Bi-functional quercetin/copper nanoparticles integrating bactericidal and anti-quorum sensing properties for preventing the formation of biofilms

Cheng, Jingjing; Zhang, Haixin; Lu, Kunyan; Zou, Yi; Jia, Dongxu; Yang, Hong; Chen, Hong; Zhang, Yanxia; Yu, Qian

doi:10.1039/d4bm00034j

Cited by 15 publications

(3 citation statements)

References 63 publications

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“…Consequently, the nanomaterials formed by the direct assembly of QSIs with bactericidal agents present notable advantages, including a high capacity for both agents and a straightforward fabrication process for antibiofilm applications. For example, Cheng et al fabricated a bifunctional nanoparticle through the coassembly of quercetin (a typical QSI) and copper ion (a biocidal metal ion) in a facile manner (Figure a) . The resulting quercetin/copper nanoparticles (QC NPs) demonstrated minimal cytotoxicity and hemolysis in vitro.…”

Section: Antibiofilm Functional Materials Based On Qs Inhibitionmentioning

confidence: 99%

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Disruption of Communication: Recent Advances in Antibiofilm Materials with Anti-Quorum Sensing Properties

Qu,

Zou,

Wang

et al. 2024

ACS Appl. Mater. Interfaces

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Biofilm contamination presents a significant threat to public health, the food industry, and aquatic/marine-related applications. In recent decades, although various methods have emerged to combat biofilm contamination, the intricate and persistent nature of biofilms makes complete eradication challenging. Therefore, innovative alternative solutions are imperative for addressing biofilm formation. Instead of solely focusing on the eradication of mature biofilms, strategically advantageous measures involve the delay or prevention of biofilm formation on surfaces. Quorum sensing, a communication system enabling bacteria to coordinate their behavior based on population density, plays a pivotal role in biofilm formation for numerous microbial species. Materials possessing antibiofilm properties that target quorum sensing have gained considerable attention for their potential to prevent biofilm formation. This Review consolidates recent research progress on the utilization of materials with antiquorum sensing properties for combating biofilm formation. These materials can be categorized into three distinct types: (i) antibiofilm nanomaterials, (ii) antibiofilm surfaces, and (iii) antibiofilm hydrogels with antiquorum sensing capabilities. Finally, the Review concludes with a brief discussion of current challenges and outlines potential avenues for future research.

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Section: Antibiofilm Functional Materials Based On Qs Inhibitionmentioning

confidence: 99%

Section: Antibiofilm Functional Materials Based On Qs Inhibitionmentioning

confidence: 99%

Disruption of Communication: Recent Advances in Antibiofilm Materials with Anti-Quorum Sensing Properties

Qu,

Zou,

Wang

et al. 2024

ACS Appl. Mater. Interfaces

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, it has some disadvantages, including low water solubility and bioavailability issues. Quercetin/Cu NPs have been found to prevent biofilm formation by disrupting the integrity of the cell membrane and processes involved in QS, and by reducing the expression of lasI , lasR , rhlI , and rhIR genes in P. aeruginosa and agrA and icaA in S. aureus , and are non-toxic to mouse fibroblast cells ( Cheng et al, 2024 ).…”

Section: Nps As Inhibitors Of Biofilm Formationmentioning

confidence: 99%

Targeting bacterial biofilm-related genes with nanoparticle-based strategies

Afrasiabi,

Partoazar

2024

Front. Microbiol.

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Persistent infection caused by biofilm is an urgent in medicine that should be tackled by new alternative strategies. Low efficiency of classical treatments and antibiotic resistance are the main concerns of the persistent infection due to biofilm formation which increases the risk of morbidity and mortality. The gene expression patterns in biofilm cells differed from those in planktonic cells. One of the promising approaches against biofilms is nanoparticle (NP)-based therapy in which NPs with multiple mechanisms hinder the resistance of bacterial cells in planktonic or biofilm forms. For instance, NPs such as silver (Ag), zinc oxide (ZnO), titanium dioxide (TiO2), copper oxide (Cu), and iron oxide (Fe3O4) through the different strategies interfere with gene expression of bacteria associated with biofilm. The NPs can penetrate into the biofilm structure and affect the expression of efflux pump, quorum-sensing, and adhesion-related genes, which lead to inhibit the biofilm formation or development. Therefore, understanding and targeting of the genes and molecular basis of bacterial biofilm by NPs point to therapeutic targets that make possible control of biofilm infections. In parallel, the possible impact of NPs on the environment and their cytotoxicity should be avoided through controlled exposure and safety assessments. This study focuses on the biofilm-related genes that are potential targets for the inhibition of bacterial biofilms with highly effective NPs, especially metal or metal oxide NPs.

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Copper‐Polyphenol Nanocomplexes with Peroxidase‐Like Activity for Enhanced Fungal Eradication

Liu,

Chen,

Huang

et al. 2024

ChemCatChem

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The increasing severity of fungal infections globally and the limited availability of effective treatments necessitate novel therapeutic strategies. In this study, we developed a copper‐polyphenol nanocomplexes (CPE NPs) through a one‐step synthetic process by the coordination self‐assembly of copper sulfate (CuSO4), protocatechuic acid (PA), and ε‐Poly‐L‐lysine (EPL). CPE NPs demonstrated peroxidase‐like activities, which could catalyze H2O2 to generate hydroxyl radicals (•OH) to effectively eradicate fungi. CPE NPs were stable in physiological neutral environment. However, since metal‐phenolic coordination interaction was unstable in acidic pH, CPE NPs could be dissociated in acidic environments, such as fungal infection sites, leading to effective release of Cu2+ and EPL, thereby exerting antifungal effects. CPE NPs exhibited excellent fungicidal ability at both pH 7.4 and 6.0 against Candida albicans and Aspergillus flavus. More importantly, CPE NPs could effectively eradicate fungi in 20% Sabouraud dextrose broth (SDB) medium containing rich inorganic salts and proteins, in which dissociative Cu2+ completely lost its fungicidal ability. In summary, CPE NPs could effectively deliver Cu2+ to fungal surface for enhanced fungal eradication by generating •OH, highlighting their great potential as a promising nano‐therapeutic agent for the treatment of fungal infections.

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Bi-functional quercetin/copper nanoparticles integrating bactericidal and anti-quorum sensing properties for preventing the formation of biofilms

Abstract: Biofilms formed by pathogenic bacteria present a persistent risk to human health. While the eradication of matured biofilms remains a formidable challenge, delaying or preventing their formation, which is coordinately...

Cited by 15 publications

References 63 publications

Disruption of Communication: Recent Advances in Antibiofilm Materials with Anti-Quorum Sensing Properties

Disruption of Communication: Recent Advances in Antibiofilm Materials with Anti-Quorum Sensing Properties

Targeting bacterial biofilm-related genes with nanoparticle-based strategies

Copper‐Polyphenol Nanocomplexes with Peroxidase‐Like Activity for Enhanced Fungal Eradication

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