We report the observation of tunneling anisotropic magnetoresistance effect (TAMR) in the epitaxial metal-semiconductor system Fe/GaAs/Au. The observed two-fold anisotropy of the resistance can be switched by reversing the bias voltage, suggesting that the effect originates from the interference of the spin-orbit coupling at the interfaces. Corresponding model calculations reproduce the experimental findings very well. PACS numbers: 73.43.Jn, 72.25.Dc, 73.43.Qt Tunneling magnetoresistance (TMR) devices consist of a tunneling barrier, typically an oxide, sandwiched between two ferromagnetic layers of different coercive fields. Such systems find widespread use in sensor and memory application as they exhibit a large resistance difference for parallel and antiparallel alignment of the ferromagnets' magnetization [1]. The TMR effect relies, within the simplest model [2], on the different spin polarizations at the Fermi energy E F in the ferromagnets; it is absent if one ferromagnetic layer is replaced by a normal metal. Hence it came as a surprise that a spin-valve-like tunnel magnetoresistance was found in (Ga,Mn)As/alumina/Au sandwiches [3]. The origin of the effect, labeled tunneling anisotropic magnetoresistance (TAMR), was associated with the anisotropic density of states in the ferromagnet (Ga,Mn)As. An enhanced anisotropic magnetoresistance (AMR) effect measured across a constriction in a (Ga,Mn)As film was ascribed to the TAMR effect, too [4]. In both experiments the fourfold symmetry, expected if the (Ga,Mn)As hole density of states is involved, was broken and ascribed to strain in (Ga,Mn)As.Here we show that a TAMR effect can also be observed in sandwiches involving a conventional ferromagnet like iron. A stack of Fe, GaAs and Au, with iron grown epitaxially on the GaAs tunneling barrier, shows pronounced spin-valve-like signatures. We observe a uniaxial anisotropy of the tunneling magnetoresistance. Depending on the bias voltage the high resistance state is either observed for the magnetization M oriented in [110] or in [110] direction. We propose a theoretical model in which the C 2v symmetry, resulting from the interference of Bychkov-Rashba and Dresselhaus spin-orbit interactions, is transferred to the tunneling probability, giving rise to the observed two-fold symmetry.A sketch of the system is shown in Fig. 1(a). The 13 nm thick epitaxial iron layer was grown on an 8 nm thin GaAs (001) barrier by transferring the freshly grown GaAs heterojunction from the molecular beam epitaxy chamber to a magnetron sputtering system without breaking the ultrahigh vacuum (UHV). The quality of the interface of a sample from the same wafer was checked by high-resolution transmission electron microscopy [5]. The Fe layer was covered by 50 nm cobalt and 100 nm gold which serves as back contact. The wafer then was glued upside down to another substrate and the original substrate was etched away. Finally, the circular, 150 nm thick top gold contact was made by employing optical lithography, selective etching of AlGa...