Bibliometric Review on New Possibilities of Antimycobacterial Agents: Exploring Siderophore Desferrioxamine’s Applications as an Antimicrobial Agent

Abstract

Mycobacteria cause tuberculosis and other serious diseases. Understanding their mechanisms of resistance to our immune system and exploring novel drugs are critical strategies to combat infections. A bibliometric analysis was performed to identify publication trends and critical research areas in the field of the antimicrobial activity of desferrioxamine. A total of twenty-four publications on the topic, from 2012 to 2023, were retrieved from databases including Web of Science, Scopus, PubMed, and Embase, using specific keywords. The quality of the publications was assessed using impact and productivity metrics, with an average annual publication rate of 2.1 articles. The United States emerged as the most productive country, with medicine (23.4%, 11 publications) and biochemistry, genetics, and molecular biology (21.3%, 10 publications) as the top research fields. The five most cited publications accounted for 672 citations, with a relatively low h-index (11:11). In conclusion, there has been a lack of publications on this topic in the last decade. The United States dominates production and publication in this area, and there appears to be limited exchange of knowledge, ideas, and technology within the field. Therefore, fostering international cooperation through funding is essential to facilitate further research and development of desferrioxamine-related studies.

Bibliometric analysis of PTEN in neurodevelopment and neurodegeneration

“…Next, two authors independently screened the literature based on the titles and abstracts to exclude studies unrelated to the topic of interest. This exclusion criterion was mainly used to limit the range of the authors, cited references, and keywords (Xu G et al, 2021;de Oliveira et al, 2023). If necessary, the authors read the full text to further screen for appropriate literature and discuss different views (Xu G et al, 2021;Wang et al, 2023).…”

Structural Study of a New MbtI-Inhibitor Complex: Towards an Optimized Model for Structure-Based Drug Discovery

“…1 H NMR (300 MHz, DMSO-d 6 /D 2 O) δ (ppm) 7.45 (dd, J = 8.0, 1.6 Hz, 1H, E-H Ar ), 7.40 (dd, J = 8.0, 1.6 Hz, 1H, Z-H Ar ), 7.00 (dd, J = 8.0, 1.6 Hz, 1H, E-H Ar ), 6.85 (dd, J = 8.0, 1.6 Hz, 1H, Z-H Ar ), 6.80-6.69 (m, 2H, E-H Ar + Z-H Ar ), 6.61 (q, J = 7.1 Hz, 1H, Z-CH), 5.80 (q, J = 7.5 Hz, 1H, E-CH), 1.96 (d, J = 7.5 Hz, 3H, E-CH 3 ), 1.67 (d, J = 7.1 Hz, 3H, Z-CH 3 ). 13…”

“…Nevertheless, many pathogens, mainly bacteria and fungi, have developed efficient countermeasures to compensate for this effect [10][11][12]. In mycobacteria, one of the most important iron acquisition pathways relies on the production of siderophores [3,6,13]. These low-molecular-weight chelators, known as carboxymycobactins (cMBTs) and mycobactins (MBTs), share a common core but differ in their terminal portion, leading to different solubility and functional properties.…”