The fourth industrial revolution has boosted theory and technology up to the point of replicating human intelligence. Humankind generates enormous amounts of data that need to be stored, systematized, and applied to solve problems that improve daily life. This industrial revolution, also known as Industry 4.0, meets said need through practical applications in numerous fields such as medicine, commerce, robotics, transportation, tourism, and others. This study used the methodology of bibliometric analysis by using the Scopus database, aiming to evaluate the use of Industry 4.0 in South American countries in the last decade and its contribution to physics through the application of data mining tools. RStudio’s Biblioshiny software and VOSviewer were used to categorize and evaluate the contributions of some authors and countries. As a result, the use of remote sensing and machine learning technologies was found to be the most relevant. This bibliometric study provides a recent vision of Industry 4.0 to encourage its use for future research in South American countries.