Biased Genotype Distributions of<i>Candida albicans</i>Strains Associated with Vulvovaginal Candidosis and Candidal Balanoposthitis in China

Li, Juan; Fan, Shang­rong; Li, Xiaoping; Li, Dongming; Zhen-hua, Nie; Li, Fang; Hua, Lin; Huang, Wenming; Zong, Liu; Jin, Jian; Hong, Lei; Bai, Feng‐Yan

doi:10.1086/592249

Cited by 38 publications

(45 citation statements)

References 33 publications

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“…2. The clustering of C. albicans isolates based on ERG11 sequence analysis is in agreement with that shown in a previous study of ours based on sequence analysis of three housekeeping genes (11). The correlated variations of different gene sequences with CAI genotypes confirm the merit of C. albicans strain typing based on CAI polymorphism.…”

Section: Discussionsupporting

confidence: 90%

“…These two dominant genotypes were rarely found among isolates from extragenital sites (11). In addition, the distribution of the dominant genotypes correlated positively with the severity of VVC (8,11). These results suggested that C. albicans isolates with genotypes CAI 30-45 and CAI 32-46 might be more virulent and/or more resistant to the commonly used azole drugs than those with other genotypes as causative agents of vaginal infection.…”

mentioning

confidence: 89%

“…In contrast, isolates associated with VVC from unrelated patients were more homogeneous and belonged to only a few genotypes, with two genotypes, CAI 30-45 and CAI 32-46, being the most common. These two dominant genotypes were rarely found among isolates from extragenital sites (11). In addition, the distribution of the dominant genotypes correlated positively with the severity of VVC (8,11).…”

mentioning

confidence: 90%

“…Recently, we compared the genotype distribution patterns among independent C. albicans isolates associated with VVC in Chinese women and those from various extragenital sites by using the polymorphic microsatellite locus CAI (8,11). The results showed that the CAI genotypes of C. albicans isolates from extragenital sites were highly diversified.…”

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confidence: 99%

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Correlation between Azole Susceptibilities, Genotypes, and ERG11 Mutations in Candida albicans Isolates Associated with Vulvovaginal Candidiasis in China

Wan

et al. 2010

Antimicrob Agents Chemother

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The relationship between susceptibilities to fluconazole and itraconazole and microsatellite CAI genotypes were examined from a total of 154 Candida albicans isolates (97 isolates causing vulvovaginitis in Chinese women and 6 vaginal isolates and 51 oral cavity isolates from asymptomatic carriers). The two dominant genotypes, CAI 30-45 (45 isolates) and CAI 32-46 (33 isolates), associated with vulvovaginitis showed significantly different azole susceptibility patterns with strong statistical support. CAI 32-46 isolates were usually less susceptible to both fluconazole and itraconazole than CAI 30-45 isolates and than the oral isolates with other diversified CAI genotypes. Remarkably different mutation patterns in the azole target gene ERG11 were correspondingly observed among C. albicans isolates representing different genotypes and sources. Isolates with the same or similar CAI genotypes usually possessed identical or phylogenetically closely related ERG11 sequences. Loss of heterozygosity in ERG11 was observed in all the CAI 32-46 isolates but not in the CAI 30-45 isolates and most of the oral isolates sequenced. Compared with the ERG11 sequence of strain SC5314 (X13296), two homozygous missense mutations (G487T and T916C) leading to two amino acid changes (A114S and Y257H) in Erg11p were found in CAI 32-46 isolates. The correlation between azole susceptibility and C. albicans genotype may be of potential therapeutic significance.

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Section: Discussionsupporting

confidence: 90%

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confidence: 89%

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confidence: 90%

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confidence: 99%

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Correlation between Azole Susceptibilities, Genotypes, and ERG11 Mutations in Candida albicans Isolates Associated with Vulvovaginal Candidiasis in China

Wan

et al. 2010

Antimicrob Agents Chemother

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“…When analyzing the genetic diversities of human fungal pathogens, for instance, Histoplasma capsulatum (25), Candida albicans (26), Aspergillus fumigatus (23), and Cryptococcus neoformans (27), it has been demonstrated that SNP analyses were highly discriminative in these species. Based on multilocus sequence analyses (MLSAs), genetic diversity in plant-pathogenic fungi was also reported for Magnaporthe grisea and Ustilaginoidea virens (28,29).…”

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confidence: 99%

Population Genetics of Hirsutella rhossiliensis, a Dominant Parasite of Cyst Nematode Juveniles on a Continental Scale

Wang

Zhang

Jiang

et al. 2016

Appl Environ Microbiol

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Hirsutella rhossiliensis is a parasite of juvenile nematodes, effective against a diversity of plant-parasitic nematodes. Its global distribution on various nematode hosts and its genetic variation for several geographic regions have been reported, while the global population genetic structure and factors underlying patterns of genetic variation of H. rhossiliensis are unclear. In this study, 87 H. rhossiliensis strains from five nematode species (Globodera sp., Criconemella xenoplax, Rotylenchus robustus, Heterodera schachtii, and Heterodera glycines) in Europe, the United States, and China were investigated by multilocus sequence analyses. A total of 280 variable sites (frequency, 0.6%) at eight loci and six clustering in high accordance with geographic populations or host nematode-associated populations were identified. Although H. rhossiliensis is currently recognized as an asexual fungus, recombination events were frequently detected. In addition, significant genetic isolation by geography and nematode hosts was revealed. Overall, our analyses showed that recombination, geographic isolation, and nematode host adaptation have played significant roles in the evolutionary history of H. rhossiliensis. IMPORTANCEH. rhossiliensis has great potential for use as a biocontrol agent to control nematodes in a sustainable manner as an endoparasitic fungus. Therefore, this study has important implications for the use of H. rhossiliensis as a biocontrol agent and provides interesting insights into the biology of this species.

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Current awareness on yeast

2009

Yeast

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In order to keep subscribers up‐to‐date with the latest developments in their field, this current awareness service is provided by John Wiley & Sons and contains newly‐published material on yeasts. Each bibliography is divided into 10 sections. 1 Reviews; 2 General; 3 Biochemistry; 4 Biotechnology; 5 Cell Biology; 6 Gene Expression; 7 Genetics; 8 Physiology; 9 Medical Mycology; 10 Recombinant DNA Technology. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted. (7 weeks journals ‐ search completed 11th. Feb. 2009)

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Biased Genotype Distributions ofCandida albicansStrains Associated with Vulvovaginal Candidosis and Candidal Balanoposthitis in China

Cited by 38 publications

References 33 publications

Correlation between Azole Susceptibilities, Genotypes, and ERG11 Mutations in Candida albicans Isolates Associated with Vulvovaginal Candidiasis in China

Correlation between Azole Susceptibilities, Genotypes, and ERG11 Mutations in Candida albicans Isolates Associated with Vulvovaginal Candidiasis in China

Population Genetics of Hirsutella rhossiliensis, a Dominant Parasite of Cyst Nematode Juveniles on a Continental Scale

Current awareness on yeast

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