Bibliometric Analysis of Cathepsin B Research From 2011 to 2021

Abstract

Cathepsin B (CTSB) is a lysosomal protease implicated in the progression of various diseases. A large number of CTSB-related studies have been conducted to date. However, there is no comprehensive bibliometric analysis on this subject. In our study, we performed quantitative analysis of CTSB-related publications retrieved from the Science Citation Index Expanded (SCIE) of the Web of Science Core Collection (reference period: 2011–2021). A total of 3,062 original articles and reviews were retrieved. The largest number of publications were from USA (n = 847, 27.66%). The research output of each country showed positive correlation with gross domestic product (GDP) (r = 0.9745, P < 0.0001). Active collaborations between countries/regions were also observed. Reinheckel T and Sloane BF were perhaps the most impactful researchers in the research landscape of CTSB. Plos ONE was the most prevalent (119/3,062, 3.89%) and cited journal (3,021 citations). Comprehensive analysis of the top citations, co-citations, and keywords was performed to acquire the theoretical basis and hotspots of CTSB-related research. The main topics included CTSB-related cancers and inflammatory diseases, CTSB-associated cell death pattern, and the applications of CTSB. These results provide comprehensive insights into the current status of global CTSB-related research especially in pancreas, which is worthy of continued follow-up by practitioners and clinicians in this field.

Radioactive and Fluorescent Dual Modality Cysteine Cathepsin B Activity-Based Probe for Cancer Theranostics

“…23 However, few of CTS-B inhibitors have been used in clinical studies in recent years, and it still has a long way to go. 24,25 This is mainly due to the complexity of the cathepsin web and the integration and functionality of cathepsins within the web. 6,26 Moreover, in addition to the direct cytotoxic effects on the cancer cells, CTS-B inhibitors also have systemic side effects and drug resistance.…”

“…For example, CA074 is an epoxide succinyl inhibitor, which can bind to CTS-B irreversibly and decrease the invasion ability of tumor cells . However, few of CTS-B inhibitors have been used in clinical studies in recent years, and it still has a long way to go. , This is mainly due to the complexity of the cathepsin web and the integration and functionality of cathepsins within the web. , Moreover, in addition to the direct cytotoxic effects on the cancer cells, CTS-B inhibitors also have systemic side effects and drug resistance. On the other hand, targeted radionuclide therapy is an effective therapy approach that delivers ionizing radiation to kill cancer cells physically by a radionuclide-labeled targeting molecule, which has achieved unprecedented success in cancer therapy. , From our preliminary evaluation, the radiation therapeutic ability of 90 Y-BMX2 may provide an effective cancer treatment approach that targets CTS-B.…”

Spatial Mapping of Genes Implicated in SARS-CoV-2 Neuroinvasion to Dorsolateral Prefrontal Cortex Gray Matter

“…FURIN, a proprotein convertase, is located at chromosome 15q26.1 [35]. The CTSB gene, a lysosomal protease, is positioned at chromosome 8p22 [36], while chromosome 8q24.3 contains the LY6E gene [37]. Single-nucleus transcriptomic analyses revealed that there was an elevated expression of SARS-CoV-2 host factors, BSG and FURIN, and antiviral defense genes, LY6E, IFITM2, IFITM3, and IFNAR1, in the brain endothelial cells of patients with Alzheimer's disease, signifying a potential role for microvascular brain injury in the cognitive impairment of COVID-19 [38].…”