The Initial Strategy on reduction of greenhouse gas (GHG) emissions from ships adopted by the International Maritime Organization (IMO) in 2018 commits the IMO to reduce total GHG emissions of shipping by at least 50% by 2050. Though the direction of the Strategy is clear, the path to implementation remains uncertain. The ambitious IMO’s target calls for widespread uptake of lower and zero-carbon fuels, in addition to other energy efficiency measures, including operational and market ones. Using a triangulated research approach, this paper provides a critical overview of the main measures and initiatives the shipping industry can adopt to try to cope with the new IMO’s requirements. The pros and cons of the most popular emission reduction options are investigated along with the main challenges and barriers to implementation and the potential facilitators that could foster a wider application. The framework that is outlined is complex and not without controversy. Research can play a key role as a facilitator of shipping’s decarbonization by providing its contribution to overcoming the existing controversies on various decarbonization options and by developing a wealth of knowledge that can encourage the implementation of low-carbon initiatives.