Bicyclic Systems with Two Ring Junction Nitrogen Atoms

Amine-functionalized MCM-41 as an efficient catalyst for the synthesis of sulfur/dinitrogen-fused heterocycles via [3+3] cycloaddition in water

“…Dinitrogen-fused heterocycles are common motifs in bioactive compounds and have been widely investigated in applications such as herbicides and pesticides. 1–6 For example, compound A , a 6-member cycloalkyl pyrazolidinone, showed good inhibitory activity against MTHFD2 dehydrogenation (Scheme 1a). 7 Compound B , with 6-member N-heterocycle ring fused pyrazolidinones, was also found to have good antibacterial activity (Scheme 1a).…”

Solvent-free 1,3-dipolar cycloaddition of azomethine imines with terminal alkynes promoted by calcium fluoride under the ball milling condition

“…In particular, N,N-bicyclic pyrazolidinone derivatives show important bioactivities and have been widely investigated as anti-inflammatory drugs, pesticides, herbicides, and β-lactam mimics towards new antibiotics [4][5][6][7][8][9] . Several routes have been developed for the synthesis of pyrazolidin-3-ones and their N,N-bicyclic derivatives [10,11] .…”