Bibliometric analysis of research on neurodegenerative diseases and single-cell RNA sequencing: Opportunities and challenges

Wang, Wei; Li, Tianhua; Wang, Zheng; Yin, Yaxin; Zhang, Sitao; Wang, Chaodong; Hu, Xinli; Lu, Shibao

doi:10.1016/j.isci.2023.107833

Cited by 6 publications

(3 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Next‐generation sequencing (NGS) and mass spectrometry, renowned for their precision and comprehensive analysis, are commonly used for identifying rRNA modifications. The strength of NGS lies in its high throughput capabilities and shorter read lengths, which are particularly suitable for detecting a wide array of rRNA modifications 61 . There are typically three NGS‐based approaches used for detecting rRNA modifications.…”

Section: Types Of Rrna Modification and Detection Techniquesmentioning

confidence: 99%

“…The strength of NGS lies in its high throughput capabilities and shorter read lengths, which are particularly suitable for detecting a wide array of rRNA modifications. 61 There are typically three NGS‐based approaches used for detecting rRNA modifications. The first method detects naturally occurring modified nucleotides through reverse transcription signatures, revealing changes in modified nucleotides readout caused by RNA‐dependent RNA polymerase during primer extension, exemplified by the conversion of adenosine to inosine.…”

Section: Types Of Rrna Modification and Detection Techniquesmentioning

confidence: 99%

See 1 more Smart Citation

Decoding the ribosome's hidden language: rRNA modifications as key players in cancer dynamics and targeted therapies

Cui,

Zheng,

Lin

et al. 2024

Clinical & Translational Med

View full text Add to dashboard Cite

Ribosomal RNA (rRNA) modifications, essential components of ribosome structure and function, significantly impact cellular proteomics and cancer biology. These chemical modifications transcend structural roles, critically shaping ribosome functionality and influencing cellular protein profiles. In this review, the mechanisms by which rRNA modifications regulate both rRNA functions and broader cellular physiological processes are critically discussed. Importantly, by altering the translational output, rRNA modifications can shift the cellular equilibrium towards oncogenesis, thus playing a key role in cancer development and progression. Moreover, a special focus is placed on the functions of mitochondrial rRNA modifications and their aberrant expression in cancer, an area with profound implications yet largely uncharted. Dysregulation in these modifications can lead to metabolic dysfunction and apoptosis resistance, hallmark traits of cancer cells. Furthermore, the current challenges and future perspectives in targeting rRNA modifications are highlighted as a therapeutic approach for cancer treatment. In conclusion, rRNA modifications represent a frontier in cancer research, offering novel insights and therapeutic possibilities. Understanding and harnessing these modifications can pave the way for breakthroughs in cancer treatment, potentially transforming the approach to combating this complex disease.

show abstract

Section: Types Of Rrna Modification and Detection Techniquesmentioning

confidence: 99%

Section: Types Of Rrna Modification and Detection Techniquesmentioning

confidence: 99%

Decoding the ribosome's hidden language: rRNA modifications as key players in cancer dynamics and targeted therapies

Cui,

Zheng,

Lin

et al. 2024

Clinical & Translational Med

View full text Add to dashboard Cite

show abstract

“…This exclusion criterion was mainly used to limit the range of the authors, cited references, and keywords (Xu G et al, 2021;de Oliveira et al, 2023). If necessary, the authors read the full text to further screen for appropriate literature and discuss different views (Xu G et al, 2021;Wang et al, 2023). Finally, we obtained and analysed 948 documents.…”

Section: Data Strategy and Screening Criteriamentioning

confidence: 99%

Bibliometric analysis of PTEN in neurodevelopment and neurodegeneration

Zhang,

Tan,

Wang

et al. 2024

Front. Aging Neurosci.

View full text Add to dashboard Cite

Phosphatase and tensin homologue deleted on chromosome ten (PTEN) was initially recognized as a significant regulator of cancer suppression and could impede cancer cell survival, proliferation, and energy metabolism. PTEN is highly expressed in neurons and performs crucial functions in neurogenesis, synaptogenesis, and neuronal survival. Disruption of PTEN activity may also result in abnormal neuronal function and is associated with various neurological disorders, including stroke, seizures, and autism. Although several studies have shown that PTEN is involved in the development and degenerative processes of the nervous system, there is still a lack of in-depth studies that summarize and analyse patterns of cooperation between authors, institutions, countries, and journals, as well as research hotspots and trends in this important field. To identify and further visualize the cooperation and comprehend the development and trends of PTEN in the nervous system, especially in neural development and neurological diseases, we used a bibliometric analysis to identify relevant publications on this topic. We first found that the number of publications displayed a growing trend with time, but this was not stable. Universities, institutions, and authors from the United States are leading in this area of research. In addition, many cutting-edge research results have been discovered, such as key regulatory molecules and cellular mechanisms of PTEN in the nervous system, which may provide novel intervention targets and precise therapeutic strategies for related pathological injuries and diseases. Finally, the literature published within the last 5 years is discussed to identify future research trends regarding PTEN in the nervous system. Taken together, our findings, analysed using bibliometrics, may reflect research hotspots and trends, providing a reference for studying PTEN in the nervous system, especially in neural development and neurological diseases. These findings can assist new researchers in developing their research interests and gaining basic information. Moreover, our findings also may provide precise clinical guidelines and strategies for treating nervous system injuries and diseases caused by PTEN dysfunction.

show abstract

Heterogeneity in extracellular matrix and immune microenvironment of anterior vaginal wall revealed by single-cell sequencing in women with stress urinary incontinence

Zhang,

Wang

et al. 2024

Experimental Cell Research

View full text Add to dashboard Cite

Bibliometric analysis of research on neurodegenerative diseases and single-cell RNA sequencing: Opportunities and challenges

Cited by 6 publications

References 50 publications

Decoding the ribosome's hidden language: rRNA modifications as key players in cancer dynamics and targeted therapies

Decoding the ribosome's hidden language: rRNA modifications as key players in cancer dynamics and targeted therapies

Bibliometric analysis of PTEN in neurodevelopment and neurodegeneration

Heterogeneity in extracellular matrix and immune microenvironment of anterior vaginal wall revealed by single-cell sequencing in women with stress urinary incontinence

Contact Info

Product

Resources

About