Bi- and bisbibenzyls from the roots of Dichapetalum heudelotii and their antiproliferative activities

Osei‐Safo, Dorcas; Dziwornu, Godwin Akpeko; Salgado, Antonio; Sunassee, Suthananda N.; Chama, Mary Anti

doi:10.1016/j.fitote.2017.09.001

Cited by 12 publications

(17 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…eickii , D. fillicauli ( Chama et al., 2015 ) and D . pallidum ( Osei-Safo et al., 2017 ). Dichapetalin M has so far been isolated from only two other species, D .…”

Section: Resultsmentioning

confidence: 99%

“…Pomolic acid has also been isolated from D. fillicauli ( Chama et al., 2015 ) and D . pallidum ( Osei-Safo et al., 2017 ). Earlier isolation of friedelan-3β-ol and friedelan-3-one was reported in D .…”

Section: Resultsmentioning

confidence: 99%

“…madagascariense ( Osei-Safo et al., 2008 ), D. filicaule ( Chama et al., 2015 ) and D . pallidum ( Osei-Safo et al., 2017 ). β-Sitosterol and stigmasterol have previously been isolated from D .…”

Section: Resultsmentioning

confidence: 99%

“…These include the fluorinated carboxylic acids reputed to be responsible for the toxicity of some members of the genus ( Meyer and O'Hagan, 1992 ) as well as various types of triterpenoids including the dichapetalins reputed to have cytotoxic and antiproliferative activities ( Fang et al., 2016 ; Long et al., 2013 ; Osei-Safo et al., 2012 ). Other non-terpenoidal compounds recently reported from the genus are the bisbenzyl derivatives heudelotol A and B from D. heudelotii ( Osei-Safo et al., 2017 ). Additional compound types obtained from the genus are the alkaloid trigonelline, the amino acids N-methylserine and N-methylalanine ( Breteler, 1978 ; Eloff, 1980 ), sugars, various glycosides, esters of (E)-ferulic acid ( Addae-Mensah et al., 2007 ; Adu-Kumi, 1997 ) and pyracrenic acid ( Long et al., 2013 ).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

In vitro activities of crude extracts and triterpenoid constituents of Dichapetalum crassifolium Chodat against clinical isolates of Schistosoma haematobium

Chama

Onyame

Fleischer

et al. 2020

Heliyon

Self Cite

View full text Add to dashboard Cite

Dichapetalum crassifolium Chodat (Dichapetalaceae) is widely distributed in Africa, Tropical Asia and Latin America. As part of our quest for potential bioactive lead compounds for various neglected tropical diseases, we report the anti-schistosomal potential of the crude extracts and chemical constituents of the stems and roots of Dichapetalum crassifolium. Column chromatography of extracts of the stems and roots led to the isolation and identification of three oleanane-type triterpenoids, friedelan-3β-ol (1), friedelan-3-one (2), and maslinic acid (3); the ursane-type tritepenoid, pomolic acid (4) and the dammarane-type tetracyclic triterpenoids, dichapetalin A (5) and dichapetalin M (6). Dichapetalin A was isolated from only the roots. Isolated compounds were identified by comparison of their physico-chemical and spectral data with published data. The highest in vitro anti-schistosomal activity (IC 50 ) of the crude extracts against clinical isolates of Schistosoma haematobium (Bilharz 1852) was 248.6 μg/ml for the ethyl acetate extract of the root while dichapetalin A gave the highest activity at 151.1 μg/ml among the compounds compared with the 15.5 μg/ml for the standard drug, praziquantel. The rest of the compounds showed activities in the order 177.9, 191.0, and 378.1 μg/ml respectively for mixture of β-sitosterol/stigmasterol, dichapetalin M and friedelan-3-one. The least active extract was the methanol extract of the stem (893.7 μg/ml). The constituents of D . crassifolium showed activity against the S . haematobium that are below praziquantel. It is envisaged that the presence of multiple layers and the minute sizes of pores in the egg shells, may preclude penetration of eggs by the compounds.

show abstract

“…eickii , D. fillicauli ( Chama et al., 2015 ) and D . pallidum ( Osei-Safo et al., 2017 ). Dichapetalin M has so far been isolated from only two other species, D .…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

In vitro activities of crude extracts and triterpenoid constituents of Dichapetalum crassifolium Chodat against clinical isolates of Schistosoma haematobium

Chama

Onyame

Fleischer

et al. 2020

Heliyon

Self Cite

View full text Add to dashboard Cite

show abstract

“…[8][9][10] Bioactive dichapetalins and several other compounds have been isolated from Dichapetalum species. [11][12][13][14][15][16] Dichapetalum gelonioides (Roxb.) Engl (Figure 1) is a large shrub or small tree with pubescent branchlets and found distributed in evergreen and semi-evergreen forests as forest undergrowth.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial, antifungal and antioxidant activity of Dichapetalum gelonioides (Roxb.) Engl. (Dichapetalaceae)

Priyanka¹,

Bharadwaj²,

Sachin³

et al. 2018

J. Drug Delivery Ther.

View full text Add to dashboard Cite

Objectives: Dichapetalum gelonioides (Roxb.) Engl. belongs to the family Dichapetalaceae. In the present study, we investigated antibacterial, antifungal and antioxidant activity of methanolic extract of leaf and fruit of D. gelonioides. Methods: Maceration process was carried out for extraction of leaf and fruit of D. gelonioides. Agar well diffusion method was employed to evaluate antibacterial activity of extracts against gram positive and gram negative bacteria. Poisoned food technique was performed to investigate antifungal activity of extracts against two seed-borne fungi. Antioxidant activity was evaluated by DPPH radical scavenging and ferric reducing assays. Results: Both leaf and fruit extracts were effective in causing inhibition of all test bacteria. Highest and least inhibitory activity was observed against Bacillus cereus and Escherichia coli respectively. Both Aspergillus niger and Bipolaris sp. were inhibited to >50% by leaf and fruit extracts. Extent of inhibition of Bipolaris sp. was slightly higher when compared to A. niger. Both leaf and fruit extracts showed a dose dependent scavenging of DPPH radicals with high activity being showed by leaf extract. Leaf extract was shown to exhibit marked reducing potential than fruit extract. Conclusions: Overall, leaf extract was shown to be more effective in displaying antioxidant activity and causing inhibition of bacteria and fungi when compared to fruit extract. The results indicate that the plant possess active principles which are to be purified, characterized and subjected for antimicrobial and antioxidant assays in further studies.

show abstract

Biochemistry of Secondary Metabolism in Plants

Rajčević

Bukvički

Stojković

et al. 2023

Natural Secondary Metabolites

View full text Add to dashboard Cite

Bi- and bisbibenzyls from the roots of Dichapetalum heudelotii and their antiproliferative activities

Cited by 12 publications

References 20 publications

In vitro activities of crude extracts and triterpenoid constituents of Dichapetalum crassifolium Chodat against clinical isolates of Schistosoma haematobium

In vitro activities of crude extracts and triterpenoid constituents of Dichapetalum crassifolium Chodat against clinical isolates of Schistosoma haematobium

Antibacterial, antifungal and antioxidant activity of Dichapetalum gelonioides (Roxb.) Engl. (Dichapetalaceae)

Biochemistry of Secondary Metabolism in Plants

Contact Info

Product

Resources

About