2022
DOI: 10.1042/bcj20210280
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Beyond protein modification: the rise of non-canonical ADP-ribosylation

Abstract: ADP-ribosylation has primarily been known as post-translational modification of proteins. As signalling strategy conserved in all domains of life, it modulates substrate activity, localisation, stability or interactions, thereby regulating a variety of cellular processes and microbial pathogenicity. Yet over the last years, there is increasing evidence of non-canonical forms of ADP-ribosylation that are catalysed by certain members of the ADP-ribosyltransferase family and go beyond traditional protein ADP-ribo… Show more

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Cited by 25 publications
(19 citation statements)
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References 137 publications
(204 reference statements)
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“…ADP-ribosylation is an evolutionarily and functionally conserved chemical modification mostly studied in the context of protein post-translational modification. For the past decade, though, there has been an increasing amount of evidence placing its origin in the modification of nucleic acids [5] , [6] , [10] , [28] , [31] , [33] , [34] , [35] , [41] , [42] , [57] .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…ADP-ribosylation is an evolutionarily and functionally conserved chemical modification mostly studied in the context of protein post-translational modification. For the past decade, though, there has been an increasing amount of evidence placing its origin in the modification of nucleic acids [5] , [6] , [10] , [28] , [31] , [33] , [34] , [35] , [41] , [42] , [57] .…”
Section: Discussionmentioning
confidence: 99%
“…ADP-ribosylation is an evolutionarily conserved, reversible chemical modification utilized by all domains of life and viruses [1] , [2] , [3] , [4] . (ADP-ribosyl)transferases (ARTs) covalently attach adenosine diphosphate ribose (ADPr) from the metabolic cofactor NAD + to different substrates, such as proteins, nucleic acids, and small molecules (including antibiotics), [5] , [6] , [7] , [8] , [9] , [10] . The modification is reversed by two canonical but evolutionary distinct families - macrodomains and (ADP-ribosyl)hydrolases [5] , [11] .…”
Section: Introductionmentioning
confidence: 99%
“…Of particular interest from this perspective is that recent discoveries have established nucleic acids, such as genomic DNA and RNAs, as novel ADP-ribosylation targets [ 48 , 49 , 50 ], which, although involved in crucial physiological processes, are not yet fully understood in either mammals or prokaryotes [ 47 , 48 , 50 , 108 ]. To date, the ADP-ribosylation of DNA has only been characterised in a few bacterial systems including pierisin-like members and the DarT/DarG system.…”
Section: Adp-ribosylation In Bacteriamentioning
confidence: 99%
“…Calcium channels mediate sAR in bovine sperm including the sperm-specific cation channel CatSper [ 48 ]. NMDA-type glutamate receptor mediates sAR in newt sperm [ 49 ]. The knockout of mice to β-Defensin [ 49 ], of the lipocalin family [ 49 ], or to the aldehyde dehydrogenase ALDH4A1, a key enzyme in mitochondrial prolin metabolism [ 50 ], shows an increase in sperm sAR.…”
Section: Roles Of Fer In Modulating Sperm Functionsmentioning
confidence: 99%