We report on a possible cloud-cloud collision in the DR 21 region, which we found through molecular observations with the Nobeyama 45-m telescope. We mapped an area of ∼ 8 × 12 around the region with twenty molecular lines including the 12 CO(J = 1−0) and 13 CO(J = 1−0) emission lines, and sixteen of them were significantly detected. Based on the 12 CO and 13 CO data, we found five distinct velocity components in the observed region, and we call molecular gas associated with these components "−42","−22", "−3", "9", and "17" km s −1 clouds taking after their typical radial velocities. The −3 km s −1 cloud is the main filamentary cloud (∼ 31,000 M ) associated with young massive stars such as DR21 and DR21(OH), and the 9 km s −1 cloud is a smaller cloud (∼ 3, 400 M ) which may be an extension of the W75 region in the north. The other clouds are much smaller. We found a clear anticorrelation in the distributions of the −3 and 9 km s −1 clouds, and detected faint 12 CO emission having intermediate velocities bridging the two clouds at their intersection. These facts strongly indicate that the two clouds are colliding against each other. In addition, we found that DR21 and DR21(OH) are located in the periphery of the densest part of the 9 km s −1 cloud, which is consistent with results of recent numerical simulations of cloud-cloud collisions. We therefore suggest that the −3 and 9 km s −1 clouds are colliding, and that the collision induced the massive star formation in the DR21 cloud. The interaction of the −3 and 9 km s −1 clouds was previously suggested by Dickel, Dickel, and Wilson (1978), and our results strongly support their hypothesis of the interaction.