Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Clayton, Ellen Wright

doi:10.1001/jama.2015.1346

Cited by 272 publications

(262 citation statements)

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“…Two additional clinical features in ME/CFS could be explained by the leptin levels in our patients. ME/CFS occurs more frequently in women than in men (2). Leptin levels are higher in females than males, even when corrected for confounding variables such as body mass index Table 4.…”

Section: Discussionmentioning

confidence: 99%

“…cytokines | chronic fatigue syndrome | immune monitoring | severity | myalgic encephalomyelitis M yalgic encephalomyelitis or chronic fatigue syndrome (ME/ CFS) is a complex and debilitating disease of unknown etiology affecting more than one million Americans and millions of individuals worldwide (1,2). ME/CFS is characterized by persistent or relapsing unexplained fatigue of at least 6-mo duration that is not alleviated by rest and results in a substantial reduction in previous levels of occupational, educational, social, and personal activities (2)(3)(4)(5).…”

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confidence: 99%

“…ME/CFS is characterized by persistent or relapsing unexplained fatigue of at least 6-mo duration that is not alleviated by rest and results in a substantial reduction in previous levels of occupational, educational, social, and personal activities (2)(3)(4)(5). In ME/CFS patients, fatigue is just one of multiple incapacitating symptoms that include cognitive impairment, postexertional malaise, unrefreshing sleep, headaches, myalgias, arthralgias, sore throats, lymphadenopathy, hypersensitivity to noise, light, or certain food items, and autonomic disturbances (4).…”

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confidence: 99%

“…"ME/CFS" has been the term generally preferred by researchers, but the terms "myalgic encephalomyelitis" (ME) or "chronic fatigue and immune dysfunction syndrome" (CFIDS) are favored by clinicians and patients, given the wide range of complaints and the heterogeneity of the illness (1,4,6,7). In a recent report, the Institute of Medicine proposed a new definition for ME/CFS and a new name: "systemic exertion intolerance disease" (SEID) (2).…”

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confidence: 99%

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Cytokine signature associated with disease severity in chronic fatigue syndrome patients

Montoya

Holmes

Anderson

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

312

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Although some signs of inflammation have been reported previously in patients with myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS), the data are limited and contradictory. High-throughput methods now allow us to interrogate the human immune system for multiple markers of inflammation at a scale that was not previously possible. To determine whether a signature of serum cytokines could be associated with ME/CFS and correlated with disease severity and fatigue duration, cytokines of 192 ME/CFS patients and 392 healthy controls were measured using a 51-multiplex array on a Luminex system. Each cytokine’s preprocessed data were regressed on ME/CFS severity plus covariates for age, sex, race, and an assay property of newly discovered importance: nonspecific binding. On average, TGF-β was elevated (P = 0.0052) and resistin was lower (P = 0.0052) in patients compared with controls. Seventeen cytokines had a statistically significant upward linear trend that correlated with ME/CFS severity: CCL11 (Eotaxin-1), CXCL1 (GROα), CXCL10 (IP-10), IFN-γ, IL-4, IL-5, IL-7, IL-12p70, IL-13, IL-17F, leptin, G-CSF, GM-CSF, LIF, NGF, SCF, and TGF-α. Of the 17 cytokines that correlated with severity, 13 are proinflammatory, likely contributing to many of the symptoms experienced by patients and establishing a strong immune system component of the disease. Only CXCL9 (MIG) inversely correlated with fatigue duration.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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Cytokine signature associated with disease severity in chronic fatigue syndrome patients

Montoya

Holmes

Anderson

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

312

265

View full text Add to dashboard Cite

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“…CFS has been defined already in new diagnosis criteria by the Institute of Medicine IOM [16] as follows: (1) A substantial reduction or impairment in the ability to engage in pre-illness levels of occupational, educational, social or personal activities that persists for more than 6 months and is accompanied by fatigue, which is often profound, is of new or definite onset (not lifelong), is not the result of ongoing excessive exertion and is not substantially alleviated by rest; (2) postexertional malaise (often described by patients as a ''crash'' or ''collapse'' after even minor physical or mental exertion); (3) unrefreshing sleep; and (4) cognitive impairment and/or orthostatic intolerance.…”

mentioning

confidence: 99%