Beziehungen zwischen Virus und Rous-Sarkom bei Heterotransplantation

The Sarcomatous Transformation of Mammary Carcinoma, of Mice in Isologous Transplantates, in Cell Cultures, and in Reimplantates

“…Rats grow spindle cell sarcomas, mice sarcomas with unripe cells. The sarcoma cells of mice contain viruses [51]. They could only have been synthetized from the dividing sar coma cells of a growing tumor.…”

“…The tumors of the various strains show structural differences which are due to genetic causes [2,3,10,[16][17][18][49][50][51]. In the older literature the malignancy of these growths had been doubted as their tissue texture was orderly and as they had no métastasés.…”

“…These rings are pushed forward into the intercellular space in cytoplasmatic vacuoles or through microvilli. The cytoplasmatic membrane thus becomes the capsulid of the virus.The osmiophilic ring unwinds itself in the centre into a threadlike RNA molecule, thus becoming the nucleoid of the B-form [25,26],The adenocarcinomatous structure becomes lost in syngenous and allogenous [35] series of transplants [22,23,25,26,29,30,34,[49][50][51]. The tumor by growing wild becomes a polymorphous solid carcinoma simplex.…”