Bidirectional crosstalk between dysbiotic gut microbiota and systemic lupus erythematosus: What is new in therapeutic approaches?

Yaigoub, Hasnaa; Fath, Nada; Tirichen, Hasna; Wu, Changxin; Li, Rongshan; Li, Yafeng

doi:10.1016/j.clim.2022.109109

Cited by 6 publications

(8 citation statements)

References 107 publications

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“…It is generally accepted that the human gut flora consists of about 30 genera and 500 species of bacteria, the microbiota, and that these intestinal players work together to maintain homeostasis in the human gastrointestinal tract (Ling et al, 2022), ensuring the integrity of the epithelial barrier function of the gut and the normal function of various immune cells. Our group has found that dysbiosis of the intestinal flora is associated with many autoimmune diseases, such as primary Sjögren's syndrome (Xin et al, 2022), systemic lupus erythematosus (Yaigoub et al, 2022) and Takayasu arteritis (TA) (Fan et al, 2022). But in this study, our analysis found significantly lower intestinal bacterial abundance and species richness in children with IgAV, KD and IgAN groups than in healthy children, but also a relatively increased number of genera in the different diseases.…”

Section: A B Figurecontrasting

confidence: 65%

Landscape of intestinal microbiota in patients with IgA nephropathy, IgA vasculitis and Kawasaki disease

Fan

Song

et al. 2022

Front. Cell. Infect. Microbiol.

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ObjectiveTo explore the common differential flora of IgAN, Kawasaki disease and IgA vasculitis by screening and analyzing the differential intestinal flora between the three disease groups of IgAN, Kawasaki disease and IgA vasculitis and their healthy controls.MethodsPapers on 16srRNA sequencing-related intestinal flora of IgAN, Kawasaki disease and IgA vasculitis were searched in databases, the literature was systematically collated and analysed, the original data was download from the relevant databases, and then the operational taxonomic unit and species classification analysis were performed. Besides, Alpha diversity analysis and Beta diversity analysis were performed to screen for IgAN, Kawasaki disease and I1gA vasculitis groups and finally compare the common intestinal differential flora among the three groups.ResultsAmong the common differential flora screened, Lachnospiracea_incertae_sedis was lower in both the IgAN and Kawasaki disease groups than in the respective healthy controls; Coprococcus was low in the IgAN group but high in the IgA vasculitis group. Fusicatenibacter was lower in both the Kawasaki disease and IgA vasculitis groups than in their respective healthy controls, and Intestinibacter was low in the Kawasaki disease group, but its expression was high in the IgA vasculitis group.ConclusionThe dysbiosis of the intestinal flora in the three groups of patients with IgAN, Kawasaki disease and IgA vasculitis, its effect on the immunity of the organism and its role in the development of each disease group remain unclear, and the presence of their common differential flora may further provide new ideas for the association of the pathogenesis of the three diseases.

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Section: A B Figurecontrasting

confidence: 65%

Landscape of intestinal microbiota in patients with IgA nephropathy, IgA vasculitis and Kawasaki disease

Fan

Song

et al. 2022

Front. Cell. Infect. Microbiol.

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“…Nevertheless, the pro‐inflammatory role of CD14 appears to outweigh its anti‐inflammatory role in SLE pathogenesis because of the fact that dysbiosis in lupus patients leads to an increase of gut permeability followed by recognition of pathogenic bacterial LPS by tissue macrophages and causes tissue damage. Moreover, TLR4‐LPS interaction activates monocytes which then induces CD14 release and SLE development 55 . CD80 (B7‐1) is a surface molecule on antigen presenting cells (APCs) that provides costimulatory signals for T lymphocytes activation through binding to CD28 or CTLA‐4.…”

Section: Discussionmentioning

confidence: 99%

Tolerogenic probiotics Lactobacillus delbrueckii and Lactobacillus rhamnosus promote anti‐inflammatory profile of macrophages‐derived monocytes of newly diagnosed patients with systemic lupus erythematosus

