Bidirectional Brain‐gut‐microbiota Axis in increased intestinal permeability induced by central nervous system injury

Li, Xiaojin; You, Xin-Yu; Wang, Congying; Li, Xueli; Sheng, Yuanyuan; Zhuang, Pengwei; Zhang, Yan‐jun

doi:10.1111/cns.13401

Cited by 71 publications

(57 citation statements)

References 68 publications

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“…Moreover, it has been hypothesized that gut dysbiosis may be a cause of increased levels of oxidative stress in the central nervous system [85]. But also vice versa, central nervous system injuries may cause changes in the gut environment, and trigger alterations of gut microbiome [86]. In this context, it has been demonstrated that brain injury may induce changes in the gut microbiome composition via altered autonomic balance [24].…”

Section: Discussionmentioning

confidence: 99%

Retinitis Pigmentosa Is Associated With Shifts in The Gut Microbiome

Kutsyr

Maestre‐Carballa

Lluesma-Gomez

et al. 2020

Preprint

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Background: The gut microbiome is known to influence the pathogenesis and progression of neurodegenerative diseases. However, there has been relatively little focus upon the implications of the gut microbiome in retinal diseases such as retinitis pigmentosa (RP) that leads to photoreceptor degeneration and is the main worldwide cause of complete blindness in adulthood. Here, we investigated changes in gut microbiome composition linked to RP, by assessing both retinal degeneration and gut microbiome in the rd10 mouse model of RP as compared to control C57BL/6J mice.Results: In rd10 mice, retinal responsiveness to flashlight stimuli was deteriorated with respect to observed in age-matched control mice, with decreased amplitudes in the a- and b-wave responses of the electroretinogram and concomitant reduction of the visual acuity. This functional decline in dystrophic animals was accompanied by photoreceptor loss, evidenced by decreased outer nuclear layer thickness, and morphologic anomalies in photoreceptor cells. Changes in retinal neurons were paralleled to induction of reactive gliosis in retina, with increased microglial cell numbers and higher Müller cell reactivity in rd10 mice. Furthermore, 16S rRNA gene amplicon sequencing data showed a microbial gut dysbiosis with differences in alpha and beta diversity at the genera, species and amplicon sequence variants (ASV) levels between dystrophic and control mice. A taxonomic partitioning of ASV was observed since unique ASVs present in only one group had a cumulative relative microbial abundance between 17.6% (rd10 mice) and 26.7% (C57BL/6J mice). Remarkably, four fairly common ASV in healthy gut microbiome belonging to -Rikenella spp., Muribaculaceace spp., Prevotellaceae UCG-001 spp., and Bacilli spp.- were absent in the gut microbiome of retinal disease mice, while Bacteroides caecimuris was significantly enriched in mice with retinitis pigmentosa. Conclusions: Our results indicate that retinal degenerative changes in retinitis pigmentosa are linked to relevant gut microbiome changes. The findings suggest that microbiome shifting could be considered as potential biomarker and therapeutic target for retinal degenerative diseases.

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Section: Discussionmentioning

confidence: 99%

Retinitis Pigmentosa Is Associated With Shifts in The Gut Microbiome

Kutsyr

Maestre‐Carballa

Lluesma-Gomez

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Moreover, it has been hypothesized that gut dysbiosis may be a cause of increased levels of oxidative stress in the central nervous system 79 . But also vice versa, central nervous system injuries may cause changes in the gut environment, and trigger alterations of gut microbiome 80 . In this context, it has been demonstrated that brain injury may induce changes in the gut microbiome composition via altered autonomic balance 24 .…”

Section: Discussionmentioning

confidence: 99%

Retinitis Pigmentosa is Associated With Shifts in The Gut Microbiome

Kutsyr

Maestre‐Carballa

Lluesma-Gomez

et al. 2020

Preprint

View full text Add to dashboard Cite

The gut microbiome is known to influence the pathogenesis and progression of neurodegenerative diseases. However, there has been relatively little focus upon the implications of the gut microbiome in retinal diseases such as retinitis pigmentosa (RP). Here, we investigated changes in gut microbiome composition linked to RP, by assessing both retinal degeneration and gut microbiome in the rd10 mouse model of RP as compared to control C57BL/6J mice. In rd10 mice, retinal responsiveness to flashlight stimuli and visual acuity were deteriorated with respect to observed in age-matched control mice. This functional decline in dystrophic animals was accompanied by photoreceptor loss, morphologic anomalies in photoreceptor cells and retinal reactive gliosis. Furthermore, 16S rRNA gene amplicon sequencing data showed a microbial gut dysbiosis with differences in alpha and beta diversity at the genera, species and amplicon sequence variants (ASV) levels between dystrophic and control mice. Remarkably, four fairly common ASV in healthy gut microbiome belonging to Rikenella spp., Muribaculaceace spp., Prevotellaceae UCG-001 spp., and Bacilli spp. were absent in the gut microbiome of retinal disease mice, while Bacteroides caecimuris was significantly enriched in mice with RP. The results indicate that retinal degenerative changes in RP are linked to relevant gut microbiome changes. The findings suggest that microbiome shifting could be considered as potential biomarker and therapeutic target for retinal degenerative diseases.

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“…Reversely, in a global study (COPDMAP study) scientists reported that respiratory infections impact upon the intestinal microbiome mediated by Th17 cells ( Wang and on behalf of COPDMAP study, 2017 ). Recently, it is shown that this bidirectional dialogue is not only of concern to the bacterial potential but it is related to fungal one as well ( Li X. et al., 2020 ). The role of resident intestinal macrophages in airway inflammation and fungal dysbiosis is highlighted ( Leonardi et al., 2018 ).…”

Section: The Gut–lung Microbiome Axismentioning

confidence: 99%

Unraveling the Interconnection Patterns Across Lung Microbiome, Respiratory Diseases, and COVID-19

Stavropoulou

Kantartzi

Tsigalou

et al. 2021

Front. Cell. Infect. Microbiol.

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Albeit the lungs were thought to be sterile, recent scientific data reported a microbial microbiota in the lungs of healthy individuals. Apparently, new developments in technological approachesincluding genome sequencing methodologies contributed in the identification of the microbiota and shed light on the role of the gut and lung microbiomes in the development of respiratory diseases. Moreover, knowledge of the human microbiome in health may act as a tool for evaluating characteristic shifts in the case of disease. This review paper discusses the development of respiratory disease linked to the intestinal dysbiosis which influences the lung immunity and microbiome. The gastrointestinal–lung dialogue provides interesting aspects in the pathogenesis of the respiratory diseases. Lastly, we were further interested on the role of this interconnection in the progression and physiopathology of newly emergedCOVID-19.

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Bidirectional Brain‐gut‐microbiota Axis in increased intestinal permeability induced by central nervous system injury

Cited by 71 publications

References 68 publications

Retinitis Pigmentosa Is Associated With Shifts in The Gut Microbiome

Retinitis Pigmentosa Is Associated With Shifts in The Gut Microbiome

Retinitis Pigmentosa is Associated With Shifts in The Gut Microbiome

Unraveling the Interconnection Patterns Across Lung Microbiome, Respiratory Diseases, and COVID-19

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