Bi-directional controlled release of ibuprofen and Mg2+ from magnesium alloys coated by multifunctional composite

Dong, Hongzhou; Li, Qing; Tan, Chiu C.; Bai, Ningning; Cai, Peng

doi:10.1016/j.msec.2016.06.035

Cited by 16 publications

(10 citation statements)

References 39 publications

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“…Contact angle analysis may provide useful information regarding the hydrophilicity and hydrophobicity of a material's surface, which is typically dictated by the chemical composition and surface morphology. As shown from the literature [45,46], hydrophilic surfaces have contact angles between 0 • and 90 • , whereas hydrophobic surfaces have contact angles greater than 90 • .…”

Section: Contact Angle Evaluationmentioning

confidence: 91%

Simultaneously Embedding Indomethacin and Electrodeposition of Polypyrrole on Various CoCr Alloys from Ionic Liquids

et al. 2022

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The aim of the present investigation is the electrochemical deposition of polypyrrole films from choline chloride-based ionic liquids at various potential, period times and simultaneously an indomethacin embedding and release. The electrodeposition films were performed on CoCr commercial type Wirobond C (WBC) and, Heraenium CE (Hera) using as electroprocedures for deposition cyclic voltammetry and chronoamperometry. The morphology of obtained films was investigated using scanning electron microscopy (SEM). An FT-IR investigation of CoCr alloys before and after electrodeposition was able to identify the presence of polymer and drug. The research included an evaluation of the hydrophilic character of all studied samples and their electrochemical characterization in Tanni Zuchi artificial saliva. In the electrochemical study, the following methods have been used: open circuit potential, electrochemical impedance spectroscopy and potentiodynamic polarization. Indomethacin release from the polymeric film was determined using UV-VIS spectra. Based on Fick’s law of diffusion and indomethacin release profile, a kinetic law for release was established and discussed.

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Section: Contact Angle Evaluationmentioning

confidence: 91%

Simultaneously Embedding Indomethacin and Electrodeposition of Polypyrrole on Various CoCr Alloys from Ionic Liquids

et al. 2022

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“…Therefore, the SBF contact angle was examined to get information on the wettability of the surface after each modification, which usually is governed by the chemical composition and surface morphology. Contact angles between 0° and 90° are characteristic to hydrophilic surfaces, while values higher than 90° indicate hydrophobic characteristics [55,56]. As illustrated in Figure 8, the bare NiCr alloys showed significant hydrophobicity, more pronounced for ND alloy.…”

Section: Characterization Of Indo Doped Ppy Coatingsmentioning

confidence: 95%

Electrochemical Synthesis of Polypyrrole and Polypyrrole-Indomethacin Coatings on NiCr Alloys Involving Deep Eutectic Solvents

Golgovici

Cârlan

Popescu

et al. 2020

Metals

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There is an increased interest in the use of the deep eutectic solvents (DESs) as electrolytic media for electrochemical synthesis of conducting polymers, which could influence their characteristics. Moreover, the polypyrrole layers represent an attractive route for pharmaceutical drug release. The paper presents several experimental results regarding the electrodeposition of polypyrrole and of polypyrrole-indomethacin coatings on nickel-chromium NiCr alloy substrates widely used in dentistry, involving DES-based electrolytes, namely eutectic mixtures of choline chloride and malonic acid. This type of electrolyte also allowed an enhanced dissolution of indomethacin as compared to aqueous ones. The electropolymerization process has been investigated by cyclic voltammetry and chronoamperometry. The obtained indomethacin containing polymeric coatings have been thoroughly characterized involving scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, contact angle measurements in simulated body fluid (SBF) and indomethacin release studies. Adherent and uniform polypyrrole-indomethacin layers have been obtained on NiCr alloy substrates. The release tests showed that the polypyrrole coatings containing indomethacin may deliver the drug molecules for longer periods of at least 17 days. The maximum released amount was around 99.6% suggesting these layers may act as an active reservoir for indomethacin. Kinetics analysis based on the Korsmeyer–Peppas model suggested the diffusion of the drug out of the polymer layer as the most probable mechanism governing the release.

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“…Until now, some drug release orthopedic implants based on Mg alloys have been reported containing antibiotics, e.g. antimicrobial peptide [89,90], gentamicin [91], or gentamicin sulfate [92]. Magnesium alloy implants commonly suffer from an easy infection related to implantation along with the high rate of degradation.…”

Section: Magnesium and Composites Containing Mg In Drug Deliverymentioning

confidence: 99%

“…Magnesium alloy implants commonly suffer from an easy infection related to implantation along with the high rate of degradation. Dong et al [89] fabricated a surface drug delivery system based on Mg/Epoxy resin-ZnO/Polycaprolactone (PCL)-Ibuprofen using a dip coating method followed by spraying. It was suggested that the composite coating could be a promising alternative for biodegradable Mg-based drug delivery and implant applications.…”

Section: Magnesium and Composites Containing Mg In Drug Deliverymentioning

confidence: 99%

An overview of the development of composites containing Mg and Zn for drug delivery

Niazvand¹,

Cheshmi

Zand

et al. 2020

jcc

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Bi-directional controlled release of ibuprofen and Mg2+ from magnesium alloys coated by multifunctional composite

Cited by 16 publications

References 39 publications

Simultaneously Embedding Indomethacin and Electrodeposition of Polypyrrole on Various CoCr Alloys from Ionic Liquids

Simultaneously Embedding Indomethacin and Electrodeposition of Polypyrrole on Various CoCr Alloys from Ionic Liquids

Electrochemical Synthesis of Polypyrrole and Polypyrrole-Indomethacin Coatings on NiCr Alloys Involving Deep Eutectic Solvents

An overview of the development of composites containing Mg and Zn for drug delivery

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