Beyond Physical Exercise: The Role of Nutrition, Gut Microbiota and Nutraceutical Supplementation in Reducing Age-Related Sarcopenia

Abstract

Sarcopenia, a commonly prevalent geriatric condition mainly characterized by progressive loss of the skeletal muscle mass that result in noticeable reduced muscle strength and quality. Most of the geriatric population of above 60 years of age are overweight leading to the accumulation of fat in the muscles resulting in abated muscle function. The increased loss of muscle mass is associated with high rates of disability, poor motility, frailty and mortality. The excessive degeneration of muscles is now also being observed in middle aged people. Therefore, geriatrics has recently started shifting towards the identification of early stages of the disability in order to expand the life span of the patient and reduce physical dependence. Recent findings have indicated that patients with increased physical activity are also affected by sarcopenia, therefore indicating the role of nutritional supplements to enhance muscle health which in turn helps to counteract sarcopenia. Various interventions with physical trainings haven’t provided substantial improvements of this disorder thereby highlighting the crucial role of nutritional supplementation in enhancing muscle mass and strength. Nutritional supplementation has not only shown to enhance the positive effects of physical interventions but also have a profound impact on the gut microbiome that has come forward as a key regulator of muscle mass and function. This brief review throws light upon the efficiency of nutrients and nutraceutical supplementation by highlighting their ancillary effects in physical interventions as well as improving the gut microbiome status in sarcopenic adults thereby giving rise to a multimodal intervention for the treatment of sarcopenia.

Research hotspots and trends of exercise for sarcopenia: A bibliometric analysis

“…In addition, the results of several studies confirm that exercise combined with nutritional supplementation is the best choice for the rehabilitation of sarcopenia. Supplementation with protein, amino acids, vitamin D and other nutrients along with exercise intervention can promote muscle protein synthesis, muscle cell proliferation and differentiation, significantly delaying muscle aging (19,(58)(59)(60)(61).…”