Bicyclol alleviates obesity-induced renal injury by inhibiting JNK and NF-κB-mediated inflammation

Zhang, Lingxi; Wang, Jiong; Xu, Tingxin; Luo, Yue; Cai, Zhaohong; Jiang, Yongsheng; Jin, Tianyang; Bao, Hongdan; Wang, Yi

doi:10.1016/j.intimp.2024.111609

Cited by 2 publications

(2 citation statements)

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“…Obesity is one of the most significant health problems worldwide today, and its prevalence, along with related illnesses, is continually rising [ 1 ]. This chronic condition is characterized by excessive body fat accumulation and is associated with a shortened life expectancy.…”

Section: Introductionmentioning

confidence: 99%

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Bioactive Peptides from Meretrix lusoria Enzymatic Hydrolysate as a Potential Treatment for Obesity in db/db Mice

Chilakala,

Moon,

Jung

et al. 2024

Nutrients

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Obesity is acknowledged as a significant risk factor for cardiovascular disease, often accompanied by increased inflammation and diabetes. Bioactive peptides derived from marine animal proteins show promise as safe and effective anti-obesity agents by regulating adipocyte differentiation through the AMPK signaling pathway. Therefore, this study aims to investigate the anti-obesity and anti-diabetic effects of bioactive compounds derived from a Meretrix lusoria Protamex enzymatic hydrolysate (MLP) fraction (≤1 kDa) through a 6-week treatment (150 mg/kg or 300 mg/kg, administered once daily) in leptin receptor-deficient db/db mice. The MLP treatment significantly decreased the body weight, serum total cholesterol, triglycerides, and LDL-cholesterol levels while also exhibiting a beneficial effect on hepatic and serum marker parameters in db/db mice. A histological analysis revealed a reduction in hepatic steatosis and epididymal fat following MLP treatment. Furthermore, poor glucose tolerance was improved, and hepatic antioxidant enzyme activities were elevated in MLP-treated mice compared to db/db control mice. Western blot analysis showed an increased expression of the AMPK protein after MLP treatment. In addition, the expression of lipogenic genes decreased in db/db mice. These findings indicate that bioactive peptides, which are known to regulate blood glucose levels, lipid metabolism, and adipogenesis, could be beneficial functional food additives and pharmaceuticals.

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Section: Introductionmentioning

confidence: 99%

“…1 Acetyl-CoA carboxylase (ACC), glucose 6-phosphatase (G6Pase), liver glycogen phosphorylase (LGP), glycogen synthase (GS), phosphoenolpyruvate carboxykinase (PEPCK), fatty acid synthase (FAS), carnitine palmitoyltransferase (CPT), pyruvate dehydrogenase kinase (PDK), and stearoyl-CoA desaturase (SCD).…”

mentioning

confidence: 99%