“…This blueprint of the HTCE can be summarized in the following five conditions and mechanisms (cf., Cloodt et al, 2016). These conditions and mechanisms also serve to (practically) connect the highly fragmented literature on regional collaboration, innovation hotspots, knowledge sharing, ecosystem development, value chains and related topics (e.g., Boschma, 2005;Chesbrough, 2012;Gilsing, Van Burg, & Romme, 2010;Iansiti & Levien, 2004;Katz & Wagner, 2014;Leten et al, 2013;Nijssen & van der Borgh, 2017;Romme, 1997 …”