Bgp2, a new member of the carcinoembryonic antigen-related gene family, encodes an alternative receptor for mouse hepatitis viruses

Nédellec, Patrick; Dveksler, Gabriela S.; Daniels, Eugene; Turbide, Claire; Chow, Bernard; Basile, Alexis A.; Holmes, Kathryn V.; Beauchemin, Nicole

doi:10.1128/jvi.68.7.4525-4537.1994

Cited by 122 publications

(138 citation statements)

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“…Among group II coronaviruses, only the receptor for the murine coronavirus (MHV) is known. MHV enter the cell after binding members of the pleiotropic family of carcinoembryonic antigen-cell adhesion molecules (CEACAMs; CD66a) (Chen et al, 1995(Chen et al, , 1997Dveksler et al, 1993;Nedellec et al, 1994). CEACAMs are glycoproteins possessing two or four immunoglobulin-like extracellular domains followed by a transmembrane domain and a cytoplasmic tail (Nedellec et al, 1994).…”

Section: Coronaviruses and The Outbreak Of Sarsmentioning

confidence: 99%

Coronavirus replication and pathogenesis: Implications for the recent outbreak of severe acute respiratory syndrome (SARS), and the challenge for vaccine development

Navas-Martín

Weiss

2004

J Neurovirol

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Section: Coronaviruses and The Outbreak Of Sarsmentioning

confidence: 99%

Coronavirus replication and pathogenesis: Implications for the recent outbreak of severe acute respiratory syndrome (SARS), and the challenge for vaccine development

Navas-Martín

Weiss

2004

J Neurovirol

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“…The HE proteins of group 2 coronaviruses interact either with Neu4,5Ac 2 or sialic acids with O-acetylation at position 9 (Neu5,9Ac 2 ). While human coronaviruses related to the reference strain HCoV OC43 and BCoV specifically interact with Neu5,9Ac 2 via the HE [13,14] and the spike glycoprotein [15], the murine coronavirus strains S and JHM recognize Neu4,5Ac 2 [9] and a cellular glycoprotein termed MHV-receptor or CEACAM 1a [16][17][18][19]. For Influenza C viruses and BCoV it was shown that they utilize Neu5,9Ac 2 as receptor determinant, which may be part of glycoproteins or the sialic-acid-containing gangliosides [14,20].…”

Section: Introductionmentioning

confidence: 99%

Localisation and distribution of O-acetylated N-acetylneuraminic acids, the endogenous substrates of the hemagglutinin-esterases of murine coronaviruses, in mouse tissue

et al. 2006

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Infections by mouse hepatitis viruses result in disease of the liver, the gastrointestinal tract, respiratory tract, and the central nervous system. Coronaviruses related to mouse hepatitis virus express a hemagglutinin-esterase surface glycoprotein, which specifically hydrolyses either 5-N-acetyl-4-O-acetyl neuraminic acid (Neu4,5Ac(2)) or 5-N-acetyl-9-O-acetyl neuraminic acid (Neu5,9Ac(2)). Moreover, these sialic acids represent potential cellular receptor determinants for murine coronaviruses. Until now, the distribution of these sialic acids in mouse brain was not thoroughly investigated. Particularly Neu4,5Ac(2) was not yet found in mouse brain. Using a sensitive method of gas chromatography coupled to mass spectrometry in the electron impact mode of ionization this manuscript demonstrates the occurrence of 13 different sialic acids varying in their alkyl and acyl substituents in mouse tissues including 5-N-acetyl-4-O-acetyl-9-O-lactyl-neuraminic acid (Neu4,5Ac(2)9Lt), 5-N-acetyl-9-O-lactyl-neuraminic acid (Neu5Ac9Lt), 5-N-acetyl-8-O-methyl-neuraminic acid (Neu5Ac8Me) and the 1,7-lactone (Neu5Ac1,7L) of neuraminic acid. Neu4,5Ac(2), relatively abundant in the gut, was present as a minor compound in all tissues, including liver, olfactory lobe, telencephalon, metencephalon and hippocampus. Neu5,9Ac(2) was also found in these tissues, except in the liver. It is suggested that these sialic acids represent the endogenous substrate and receptor determinants for murine coronaviruses.

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“…Several different proteins work as MHV receptors (Chen et al, 1995;Dveksler et al, 1991;Nedellec et al, 1994;Yokomori and Lai, 1992), among which CEACAM1 is the most functional receptor. Two allelic forms are known for CEACAM1, CEACAM1a (MHVR1) and CEACAM1b (MHVR2) (Beauchemin et al, 1999;Dveksler et al, 1993;Yokomori and Lai, 1992).…”

Section: Introductionmentioning

confidence: 99%

Communication between S1N330 and a Region in S2 of Murine Coronavirus Spike Protein Is Important for Virus Entry into Cells Expressing CEACAM1b Receptor

Matsuyama

Taguchi

2002

Virology

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The soluble receptor-resistant (srr) mutants, srr7 and srr11, isolated from a murine coronavirus, mouse hepatitis virus (MHV) JHMV, have an amino acid mutation at positions 1114 (Leu to Phe) and 65 (Leu to His), respectively, in the spike (S) protein. These mutants failed to efficiently infect BHK cells expressing CEACAM1b (BHK-R2), due to their low entry into this cell line, although they infected cells expressing CEACAM1a (BHK-R1) in a manner similar to that of wild-type (wt) JHMV cl-2 (Matsuyama and Taguchi, Virology 273, 80-89, 2000). Following the repeated passage of these mutants through BHK-R2 cells, viruses were no longer isolated from srr11-infected cells, while two distinct mutants, srr7A and srr7B, were obtained from srr7-infected cells. Srr7A and srr7B grew 2 log10 higher than srr7 and induced fusion in BHK-R2 cells, being similar to wt virus. In addition to the amino acid change at position 1114 that stemmed from parental srr7, srr7A and srr7B had mutations around position 280, corresponding to the third region of the S1N330 receptor-binding site (S1N330-III) common to all MHV strains examined thus far. Srr7A and srr7B S proteins showed high fusogenicity in both BHK-R1 and BHK-R2 cells, like the wt virus, while srr7Aa and srr7Ba S proteins, which had mutations in S1N330-III but not at amino acid 1114, exhibited profoundly reduced fusion activity in these cell lines. These findings suggest that communication between S1N330-III and the amino acid at position 1114 is important for efficient fusion activity in BHK-R2 cells. S1N330-III is a possible region in the S1 involved in viral entry into cells.

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Bgp2, a new member of the carcinoembryonic antigen-related gene family, encodes an alternative receptor for mouse hepatitis viruses

Abstract: Murine coronaviruses such as mouse hepatitis virus (MHV) infect mouse cells via cellular receptors that are isoforms of biliary glycoprotein (Bgp) of the carcinoembryonic antigen gene family (G.

Cited by 122 publications

References 44 publications

Coronavirus replication and pathogenesis: Implications for the recent outbreak of severe acute respiratory syndrome (SARS), and the challenge for vaccine development

Coronavirus replication and pathogenesis: Implications for the recent outbreak of severe acute respiratory syndrome (SARS), and the challenge for vaccine development

Localisation and distribution of O-acetylated N-acetylneuraminic acids, the endogenous substrates of the hemagglutinin-esterases of murine coronaviruses, in mouse tissue

Communication between S1N330 and a Region in S2 of Murine Coronavirus Spike Protein Is Important for Virus Entry into Cells Expressing CEACAM1b Receptor

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