Biafine Applied on Human Epidermal Wounds Is Chemotactic for Macrophages and Increases the IL1/IL6 Ratio

Abstract

Using a model of pure epidermal wounds in normal human volunteers, we have studied the effects of Biafme® emulsion firstly on inflammatory cell migration, vascular permeability and cytokine release during the first 24 h, and secondly on epidermal wound healing by measuring transepidermal water loss from day 1 to day 7. Under these conditions, Biafme does not improve epidermal healing, in contrast to what is observed with bleeding dermoepidermal wounds. Our results suggest that the effects of Biafine are essentially at the dermis level. The analysis of epidermal wound exudates leads to the same conclusion. As a matter of fact, we demonstrated that Biafine is chemotactic for macrophages and increases the IL-l/IL-6 ratio, chiefly by reducing the secretion of IL-6. This study permits to progressively clarify the mode of action of Biafine, that seems to be located at the level of granulation tissue formation and not at the epidermal level.

Canine acute radiation dermatitis, a survey of current management practices in North America

“…In this survey, 27.8% of facilities used a product designed to restore the skin’s barrier function and promote moist wound healing. These products are thought to act as barriers that preserve moisture, enhance re‐epithelialization, promote enzymatic digestion of necrotic tissue and enhance phagocytosis of necrotic debris and bacteria 34,35 . In addition to promoting wound healing, these dressings cover the wound and protect the area from external contamination and infection and prevent further irritation and friction.…”

A Randomized Controlled Trial of Silver Sulfadiazine, Biafine, and Saline‐soaked Gauze in the Treatment of Superficial Partial‐thickness Burn Wounds in Pigs

“…1 Biafine is an oil-inwater emulsion containing alginate that may be used in the treatment of superficial partial-thickness burns. Biafine has been shown to be chemotactic for macrophages and to increase IL-1/IL-6 ratio in suction blister wounds in human volunteers, 9 suggesting that it may have a role as an anti-inflammatory agent for treatment for cutaneous wounds.…”

“…[2][3][4][5][6][7][8] Biafine (Labortoires Medix, Houdan, France) is an oil-in-water emulsion containing alginate, which may be used in the treatment of superficial partial-thickness burns. A recent study has shown that biafine is chemotactic for macrophages and increases the interleukin (IL)-1/IL-6 ratio in suction blister wounds in human volunteers 9 ; however, it was reported that biafine may cause contact dermatitis. 10 We are unaware of any prior studies comparing the clinical effectiveness of biafine and SSD in the treatment of superficial partial-thickness burns.…”

Treatment of radiation dermatitis in the light of evidence-based medicine

“…Głównym obszarem działania tego preparatu jest skóra właściwa, gdzie poprzez rekrutację makrofagów oraz przez modyfikację stężeń cytokin prozapalnych wpływa na proces gojenia ran [16]. W badaniu RTOG 97-13 pacjentki napromieniane na obszar piersi zrekrutowano do dwóch ramion -w jednym stosowano Biafine 3 razy dziennie od początku radioterapii i 2 tygodnie po zakończeniu, w drugim zaś stosowano środki inne niż Biafine zgodnie ze zwyczajami ośrodka badającego (aloes, Aquaphore).…”