Bi-continuous Mg-Ti interpenetrating-phase composite as a partially degradable and bioactive implant material

Dou, Chenxi; Zhang, Mingyang; Ren, Dechun; Ji, Haibin; Zhou, Yi; Wang, S.G.; Liu, Zengqian; Wang, Qiang; Zheng, Yufeng; Zhang, Zhefeng; Yang, Rui

doi:10.1016/j.jmst.2022.11.011

Cited by 21 publications

(4 citation statements)

References 58 publications

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“…The composite material demonstrated a significant enhancement in the proliferation rate of SAOS-2 osteoblastic bone cells, accompanied by a minimal level of cytotoxicity. Dou et al developed an Mg-Ti composite through the process of pressure-less infiltration, where pure Mg melt was infused into a 3D printed Ti-scaffold [ 124 ]. The composite’s topologically bi-continuous architecture offers higher strengths and lower Young’s modulus compared to dense Ti.…”

Section: Biomedical Metal Fabrication Using 3d Printingmentioning

confidence: 99%

Recent advances in 3D printing of biodegradable metals for orthopaedic applications

Liang,

Zhou,

Zhang

et al. 2023

J Biol Eng

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The use of biodegradable polymers for treating bone-related diseases has become a focal point in the field of biomedicine. Recent advancements in material technology have expanded the range of materials suitable for orthopaedic implants. Three-dimensional (3D) printing technology has become prevalent in healthcare, and while organ printing is still in its early stages and faces ethical and technical hurdles, 3D printing is capable of creating 3D structures that are supportive and controllable. The technique has shown promise in fields such as tissue engineering and regenerative medicine, and new innovations in cell and bio-printing and printing materials have expanded its possibilities. In clinical settings, 3D printing of biodegradable metals is mainly used in orthopedics and stomatology. 3D-printed patient-specific osteotomy instruments, orthopedic implants, and dental implants have been approved by the US FDA for clinical use. Metals are often used to provide support for hard tissue and prevent complications. Currently, 70–80% of clinically used implants are made from niobium, tantalum, nitinol, titanium alloys, cobalt-chromium alloys, and stainless steels. However, there has been increasing interest in biodegradable metals such as magnesium, calcium, zinc, and iron, with numerous recent findings. The advantages of 3D printing, such as low manufacturing costs, complex geometry capabilities, and short fabrication periods, have led to widespread adoption in academia and industry. 3D printing of metals with controllable structures represents a cutting-edge technology for developing metallic implants for biomedical applications. This review explores existing biomaterials used in 3D printing-based orthopedics as well as biodegradable metals and their applications in developing metallic medical implants and devices. The challenges and future directions of this technology are also discussed.

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Section: Biomedical Metal Fabrication Using 3d Printingmentioning

confidence: 99%

Recent advances in 3D printing of biodegradable metals for orthopaedic applications

Liang,

Zhou,

Zhang

et al. 2023

J Biol Eng

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“…Due to their exceptional biocompatibility and mechanical properties, titanium (Ti) and its alloys have been extensively utilized in bone tissue engineering, particularly dentistry. , Although the survival rate of dental implants is reportedly over 90%, the osteointegration capability of Ti implants can be seriously hindered by certain conditions, such as osteoporosis . Oxidative stress (OS), a major cause of several clinical disorders, plays a key role in major events, such as inflammation, fibrosis, and healing, during biomaterial implantation .…”

Section: Introductionmentioning

confidence: 99%

Corrosion and Biological Behaviors of Biomedical Ti–24Nb–4Zr–8Sn Alloy under an Oxidative Stress Microenvironment

