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Jaklovsky, Jozef

doi:10.1007/978-1-4684-9990-2_1

Cited by 1 publication

(2 citation statements)

References 2,771 publications

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“…In MRI, contrast agents (which are usually paramagnetic substances) modify the T 1 and T 2 relaxation times, altering the contrast of the image. The use of contrast agents has greatly enhanced the scope of MRI and enabled probing of different tumors …”

Section: Mitochondria-targeted Agents In Imagingmentioning

confidence: 99%

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Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications

Zielonka¹,

Joseph²,

et al. 2017

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Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases. Currently, the most effective way to deliver drugs specifically to mitochondria is by covalent linking a lipophilic cation such as an alkyltriphenylphosphonium moiety to a pharmacophore of interest. Other delocalized lipophilic cations, such as rhodamine, natural and synthetic mitochondria-targeting peptides, and nanoparticle vehicles, have also been used for mitochondrial delivery of small molecules. Depending on the approach used, and the potentials of cell and mitochondrial membranes, more than 1000-fold higher mitochondrial concentration can be achieved. Mitochondrial targeting has been developed to study mitochondrial physiology and dysfunction and the interaction between mitochondria and other subcellular organelles and for treatment of a variety of diseases such as neurodegeneration and cancer. In this review, we discuss efforts to target small-molecule compounds to mitochondria for probing mitochondria function, as diagnostic tools and potential therapeutics. We describe the physicochemical basis for mitochondrial accumulation of lipophilic cations, synthetic chemistry strategies to target compounds to mitochondria, mitochondrial probes and sensors, and examples of mitochondrial targeting of bioactive compounds. Finally, we review published attempts to apply mitochondria-targeted agents for the treatment of cancer and neurodegenerative diseases.

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Section: Mitochondria-targeted Agents In Imagingmentioning

confidence: 99%

“…The use of contrast agents has greatly enhanced the scope of MRI and enabled probing of different tumors. 671 The paramagnetic nitroxides have long been proposed as potential contrast agents. 672 However, their modest relaxivity when compared to gadolinium (Gd)-based contrast agents hindered their translation into clinical use.…”

Section: Chemical Reviewsmentioning

confidence: 99%