Bi-functional nature of nanoceria: pro-drug and drug-carrier potentiality towards receptor-mediated targeting of doxorubicin

Abstract

Nanoceria is considered to be one of the promising materials that modulate its pro-and anti-oxidant activity due to tuneable Ce3+/Ce4+ ratio under different physiological conditions. Present study explored the feasibility...

Colloidal stability and catalytic activity of cerium oxide nanoparticles in cell culture media

“…13 The biological application of CeNPs either as potential diagnostic or therapeutic agents depends on their preserved physicochemical properties aer interacting with the cell culture media. [47][48][49] CeNPs coated with polymers such as polyethylene glycol has been reported to exhibit more cytotoxicity than non-coated CeNPs towards breast cancer cells. 49 Research reported in vivo study of erbium-doped CeNPs in treating acute liver injury by reducing the ROS products in the blood, 47 but the effect of these CeNPs cytotoxicity aer cellular uptake is unknown.…”

“…[47][48][49] CeNPs coated with polymers such as polyethylene glycol has been reported to exhibit more cytotoxicity than non-coated CeNPs towards breast cancer cells. 49 Research reported in vivo study of erbium-doped CeNPs in treating acute liver injury by reducing the ROS products in the blood, 47 but the effect of these CeNPs cytotoxicity aer cellular uptake is unknown. Depending on the application, aiming for either more or less cytotoxicity towards the cells needs to be investigated by monitoring the CeNPs physicochemical properties aer entering the cellular environment.…”

pH-Responsive Drug Delivery Nanoplatforms as Smart Carriers of Unsymmetrical Bisacridines for Targeted Cancer Therapy

“…Nevertheless, the most common among these methods remains chemotherapy [ 3 ]. Effective usage of common drugs in chemotherapy is often restricted due to their poor solubility, low biodistribution, systemic circulation as well as aggregation [ 4 ]. In addition, the non-specific delivery of these drugs is often associated with the use of higher doses to achieve the therapeutic dose, which can induce toxic effects on normal cells [ 5 ].…”

Hydrogenated ceria nanoparticles for high-efficiency silicate adsorption

“…Given that their versatile characteristics based on high oxygen storage capacity (OSC) and low redox potential, ceria (CeO 2 ) nanoparticles (NPs) have garnered considerable interest in various fields for applications including solid oxide fuel cells, [1][2][3] UV shielding, 4 gas sensors, 5,6 biomedicine [7][8][9] and chemical mechanical planarization (CMP). [10][11][12][13] The unique properties of CeO 2 are attributed to their low vacancy defect formation energy, which causes oxygen vacancies on the surface of CeO 2 NPs.…”