Javanmardi,

Mahmoudi,

Rafatpanah

et al. 2024

Cell Biochemistry & Function

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Systemic lupus erythematosus (SLE) is known as an autoimmune disorder that is characterized by the breakdown of self‐tolerance, resulting in disease onset and progression. Macrophages have been implicated as a factor in the development of SLE through faulty phagocytosis of dead cells or an imbalanced M1/M2 ratio. The study aimed to investigate the immunomodulatory effects of Lactobacillus delbrueckii and Lactobacillus rhamnosus on M1 and M2 macrophages in new case lupus patients. For this purpose, blood monocytes were collected from lupus patients and healthy people and were cultured for 5 days to produce macrophages. For 48 h, the macrophages were then cocultured with either probiotics or lipopolysaccharides (LPS). Flow cytometry and real‐time polymerase chain reaction were then used to analyze the expression of cluster of differentiation (CD) 14, CD80, and human leukocyte antigen – DR (HLADR) markers, as well as cytokine expression (interleukin [IL]1‐β, IL‐12, tumor necrosis factor α [TNF‐α], IL‐10, and transforming growth factor beta [TGF‐β]). The results indicated three distinct macrophage populations, M0, M1, and M2. In both control and patient‐derived macrophage‐derived monocytes (MDMs), the probiotic groups showed a decrease in CD14, CD80, and HLADR expression compared to the LPS group. This decrease was particularly evident in M0 and M2 macrophages from lupus patients and M1 macrophages from healthy subjects. In addition, the probiotic groups showed increased levels of IL‐10 and TGF‐β and decreased levels of IL‐12, IL1‐β, and TNF‐α in MDMs from both healthy and lupus subjects compared to the LPS groups. Although there was a higher expression of pro‐inflammatory cytokines in lupus patients, there was a higher expression of anti‐inflammatory cytokines in healthy subjects. In general, L. delbrueckii and L. rhamnosus could induce anti‐inflammatory effects on MDMs from both healthy and lupus subjects.

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“…As described in previous sessions, gut microbe changes are seen in all autoimmune diseases and gut microbe restoration is associated with inflammation reduction [ 70 , 71 , 72 ]. Direct regulation of gut microbiota may be achieved with probiotics and fecal microbiota transplantation.…”

Section: Potential Microbiome Therapeutics For Ctd-ild and Vasculitismentioning

confidence: 98%

“…Vitamin D deficiency is frequent in CTD-ILDs [ 15 ], other ILDs such as IPF [ 14 ] and autoimmune diseases, such as SLE [ 70 ]. Vitamin D supplementation can restore the gut intestinal barrier integrity, by restoring gut microbiota [ 70 ] and protect from lung fibrosis in animal models [ 14 ].…”

Section: Potential Microbiome Therapeutics For Ctd-ild and Vasculitismentioning

confidence: 99%

The Role of the Microbiome in Connective-Tissue-Associated Interstitial Lung Disease and Pulmonary Vasculitis

et al. 2022

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The microbiome can trigger and maintain immune-mediated diseases and is associated with the severity and prognosis of idiopathic pulmonary fibrosis, which is the prototype of interstitial lung diseases (ILDs). The latter can be a major cause of morbidity and mortality in patients with connective-tissue diseases (CTD). In the present review, we discuss the current evidence regarding microbiome in CTD-ILD and pulmonary vasculitis. In patients with rheumatoid arthritis (RA) the BAL microbiota is significantly less diverse and abundant, compared to healthy controls. These changes are associated with disease severity. In systemic sclerosis (SSc), gastrointestinal (GI)-dysbiosis is associated with ILD. Butyrate acid administration as a means of restoration of GI-microbiota has reduced the degree of lung fibrosis in animal models. Although related studies are scarce for SLE and Sjögren’s syndrome, studies of the gut, oral and ocular microbiome provide insights into the pathogenesis of these diseases. In ANCA-associated vasculitis, disease severity and relapses have been associated with disturbed nasal mucosa microbiota, with immunosuppressive treatment restoring the microbiome changes. The results of these studies suggest however no causal relation. More studies of the lung microbiome in CTD-ILDs are urgently needed, to provide a better understanding of the pathogenesis of these diseases.

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Bidirectional crosstalk between dysbiotic gut microbiota and systemic lupus erythematosus: What is new in therapeutic approaches?

Cited by 6 publications

References 107 publications

Landscape of intestinal microbiota in patients with IgA nephropathy, IgA vasculitis and Kawasaki disease

Landscape of intestinal microbiota in patients with IgA nephropathy, IgA vasculitis and Kawasaki disease

Tolerogenic probiotics Lactobacillus delbrueckii and Lactobacillus rhamnosus promote anti‐inflammatory profile of macrophages‐derived monocytes of newly diagnosed patients with systemic lupus erythematosus

The Role of the Microbiome in Connective-Tissue-Associated Interstitial Lung Disease and Pulmonary Vasculitis

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