Bidirectional Coupling between Ryanodine Receptors and Ca2+ Release-activated Ca2+ (CRAC) Channel Machinery Sustains Store-operated Ca2+ Entry in Human T Lymphocytes

Thakur, Pratima; Dadsetan, Sepehr; Fomina, Alla F.

doi:10.1074/jbc.m112.398974

Cited by 37 publications

(54 citation statements)

References 77 publications

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“…With human T‐lymphocytes, a SOC(E) mechanism has been described that involves RyRs and similar coupling (Thakur et al. ), just as we found with Paramecium . Here, alveolar sacs contain Pt CRC‐IV channels (Fig.…”

Section: Focusing Still More On Details Specific For Parameciumsupporting

confidence: 83%

Calcium Regulation in the Protozoan Model, Paramecium tetraurelia

Plattner

2013

J Eukaryotic Microbiology

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Early in eukaryotic evolution, the cell has evolved a considerable inventory of proteins engaged in the regulation of intracellular Ca(2+) concentrations, not only to avoid toxic effects but beyond that to exploit the signaling capacity of Ca(2+) by small changes in local concentration. Among protozoa, the ciliate Paramecium may now be one of the best analyzed models. Ciliary activity and exo-/endocytosis are governed by Ca(2+) , the latter by Ca(2+) mobilization from alveolar sacs and a superimposed store-operated Ca(2+) -influx. Paramecium cells possess plasma membrane- and endoplasmic reticulum-resident Ca(2+) -ATPases/pumps (PMCA, SERCA), a variety of Ca(2+) influx channels, including mechanosensitive and voltage-dependent channels in the plasma membrane, furthermore a plethora of Ca(2+) -release channels (CRC) of the inositol 1,4,5-trisphosphate and ryanodine receptor type in different compartments, notably the contractile vacuole complex and the alveolar sacs, as well as in vesicles participating in vesicular trafficking. Additional types of CRC probably also occur but they have not been identified at a molecular level as yet, as is the equivalent of synaptotagmin as a Ca(2+) sensor for exocytosis. Among established targets and sensors of Ca(2+) in Paramecium are calmodulin, calcineurin, as well as Ca(2+) /calmodulin-dependent protein kinases, all with multiple functions. Thus, basic elements of Ca(2+) signaling are available for Paramecium.

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Section: Focusing Still More On Details Specific For Parameciumsupporting

confidence: 83%

Calcium Regulation in the Protozoan Model, Paramecium tetraurelia

Plattner

2013

J Eukaryotic Microbiology

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“…Induction by oxidized-LDL increased the endothelial calcium levels and also calcium-mediated production of monocyte chemoattractant protein-1 (MCP-1), [45] which is integral to recruiting inflammatory monocytes into the vascular walls [47]. Furthermore, RYRs are also involved in T-lymphocyte cell activation and expansion through calcium regulation [48, 49]. On the other hand, FK506 binding protein 1A, 12kDa (FKBP12) binds to RYR3 [50] and regulates calciumrelease by stabilizing the closed state of the receptor whereas transforming growth factor beta (TGF-beta) [51] regulates the expression of the RYRs and thereby calcium homeostasis.…”

Section: Discussionmentioning

confidence: 99%

RYR3 gene variants in subclinical atherosclerosis among HIV-infected women in the Women's Interagency HIV Study (WIHS)

Shendre¹,

Irvin²,

Aouizerat³

et al. 2014

Atherosclerosis

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Background Single nucleotide polymorphisms (SNPs) in the Ryanodine receptor 3 (RYR3) gene are associated with common carotid intima media thickness (CCA cIMT) in HIV-infected men. We evaluated SNPs in the RYR3 gene among HIV-infected women participating in Women’s Interagency HIV Study (WIHS). Methods CCA cIMT was measured using B-mode ultrasound and the 838 SNPs in the RYR3 gene region were genotyped using the Illumina HumanOmni2.5-quad beadchip. The CCA cIMT genetic association was assessed using linear regression analyses among 1213 women and also separately among White (n=139), Black (n=720) and Hispanic (n=354) women after adjusting for confounders. A summary measure of pooled association was estimated using a meta-analytic approach by combining the effect estimates from the three races. Haploblocks were inferred using Gabriel’s method and haplotype association analyses were conducted among the three races separately. Results SNP rs62012610 was associated with CCA cIMT among the Hispanics (p=4.41× 10−5), rs11856930 among Whites (p=5.62× 10−4), and rs2572204 among Blacks (p=2.45× 10−3). Meta-analysis revealed several associations of SNPs in the same direction and of similar magnitude, particularly among Blacks and Hispanics. Additionally, several haplotypes within three haploblocks containing SNPs previously related with CCA cIMT were also associated in Whites and Hispanics. Discussion Consistent with previous research among HIV-infected men, SNPs within the RYR3 region were associated with subclinical atherosclerosis among HIV-infected women. Allelic heterogeneity observed across the three races suggests that the contribution of the RYR3 gene to CCA cIMT is complex, and warrants future studies to better understand regional SNP function.

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“…The IP 3 R mediated depletion of ER is not the sole mechanism responsible for ER emptying, and in fact, despite the positive feedback between IP 3 R and CRAC channels, IP 3 levels are known to decrease within 10 min post activation. Ryanodine receptors (RyRs) in the ER membrane may account for the sustained Ca 2+ release over long period because the second messenger that acts of RyRs, cyclic adenosine diphosphoribose, 15 can be detected for over 60 min 16 . Akin to IP 3 Rs, there are multiple subtypes of RyRs, 17 , 18 and they can be phosphorylated by Fyn to enhance Ca 2+ release 19 .…”

Section: The Ups and Downs Of Calcium Signalling: Mechanisms Of Calcimentioning

confidence: 99%

The functional contribution of calcium ion flux heterogeneity in T cells

2015

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The role of intracellular calcium ion oscillations in T-cell physiology is being increasingly appreciated by studies that describe how unique temporal and spatial calcium ion signatures can control different signalling pathways. Within this review, we provide detailed mechanisms of calcium ion oscillations, and emphasise the pivotal role that calcium signalling plays in directing crucial events pertaining to T-cell functionality. We also describe methods of calcium ion quantification, and take the opportunity to discuss how a deeper understanding of calcium signalling combined with new detection and quantification methodologies can be used to better design immunotherapies targeting T-cell responses.

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Bidirectional Coupling between Ryanodine Receptors and Ca2+ Release-activated Ca2+ (CRAC) Channel Machinery Sustains Store-operated Ca2+ Entry in Human T Lymphocytes

Cited by 37 publications

References 77 publications

Calcium Regulation in the Protozoan Model, Paramecium tetraurelia

Calcium Regulation in the Protozoan Model, Paramecium tetraurelia

RYR3 gene variants in subclinical atherosclerosis among HIV-infected women in the Women's Interagency HIV Study (WIHS)

The functional contribution of calcium ion flux heterogeneity in T cells

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