Bi-Functional Aspects of Peptide Decorated PLGA Nanocarriers for Enhanced Translocation Across the Blood-Brain Barrier through Macropinocytosis

Resonant Raman-Active Polymer Dot Barcodes for Multiplex Cell Mapping

“…During the formation of Pdots, the hydrolysis of maleic anhydride in PSMA yielded a carboxylic acid, increasing the dispersion stability of Pdots in the aqueous media. All three types of Pdots showed no aggregation or significant changes in the optical properties even after 1 year (Figures S15 and S16), and their dispersion stability in the aqueous media was further confirmed by ζ potential measurements (−27 to −28 mV), which were similar to those of the previously reported colloids with long-term colloidal stability. , …”

“…All three types of Pdots showed no aggregation or significant changes in the optical properties even after 1 year (Figures S15 and S16), and their dispersion stability in the aqueous media was further confirmed by ζ potential measurements (−27 to −28 mV), which were similar to those of the previously reported colloids with long-term colloidal stability. 37,38 As shown in Figure 3b,c, the TTBTRh/PSMA Pdots demonstrated substantially reduced and red-shifted PL emission (λ em = 755 nm) spectra compared to those of TTBTRh in THF, indicating agglomerated TTBTRh molecules in the Pdots. Similarly, red-shifted absorption and emission maxima were observed at 516 and 751 nm for T3TRh/PSMA Pdots and at 532 and 756 nm for TTDI/ PSMA Pdots (Figure 3b and Figure S12).…”

Peptide‐conjugated Nanoparticle Platforms for Targeted Delivery, Imaging, and Biosensing Applications

“…Furthermore, the labile ester bond in the prodrug released free drug in the tumor environment leading to the inhibition of the growth of the tumors. In different studies, CPPs were conjugated to mesoporous silica NPs, [60] polymer NPs,, [61–63] gold nanorods, [64] hepatitis B virus‐like NPs,, [65] and silver NPs [66] for drug delivery applications. The use of targeting and cell penetrating peptides together with NP formulations in different biomedical applications were discussed in some other recent reviews in details, and we refer the readers to these papers [67–69] …”

Food-Derived Peptides: Beneficial CNS Effects and Cross-BBB Transmission Strategies

“…9 Further research has shown that many neuroprotective peptides can be transported across the BBB to the CNS to protect neurons directly and can also be used as carriers to transport functional factor to the CNS. 10 Compared with invasive methods, peptides directly enter the brain through the normal physiological function of brain cells, which can reduce brain damage, and has the advantages of low cost, safety and high efficiency. 11 It provides broad prospects for CNS protection and disease improvement based on these advantages.…”

“…In the mid-1970s, Kastin injected radioisotope-labeled tripeptide melanocyte-stimulating hormone into the rat carotid artery, and detected substantial radioactivity in the rat brain, providing the first evidence that the peptide can penetrate the BBB . Further research has shown that many neuroprotective peptides can be transported across the BBB to the CNS to protect neurons directly and can also be used as carriers to transport functional factor to the CNS . Compared with invasive methods, peptides directly enter the brain through the normal physiological function of brain cells, which can reduce brain damage, and has the advantages of low cost, safety and high efficiency .…”