Bidirectional Associations Between Clinically Relevant Depression or Anxiety and COPD

Atlantis, Evan; Fahey, Paul; Cochrane, Belinda; Smith, Sheree

doi:10.1378/chest.12-1911

Cited by 299 publications

(250 citation statements)

References 38 publications

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“…The co-presence of depression and anxiety in patients with COPD increases the mortality rate (of 83% according to some authors) [1,13]. The incidence of depression/anxiety increases with COPD worsening [2,13]. Even in this case, the exact mechanisms leading to this correlation are unclear.…”

Section: Depression Anxiety and Chronic Pain In Copdmentioning

confidence: 99%

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Depression, anxiety and chronic pain in patients with chronic obstructive pulmonary disease: the influence of breath

Bordoni

Marelli²,

Bruno

et al. 2017

Monaldi Arch Chest Dis

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Chronic obstructive pulmonary disease (COPD) is a major public health problems, causing significant mortality and morbidity in the world. It is a complex and progressive disease, characterized by chronic inflammation and dysfunction of the respiratory airways. The article reviews the available information on the potential role of the diaphragm in this disease. The purpose is to identify a potential correlation between symptoms such as depression, anxiety and chronic pain, frequently observed in COPD, with the activity of the diaphragm. The morphology and metabolism of the diaphragm are usually modified in the presence of COPD: a correlation between this symptoms and a pathological adaptation of breathing can be hypothesized. The management of these conditions should always be multidisciplinary, in order to have a global vision of the patient.

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Section: Depression Anxiety and Chronic Pain In Copdmentioning

confidence: 99%

“…Anyway, there are not enough data exhaustively explaining this correlation [12]. The co-presence of depression and anxiety in patients with COPD increases the mortality rate (of 83% according to some authors) [1,13]. The incidence of depression/anxiety increases with COPD worsening [2,13].…”

Section: Depression Anxiety and Chronic Pain In Copdmentioning

confidence: 99%

Depression, anxiety and chronic pain in patients with chronic obstructive pulmonary disease: the influence of breath

Bordoni

Marelli²,

Bruno

et al. 2017

Monaldi Arch Chest Dis

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show abstract

“…Patients with COPD and depression report increased dyspnea, worse quality of life, and decreased treatment adherence, thus making it less likely that proven medical therapies or behavioral interventions such as tobacco cessation or pulmonary rehabilitation would be effective or their benefits maintained (37,38). Although the underlying mechanistic links remain uncertain, the association between depression and COPD hospitalization is likely bidirectional, wherein depression worsens COPD-related morbidity and mortality, and COPD increases the risk of depression (39,40).…”

Section: Original Researchmentioning

confidence: 99%

Depression Is Associated with Readmission for Acute Exacerbation of Chronic Obstructive Pulmonary Disease

et al. 2016

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Rationale: Hospitalization for acute exacerbation of chronic obstructive pulmonary disease (COPD) is associated with significant morbidity and health care costs, and hospitals in the United States are now penalized by the Centers for Medicare and Medicaid Services for excessive readmissions. Identifying patients at risk of readmission is important, but modifiable risk factors have not been clearly established, and the potential contributing role of psychological disease has not been examined adequately. We hypothesized that depression and anxiety would increase the risk of both short-and long-term readmissions for acute exacerbation of COPD.Objectives: To characterize the associations between depression and anxiety and COPD readmission risk. Methods:We examined the medical records for all patients with a primary diagnosis of acute exacerbation of COPD by International Classification of Diseases, Ninth Revision codes admitted to the University of Alabama at Birmingham Hospital between November 2010 and October 2012. Those who did not meet the standardized study criteria for acute exacerbation of COPD and those with other respiratory illnesses as the primary diagnosis were excluded. Comorbidities were recorded on the basis of physician documentation of the diagnosis and/or the use of medications in the electronic medical record. Multivariable regression analyses identified factors associated with readmission for acute exacerbation of COPD at 1 year and within 30 and 90 days.Measurements and Main Results: Four hundred twenty-two patients were included, with 132 readmitted in 1 year. Mean age was 64.8 6 11.7 years, and mean percent predicted FEV 1 was 48.1 6 18.7%. On univariate analysis, readmitted patients had lower percent predicted FEV 1 (44.9 6 17.3% vs. 50.2 6 19.4%; P = 0.05) and a higher frequency of depression (47.7% vs. 23.4%; P , 0.001). On multivariable analysis, 1-year readmission was independently associated with depression (adjusted odds ratio [OR], 2.67; 95% confidence interval [CI], 1.59-4.47) and in-hospital tobacco cessation counseling (adjusted OR, 0.34; 95% CI, 0.18-0.66). Depression also predicted readmission at 30 days (adjusted OR, 3.83; 95% CI, 1.84-7.96) and 90 days (adjusted OR, 2.47; 95% CI, 1.34-4.55).Conclusions: Depression is an independent risk factor for both short-and long-term readmissions for acute exacerbation of COPD and may represent a modifiable risk factor. In-hospital tobacco cessation counseling was also associated with reduced 1-year readmission.

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“…Depression is associated with increased frequency of hospital admissions, prolonged length of stay, increased number of consultations, low compliance with medical treatment and premature death 7,8 . Patients with COPD have a higher prevalence of depression and anxiety than the general population 9,10 and COPD patients have relative risk of 1.69 of developing depression 11 .…”

Section: Introductionmentioning

confidence: 99%

Exercise alleviates depression related systemic inflammation in chronic obstructive pulmonary disease patients

2017

Afr H. Sci.

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Background: Depression is a highly prevalent co-morbidity in Chronic Obstructive Pulmonary Disease (COPD) which was shown to be associated with a worse course of disease, including reduced quality of life and increased symptoms burden, healthcare use, and even mortality. It has been speculated that systemic inflammation may play a role in the presence of depression. Currently, physical activity is an important lifestyle factor that has the potential to modify inflammatory cytokines and depression, however our understanding of how to use exercise effectively in COPD patients to alleviate depression related systemic inflammation is incomplete and has prompted our interest to identify the type and intensities of effective exercise. Objective: The aim of this study was to measure the changes in depression related systemic inflammation of aerobic exercise training in COPD patients in Jeddah area. Material and methods: Eighty patients with moderate severity of COPD participated in this study and were divided into two groups; the first group received aerobic exercise, whereas the second group received no exercise training for 12 weeks. Results:The mean values of tumor necrosis factor-alpha (TNF-α), interleukin-4 (IL-4), interleukin-6 (IL-6), C-reactive protein (CRP) and Beck Depression Inventory (BDI) scores were significantly decreased in in group (A) after treatments, but the changes in group (B) were not significant .Also, there were significant differences between mean levels of the investigated parameters in group (A) and group (B) at the end of the study. Conclusion: Aerobic exercise is an effective treatment policy to improve depression related to systemic inflammation in patients with chronic obstructive pulmonary disease.

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Bidirectional Associations Between Clinically Relevant Depression or Anxiety and COPD

Cited by 299 publications

References 38 publications

Depression, anxiety and chronic pain in patients with chronic obstructive pulmonary disease: the influence of breath

Depression, anxiety and chronic pain in patients with chronic obstructive pulmonary disease: the influence of breath

Depression Is Associated with Readmission for Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Exercise alleviates depression related systemic inflammation in chronic obstructive pulmonary disease patients

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