Beyond the centrosome: The mystery of microtubule organising centres across mammalian preimplantation embryos

Martínez, Sebastián Palacios; Greaney, Jessica; Zenker, Jennifer

doi:10.1016/j.ceb.2022.102114

Cited by 3 publications

(3 citation statements)

References 74 publications

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“…Consequently, centriole-independent early embryonic development (i.e., development of the embryo during the zygote and morula stages occurring without centrioles) evolved in the mouse ancestor 18 , 22 , 43 – 51 . Centriole-independent early embryonic development is mediated by an egg-derived mechanism involving maternal cytoplasmic centrosomes and post-cytokinetic microtubule bridges 47 , 52 – 55 .…”

Section: Introductionmentioning

confidence: 99%

The evolution of centriole degradation in mouse sperm

Khanal,

Jaiswal,

Chowdanayaka

et al. 2024

Nat Commun

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Centrioles are subcellular organelles found at the cilia base with an evolutionarily conserved structure and a shock absorber-like function. In sperm, centrioles are found at the flagellum base and are essential for embryo development in basal animals. Yet, sperm centrioles have evolved diverse forms, sometimes acting like a transmission system, as in cattle, and sometimes becoming dispensable, as in house mice. How the essential sperm centriole evolved to become dispensable in some organisms is unclear. Here, we test the hypothesis that this transition occurred through a cascade of evolutionary changes to the proteins, structure, and function of sperm centrioles and was possibly driven by sperm competition. We found that the final steps in this cascade are associated with a change in the primary structure of the centriolar inner scaffold protein FAM161A in rodents. This information provides the first insight into the molecular mechanisms and adaptive evolution underlying a major evolutionary transition within the internal structure of the mammalian sperm neck.

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“…Consequently, centriole-independent early embryonic development (i.e., development of the embryo during the zygote and morula stages occurring without centrioles) evolved in the mouse ancestor 18 , 22 , 43 – 51 . Centriole-independent early embryonic development is mediated by an egg-derived mechanism involving maternal cytoplasmic centrosomes and post-cytokinetic microtubule bridges 47 , 52 – 55 .…”

Section: Introductionmentioning

confidence: 99%

The evolution of centriole degradation in mouse sperm

Khanal,

Jaiswal,

Chowdanayaka

et al. 2024

Nat Commun

View full text Add to dashboard Cite

show abstract

“…Consequently, centriole-independent early embryonic development (i.e., development of the embryo during the zygote and morula stages occurring without centrioles) evolved in the mouse ancestor (Bangs et al, 2015; Calarco, 2000; Clift and Schuh, 2015; Coelho et al, 2013; Fawcett, 1975; Gueth-Hallonet et al, 1993; Manandhar et al, 1999; Schatten et al, 1985; Schatten et al, 1986; Simerly et al, 1993; Woolley and Fawcett, 1973). Centriole-independent early embryonic development is mediated by an egg-derived mechanism involving maternal cytoplasmic centrosomes and post-cytokinetic microtubule bridges (Coelho et al, 2013; Jin et al, 2012; Zenker et al, 2017) (reviewed in Fishman et al, 2021; Palacios Martinez et al, 2022). Stage 4 – The Muridae centriolar configuration : Because embryonic development became centriole-independent, spermatozoan centrioles were freed from the functional constraints imposed by their role in the embryo.…”

Section: Introductionmentioning

confidence: 99%

“…Consequently, centriole-independent early embryonic development (i.e., development of the embryo during the zygote and morula stages occurring without centrioles) evolved in the mouse ancestor (Bangs et al, 2015; Calarco, 2000; Clift and Schuh, 2015; Coelho et al, 2013; Fawcett, 1975; Gueth-Hallonet et al, 1993; Manandhar et al, 1999; Schatten et al, 1985; Schatten et al, 1986; Simerly et al, 1993; Woolley and Fawcett, 1973). Centriole-independent early embryonic development is mediated by an egg-derived mechanism involving maternal cytoplasmic centrosomes and post-cytokinetic microtubule bridges (Coelho et al, 2013; Jin et al, 2012; Zenker et al, 2017) (reviewed in Fishman et al, 2021; Palacios Martinez et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

The Evolution of Centriole Degradation in Mouse Sperm

Khanal

Puente

Chandanayaka

et al. 2023

Preprint

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Centrioles are subcellular organelles with an evolutionarily conserved structure and a shock absorber-like function. In sperm, centrioles are found at the flagellum base and are essential for embryo development in basal animals. Yet, sperm centrioles have evolved diverse forms, sometimes acting like a transmission system, as in cattle, and sometimes becoming dispensable, as in house mice. How the essential sperm centriole evolved to become dispensable in some organisms is unclear. Here, we test the hypothesis that this transition occurred through a cascade of evolutionary changes to the proteins, structure, and function of sperm centrioles and was possibly driven by sperm competition. We found that the last steps in this cascade are associated with a change in the primary structure of the centriolar luminal protein FAM161A in rodents. This information provides the first insight into the molecular mechanisms and adaptive evolution underlying a major evolutionary transition within the internal structure of the mammalian sperm neck.

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Editorial overview: Functional specialization of the cytoskeleton in diverse cell types

Marston,

Tyska

2024

Current Opinion in Cell Biology

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Beyond the centrosome: The mystery of microtubule organising centres across mammalian preimplantation embryos

Cited by 3 publications

References 74 publications

The evolution of centriole degradation in mouse sperm

The evolution of centriole degradation in mouse sperm

The Evolution of Centriole Degradation in Mouse Sperm

Editorial overview: Functional specialization of the cytoskeleton in diverse cell types

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