Bicyclic 6-6 Systems: Other Four Heteroatoms 2:2

Herbert, John M.

doi:10.1016/b978-008044992-0.00919-6

Comprehensive Heterocyclic Chemistry III 2008

DOI: 10.1016/b978-008044992-0.00919-6

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Bicyclic 6-6 Systems: Other Four Heteroatoms 2:2

John M. Herbert¹

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2022

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Cited by 2 publications

References 312 publications

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Benzo[c][1,2]thiazine‐Based Analogs in the Inverse Electron Demand [4+2] Hetero Diels‐Alder Reaction with Glycals: Access to Tetracyclic Fused Galactose and Fucose Derivatives

et al. 2022

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In memory of Prof. Giovanni Romeo, who gave a fundamental contribution to the field of cycloaddition reactionsThe synthesis and reactivity in an [4 + 2] inverse electron demand hetero Diels-Alder reaction (ihDA) of an original class of electronpoor heterodienes, the N-substituted-1H-benzo [c][1,2]thiazin-4one-2,2-dioxides, are described. These are highly reactive electrophiles that allow easy access to unprecedented benzo-thiazine glyco-fused derivatives in a remarkably selective way, even when using acetylated glycals, previously unexplored within this version of ihDA. DFT calculations support the experimental data, and moreover show that acetylated dienophiles can easily react making cycloadditions feasible.

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Benzo[c][1,2]thiazine‐Based Analogs in the Inverse Electron Demand [4+2] Hetero Diels‐Alder Reaction with Glycals: Access to Tetracyclic Fused Galactose and Fucose Derivatives

et al. 2022

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Multiple and One-Pot Synthetic Strategies for Pyrimido-Thiazine and their Derivatives

Chittilappilly

Chandran

Krishnakumar

2022

COC

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In the present era the use of fused heterocyclic compounds has been showing a considerable value in the development and designing of new drugs. Article flow through the synthetic strategies highlight on the application of metal-free, visible light mediated catalysis for the fusion of six-membered heterocyclic scaffolds containing nitrogen and sulfur heteroatoms. The power stratagem for the synthesis of diverse fused heterocyclic compounds is the sequencing of multicomponent reactions and subsequent cyclization reactions. The heterocyclic compounds containing Nitrogen and Sulphur atoms exhibit unique properties and are used as potential reactive materials in pharmacokinetic systems. These compounds can also be synthesized considering the high yield, low waste and green synthesis. The main aim of this review is to give an outlook about the synthetic feasibility of fused heterocyclic system and to development an innovative heterocyclic synthetic scheme that allow for different bond forming strategies which are having a significant impact in the pharmaceutical industry, especially the pyrimido-thiazine derivatives in the future synthetic heterocyclic chemistry. The future of Heterocyclic chemistry is development of robust synthetic routes which can generate bulk quantity of desired products and accelerate the drug development process.

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Bicyclic 6-6 Systems: Other Four Heteroatoms 2:2

Cited by 2 publications

References 312 publications

Benzo[c][1,2]thiazine‐Based Analogs in the Inverse Electron Demand [4+2] Hetero Diels‐Alder Reaction with Glycals: Access to Tetracyclic Fused Galactose and Fucose Derivatives

Benzo[c][1,2]thiazine‐Based Analogs in the Inverse Electron Demand [4+2] Hetero Diels‐Alder Reaction with Glycals: Access to Tetracyclic Fused Galactose and Fucose Derivatives

Multiple and One-Pot Synthetic Strategies for Pyrimido-Thiazine and their Derivatives

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