Bicuspid Aortic Valve

Tokmaji, George; Berto, José Carlos; R., Dave; de, Bas A.J.M.

doi:10.5772/55325

Cited by 1 publication

(2 citation statements)

References 110 publications

(162 reference statements)

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“…Genetic changes in microRNAs are believed to be associated with aortic dilation in bicuspid valves, although the pathogenesis of the aortopathy is not completely understood [12]. Interestingly, is has been shown that aneurysmal aortic dilatation in the bicuspid valve is not necessarily connected with valve dysfunction, as dilation can exist in the absence of aortic stenosis or insufficiency [10]. In our case, the bicuspid valve was shown to be by the invasive and non-invasive tests we performed.…”

Section: Discussionmentioning

confidence: 54%

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Management of Late-Presenting Congenital Combined Heart Defect – Bicuspid Aortic Valve and Ventricular Septal Aneurysm

2020

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Objective:Rare disease Background:Bicuspid aortic valve is the most common congenital heart malformation, encountered in 1-2% of the population, while interventricular septal defect and patent ductus arteriosus are the most common congenital malformations associated with bicuspid aortic valve. Although bicuspid valve can have no clinical manifestation, patients with bicuspid valve are prone to develop vascular abnormalities. Aortic dilatation is the most common of these abnormalities, which in turn can lead to serious complications and often requires surgical treatment. Coexistence of bicuspid aortic valve and interventricular septal aneurysm is very extremely rare. Case Report:We present a very rare case of a female patient with combined congenital cardiac pathology. The patient was asymptomatic until age 68 years, and presented with nonspecific persistent cough. The diagnostic work-up for the unexplained cough showed normal function of the bicuspid valve and an ascending aorta aneurysm accompanied with interventricular septal aneurysm. The patient was referred for surgery. The diagnostic workup and the decision for surgical treatment were thoroughly discussed to determine whether it was a true or a false aneurysm. Conclusions:The presented case is an example of late diagnosis of a congenital cardiac defect. The silent evolution and the scarce clinical presentation led to incidental discovery of the pathology, which was fully assessed only by computed tomography. Although echocardiography is essential for discovering heart defects, non-invasive imaging techniques are required for detailed morphological assessment and for planning optimal surgical treatment.

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Section: Discussionmentioning

confidence: 54%

“…Aneurysmal dilatation of the aorta is the most common complication of bicuspid valve. The reported incidence of ascending aorta aneurysmal dilatation in patients with bicuspid valve varies between 20% and 84% [10,11]. The mechanisms leading to aortic dilatation are not clearly understood.…”

Section: Discussionmentioning

confidence: 99%