Bibliometric Study of Adaptogens in Dermatology: Pharmacophylogeny, Phytochemistry, and Pharmacological Mechanisms

Abstract

Background: Adaptogens are a class of medicinal plants that can nonspecifically enhance human resistance. Most of the plant adaptogens have relevant applications in dermatology, but there are still few studies related to their particular action and co-operative mechanisms in topical skin application. Methods: Plant adaptogens related articles and reviews that published between 1999 and 2022 were obtained from the Web of Science Core Collection database. Various bibliographic elements were collected, including the annual number of publications, countries/regions, and keywords. CiteSpace, a scientometric software, was used to conduct bibliometric analyses. Also, the patsnap global patent database was used to analyze the patent situation of plant adaptogens in the field of cosmetics up to 2021. Results: We found that the effects of plant adaptogens on skin diseases mainly involve atopic dermatitis, acne, allergic contact dermatitis, psoriasis, eczema, and androgenetic alopecia, etc. And the effects on skin health mainly involve anti-aging and antiphotoaging, anti-bacterial and anti-fungal, anti-inflammatory, whitening, and anti-hair loss, etc. Also, based on the results of patent analysis, it is found that the effects of plant adaptogens on skin mainly focus on aging retardation. The dermatological effects of plant adaptogens are mainly from Fabaceae Lindl., Araliaceae Juss. and Lamiaceae Martinov., and their mainly efficacy phytochemical components are terpenoids, phenolic compounds and flavonoids. Conclusion:The plant adaptogens can repair the skin barrier and maintain skin homeostasis by regulating the skin HPA-like axis, influencing the oxidative stress pathway to inhibit inflammation, and regulating the extracellular matrix (ECM) components to maintain a dynamic equilibrium, ultimately achieving the treatment of skin diseases and the maintenance of a healthy state.

NAD-Driven Sirtuin Activation by Cordyceps sinensis Extract: Exploring the Adaptogenic Potential to Promote Skin Longevity

“…Adaptogens are substances that help the body adapt to stressors and enhance their performance [16][17][18] by promoting balance and resilience without causing significant side effects. Fungi, like Ganoderma lucidum (Lingzhi), Cordyceps sinensis (Dong Chong Xia Cao), Lentinula edodes (Shiitake), Auricularia auricula-judae (Wood Ear), Trametes versicolor (Yunzhi), and Tremella fuciformis (Silver Ear), with their high contents of bioactive compounds, such as polysaccharides [19], triterpenoids [20], flavonoids and phenolic compounds [21], have been utilized in TCM for centuries to bolster the body's defenses, enhance vitality, and restore equilibrium, with beneficial effects on the aging process by supporting longevity and vitality [22,23].…”

Food Supplements for Skin Health: In Vitro Efficacy of a Combination of Rhodiola rosea, Tribulus terrestris, Moringa oleifera and Undaria pinnatifida on UV-Induced Damage

“…An increasing body of evidence points at nutraceuticals for the prevention of agingassociated skin changes [15][16][17] and natural extracts are currently being investigated for their potential inhibiting action on aging [18,19]. Several natural leaves-including moringa, curry, guava, ginko biloba, olive, grape, green tea, Tribulus terrestris, wakame and roseroot leaves-have been widely studied for their benefits in the setting of aging science [20,21].…”

ОПЫТ КУЛЬТИВИРОВАНИЯ ЛЕВЗЕИ САФЛОРОВИДНОЙ Rhaponticum carthamoides (Willd.) Iliin В КАЧЕСТВЕ РЕСУРСНОГО ИСТОЧНИКА ЭКДИСТЕРОНА В УСЛОВИЯХ АРХАНГЕЛЬКОЙ ОБЛАСТИ

“…Оно не токсично и не имеет противопоказаний при использовании (5). В фармакопее других стран Европы, Азии и Америки этот вид в настоящее время отсутствует (6,7).…”