Bicarbonate and the Renal Regulation of Acid Base Balance

Pitts, Robert F.; Lotspeich, William D.

doi:10.1152/ajplegacy.1946.147.1.138

Cited by 211 publications

(90 citation statements)

References 8 publications

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“…Numerous clearance studies have examined the effect of acutely increasing plasma bicarbonate concentration on bicarbonate absorption (1,(3)(4)(5) (9). The In previous studies, the rate of proton secretion was examined as a function of luminal bicarbonate concentration (9).…”

Section: Resultsmentioning

confidence: 99%

“…Numerous clearance and micropuncture studies have attempted to examine the effects of systemic bicarbonate concentration and ECF' volume status on acidification (1)(2)(3)(4)(5)(6)(7)(8). In these studies, however, as plasma bicarbonate concentration or ECF volume were altered, there were simultaneous changes in luminal bicarbonate concentration and/or flow rate.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of extracellular fluid volume and plasma bicarbonate concentration on proximal acidification in the rat.

Alpern¹,

Cogan²,

Rector³

1983

J. Clin. Invest.

103

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A B S T R A C T The effects of systemic bicarbonate concentration and extracellular fluid volume status on proximal tubular bicarbonate absorption, independent of changes in luminal composition and flow rate, were examined with in vivo luminal microperfusion of rat superficial proximal convoluted tubules. Net bicarbonate absorption and bicarbonate permeability were measured using microcalorimetry. From these data, net bicarbonate absorption was divided into two parallel components: proton secretion and passive bicarbonate diffusion.The rate of net bicarbonate absorption was similar in hydropenic and volume-expanded rats when tubules were perfused with 24 mM bicarbonate, but was inhibited in volume-expanded rats when tubules were perfused with 5 mM bicarbonate. Volume expansion caused a 50% increase in bicarbonate permeability, which totally accounted for the above inhibition. The rate of proton secretion was unaffected by volume expansion in both studies.The rate of net bicarbonate absorption was markedly inhibited in alkalotic expansion as compared with isohydric expansion. Bicarbonate permeabilities were not different in these two conditions, and the calculated rates of proton secretion were decreased by >50% in alkalosis. Net bicarbonate absorption was stimulated in acidotic rats compared to hydropenic rats. This stimulation was attributable to a 25% increase in the rate of proton secretion.We conclude that (a) proton secretion is stimulatedPortions of this study were presented at the 13th, 14th, and 15th Annual Meetings of the American Society of Nephrology and were published in abstract

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of extracellular fluid volume and plasma bicarbonate concentration on proximal acidification in the rat.

Alpern¹,

Cogan²,

Rector³

1983

J. Clin. Invest.

103

View full text Add to dashboard Cite

show abstract

“…There have been proposed two mechanisms for the production of carbon dioxide: One insists that hydrogen ion (H+) secreted in the distal tubule reacts with bicarbonate in the tubular luminal fluid, forming carbonic acid, the dehydration of which produces carbon dioxide (Pitts and Lotspeich 1946). A high level of UpCO2 as seen in alkalinuria can disappear with the administration of carbonic anhydrase.…”

Section: Discussionmentioning

confidence: 99%

Relation between urinary bicarbonate concentration and carbon dioxide tension in patients with proximal or distal renal tubular acidosis.

Ueda

1981

Tohoku J. Exp. Med.

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“…Above a threshold of 24 mmol/l, the kidney would excrete bicarbonate proportionally to the filtration rate. 1 In this particular case, however, prerenal failure and volume depletion led to a reduced filtered load of bicarbonate. Additional mechanisms are likely to have also contributed.…”

Section: Discussionmentioning

confidence: 80%