BF₃·OEt₂ catalyzed synthesis of functionalized 9-fluorene-9-ylidene appended quinazolin-4-ones

Abstract

An efficient method for the construction of the quinazolinone skeleton from the reaction of 9-(phenylethynyl)-9H-fluoren-9-ols with substituted 2-aminobenzamides catalyzed by boron trifluoride is achieved. Scope of the reaction with a...

Designing, Synthesis, and Anti‐Breast Cancer Activity of a Series of New Quinazolin‐4(1H)‐one Derivatives

“…In this context, testing several derivatives of quinazolin‐4(1 H )‐one by molecular docking studies appears to be a logical strategy. Since most of the synthetic and natural quinazolinones [22–30] exhibited a remarkable broad spectrum in biological activities including anti‐microbial, [31] anti‐cancer, [32] anti‐convulsant, [33] anti‐bacterial, [34] and anti‐tumor [35] . Several synthetic routes have been reported so far for synthesizing quinazolin‐4(1 H )‐one derivatives using some of the starting materials like isatoic anhydride, ammonium acetate and aldehyde with (AS) as a catalyst, [36,37] anthranilic acid, amine and orthoester in the presence of aluminum nitrate, [38] carbonyl compounds, and 2‐aminobenzonitrile/2‐aminobenzamide in water with a surfactant combined base catalyst, [PEG‐TEA]OH [39] as well as [(4‐SO 3 H)BMIM]HSO 4 as a catalyst [40] .…”