & Ludwig, 2013). This could be explained by the existence of a highly pleiotropic gene network involving the melanocortin system and colour regulation (San-Jose, Ducret, Ducrest, Simon, & Roulin, 2017). This system is also involved in energy metabolism in domestic animals (Andersson, 2003) and animal growth (MC4R variant in pig) (Van Den Broeke et al, 2015).…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, the results of KEGG analysis revealed many potential genes from the melanogenesis pathway. At present, many candidate genes in the melanogenesis pathway have already been shown to be related to coat color, including melanocortin 1 receptor (MC1R) (e.g., San-Jose et al, 2017), melanocyte-stimulating hormone (MSH) (e.g., Jo et al, 2017), and microphthalmia-associated transcription factor (MITF) (e.g., Irizarry and Bryden, 2016;Wang et al, 2017;Xia et al, 2017). Here, a series of DEMs whose targets are involved in the melanogenesis pathway were identified (Table 1), including Frizzled-7 (FZD7) and Frizzled-6 (FZD6), which are found in a variety of cancer cells and related to signal transduction (Cao et al, 2017;Liu et al, 2017;Yang et al, 2011;Corda et al, 2017).…”
Section: Resultsmentioning
confidence: 99%