Liu,

Yan,

Yang

et al. 2024

ACS Appl. Mater. Interfaces

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Biomaterials can induce an inflammatory response in surrounding tissues after implantation, generating and releasing reactive oxygen species (ROS), such as hydrogen peroxide (H 2 O 2 ). The excessive accumulation of ROS may create a microenvironment with high levels of oxidative stress (OS), which subsequently accelerates the degradation of the passive film on the surface of titanium (Ti) alloys and affects their biological activity. The immunomodulatory role of macrophages in biomaterial osteogenesis under OS is unknown. This study aimed to explore the corrosion behavior and bone formation of Ti implants under an OS microenvironment. In this study, the corrosion resistance and osteoinduction capabilities in normal and OS conditions of the Ti−24Nb−4Zr−8Sn (wt %, Ti2448) were assessed. Electrochemical impedance spectroscopy analysis indicated that the Ti2448 alloy exhibited superior corrosion resistance on exposure to excessive ROS compared to the Ti−6Al−4V (TC4) alloy. This can be attributed to the formation of the TiO 2 and Nb 2 O 5 passive films, which mitigated the adverse effects of OS. In vitro MC3T3-E1 cell experiments revealed that the Ti2448 alloy exhibited good biocompatibility in the OS microenvironment, whereas the osteogenic differentiation level was comparable to that of the TC4 alloy. The Ti2448 alloy significantly alleviates intercellular ROS levels, inducing a higher proportion of M2 phenotypes (52.7%) under OS. Ti2448 alloy significantly promoted the expression of the antiinflammatory cytokine, interleukin 10 (IL-10), and osteoblast-related cytokines, bone morphogenetic protein 2 (BMP-2), which relatively increased by 26.9 and 31.4%, respectively, compared to TC4 alloy. The Ti2448 alloy provides a favorable osteoimmune environment and significantly promotes the proliferation and differentiation of osteoblasts in vitro compared to the TC4 alloy. Ultimately, the Ti2448 alloy demonstrated excellent corrosion resistance and immunomodulatory properties in an OS microenvironment, providing valuable insights into potential clinical applications as implants to repair bone tissue defects.

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“…Inorganic restorative materials have several limitations. Decalcified bone matrix (DBM), bioceramics and metallic materials generally may elicit immune responses and exhibit low bioactivity [ 24 , 25 ]. Although DBM has high porosity and good biocompatibility, its low cell seeding efficiency and poor osteoinductive microenvironment greatly restrict its application in large-scale bone regeneration [ 26 ] .…”

Section: Introductionmentioning

confidence: 99%

Structure-optimized and microenvironment-inspired nanocomposite biomaterials in bone tissue engineering

Lv,

Ji,

Wen

et al. 2024

Burns &Amp; Trauma

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Critical-sized bone defects represent a significant clinical challenge due to their inability to undergo spontaneous regeneration, necessitating graft interventions for effective treatment. The development of tissue-engineered scaffolds and regenerative medicine has made bone tissue engineering a highly viable treatment for bone defects. The physical and biological properties of nanocomposite biomaterials, which have optimized structures and the ability to simulate the regenerative microenvironment of bone, are promising for application in the field of tissue engineering. These biomaterials offer distinct advantages over traditional materials by facilitating cellular adhesion and proliferation, maintaining excellent osteoconductivity and biocompatibility, enabling precise control of degradation rates, and enhancing mechanical properties. Importantly, they can simulate the natural structure of bone tissue, including the specific microenvironment, which is crucial for promoting the repair and regeneration of bone defects. This manuscript provides a comprehensive review of the recent research developments and applications of structure-optimized and microenvironment-inspired nanocomposite biomaterials in bone tissue engineering. This review focuses on the properties and advantages these materials offer for bone repair and tissue regeneration, summarizing the latest progress in the application of nanocomposite biomaterials for bone tissue engineering and highlighting the challenges and future perspectives in the field. Through this analysis, the paper aims to underscore the promising potential of nanocomposite biomaterials in bone tissue engineering, contributing to the informed design and strategic planning of next-generation biomaterials for regenerative medicine.

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Bi-continuous Mg-Ti interpenetrating-phase composite as a partially degradable and bioactive implant material

Cited by 21 publications

References 58 publications

Recent advances in 3D printing of biodegradable metals for orthopaedic applications

Recent advances in 3D printing of biodegradable metals for orthopaedic applications

Corrosion and Biological Behaviors of Biomedical Ti–24Nb–4Zr–8Sn Alloy under an Oxidative Stress Microenvironment

Structure-optimized and microenvironment-inspired nanocomposite biomaterials in bone tissue engineering

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