Bibliometric Analysis of Marine Traditional Chinese Medicine in Pharmacopoeia of the People’s Republic of China: Development, Differences, and Trends Directions

Abstract

Background. Marine traditional Chinese medicine (MTCM) is a class of traditional medicine that has antitumor, anti-inflammatory, and antiviral properties. Bibliometric approaches were used in this study to conduct systematic research in order to gain a complete picture of MTCM research around the world. Methods. CiteSpace and NoteExpress software were utilized as tools to examine the information about authors, sources, keywords, etc. Chinese publications were collected from the CNKI, VIP, and WANFANG databases; English publications were collected from the Web of Science database. Results. A total of 10080 publications were screened, and the search volume of Chinese literature is greater than that of English literature; Nanjing University of Chinese Medicine, China, and Jeju National University, South Korea, published a greater number of articles than other institutions; the scholars Zhaohui-Zhang and Youjin-Jeon have published the highest number of articles in the world. MTCM of shells was often researched for inorganic elements, and data mining methods were applied frequently; MTCM of animals was commonly used for antifatigue and was taken authenticity identification owing to the scarcity of resources; scholars conducted the most research on MTCM of plants, this category usually for antitumor, anti-inflammatory, and antioxidant purposes, and the mechanisms of action were studied in depth. The Chinese literature has undertaken a multifaceted research study based on the theories of processing and the nature of TCM. In the English literature, in-depth studies have been done from the perspectives of the mechanism of action, the extraction and purification of active substances, etc. Conclusions. According to the analysis of keywords, different medicinal parts present their own special research directions, and different research hotspots have also emerged under different medical theories. The development of MTCM is moving in the direction of standardization and modernization, thanks to the development of cross-disciplinary research as well as the use of several new technologies and statistical techniques.

Exploring the Antidepressant Mechanism of Codonopsis pilosula through Network Pharmacology and Molecular Docking Analysis

“…In recent years, traditional Chinese medicine has demonstrated efficacy in depression management, characterized by its favorable safety profile, consistent efficacy, minimal toxicity and adverse effects, and cost-effectiveness 18 . Notably, Codonopsis pilosula, derived from the dry roots of Platycodonaceae Codonopsis pilosula, Suhua Codonopsis pilosula and Sichuan Codonopsis pilosula, exhibits various pharmacological benefits such as anti-stress, anti-aging, gastroprotective, anti-fatigue, and anti-hypoxic properties attributed to its antioxidant effects 11,12 . This study employs network pharmacology in conjunction with molecular docking techniques to elucidate the intricate network interactions of LBT in the context of antidepressant therapy.…”

“…Consequently, a systematic exploration and elucidation of the mechanisms underpinning traditional Chinese medicine assume critical significance. Codonopsis pilosula, derived from the dried root of Codonopsis pilosula Nannf or Codonopsis tangshen Oliv, is a traditional tonic in Chinese medicine renowned for its therapeutic properties 11 . This botanical remedy is rich in sugars, alkaloids, polyacetylenes, glycosides, terpenes, and other bioactive constituents.…”

Chemical Constituents of the Marine Traditional Chinese Medicine of Pegasus laternarius Cuvier (Hai-E Yu)

“…The in vitro cellular studies have also suggested that the water-soluble Margaritifera concha protein has a strong effect on stimulating the differentiation of bone marrow stromal cells into osteoblasts and increased osteoblast proliferation. 3 Notably, a type of sulfated polysaccharide derived from seaweed has been used clinically for cardiovascular diseases, and sodium oligomannate (GV-971), an oligosaccharide compound derived from brown algae, has been used for the treatment of Alzheimer's disease by targeting the brain-gut axis. 4 Therefore, it is of great value to discover novel compounds with diverse biological activities from MTCMs.…”

Ephedra sinica polysaccharide regulate the anti-inflammatory immunity of intestinal microecology and bacterial metabolites in rheumatoid arthritis

“…It has long been used as an herbal medicine in China relieving colds, edema, nasal congestion, and rheumatoid arthritis. Ephedra has anti-inflammatory properties ( Cao et al, 2022 ). Ephedra sinica polysaccharide (ESP) exhibits a good therapeutic effect on RA ( Zheng et al, 2023 ) by reducing the lipopolysaccharide stimulated nuclear translocation of the NF-κB p65 subunit, improving the levels of RA inflammatory markers, and reducing the release of inflammatory factors (TNF-α, IL-1β, and IL-6) and NO by inhibiting the TLR4 signaling pathway ( Li et al, 2023 ).…”