Beyond the Superficial: Disseminated Trichophyton rubrum Infection in a Kidney Transplant Recipient

Abstract

<jats:title>Abstract</jats:title> <jats:p>Superficial dermatophyte infections are common in the general population and are readily treated with topical antifungals. Deeper invasion is rare, and dissemination to visceral organs is extremely uncommon. We describe a 66 year old renal transplant recipient who developed disseminated Trichophyton rubrum infection while undergoing treatment for acute humoral rejection. The infection presented as a facial rash with subsequent dissemination to the lungs and chest wall. All sites of infection improved with combination administration of oral posaconazole and terbinafine. In this work, we review the available literature regarding management of disseminated Trichophyton infection and discuss therapeutic interventions for disseminated dermatophytosis in immunosuppressed hosts.</jats:p>

In vitro antidermatophytic activity of bioactive compounds from selected medicinal plants

“…Dermatophytoses are characterized by superficial invasion by fungal hyphae in the skin, hair, and nails causing subacute or chronic infections (Burstein et al 2020 ). Although dermatophyte infections are restricted to areas of the epidermis, they can be invasive and cause serious widespread infections in immunocompromised patients (Trottier et al 2020 ). Major risk factors for the development of invasive fungal infections include, among others, HIV treatment in AIDS patients, cytotoxic chemotherapy in cancer patients, immunosuppressive therapy where innate defenses have been breached and the presence of catheters and other indwelling devices (Casadevall 2019 ; Li et al 2020 ).…”