Discovered in 2011, MXene becomes a most recent and active member of two-dimensional materials. Since then, the landscape of MXene grows significantly and now more than 30 different MXenes were obtained experimentally. Though most of the efforts are contributed to Ti-MXenes which have the highest level of maturity of the synthetic technology and productivity, in recent years, new-MXene systems with Molybdenum (Mo), Vanadium (V), and Niobium (Nb) as the transition metals demonstrated their unique properties and applications. The development of new-MXenes not only expands the synthetic methods and applications of MXenes but also faces new challenges. Therefore, a timely summary of Mo-, V-and Nb-MXenes will be extremely beneficial. Here, the synthetic methods of the selected new-MXenes are summarized and their most recent applications are highlighted to provide an outlook for the future development of MXenes.