Abstract:Summary:The purpose of this study was to demonstrate the value of combined two-dimensional and pulsed Doppler echocardiography (echo) in localizing and recording bidirectional flow in congenital ventricular septal defect. Eight children, aged 8 months to 16 years, with clinical signs of a ventricular septal defect, underwent twodimensional and pulsed Doppler echo study prior to cardiac catheterization. The ventricular septal defect was documented anatomically by two-dimensional echo in all eight patients. Flow… Show more
“…Although VSD is a congenital disease, it can be considered a chronic disease for some adult patients due to imperfect diagnosis and treatment conditions and insufficient attention. The hemodynamic changes caused by the long-term existence of congenital heart malformations also leads to structural changes in the heart to some extent [13]. The results of this study showed that some patients' left ventricular size before treatment was at the high limit of the normal value, which was associated with left-to-right shunt changes in cardiac blood flow caused by VSD.…”
Objective
To investigate the midterm effect of exercise capacity and quality of life (QoL) of adult patients who underwent transthoracic device closure of ventricular septal defects (VSDs) and explore the gap in the quality of life and cardiopulmonary function between those patients and healthy people.
Methods
From January 2010 to January 2015, 58 adult patients who underwent transthoracic device closure of VSD and 60 healthy people matched for age and sex were selected and analyzed. Echocardiography and exercise capacity tests were performed, and the MOS 36-item short-form health survey (SF-36) was used to investigate the changes in QoL.
Results
Fifty-five patients completed the study. At the 1-year and 5-year follow-ups, the patients’ left ventricular end-systolic and end-diastolic diameters were smaller than those preoperatively, but the difference was not statistically significant. In the QoL survey, the patients’ scores after treatment showed a trend of improvement, and the improvement effect was not transient. After VSD closure, the difference in QoL between the patients and the control group was significantly reduced. However, in the exercise capacity test, the patients’ results were still worse than those of the controls.
Conclusion
Transthoracic device closure of VSDs is significant in improving adult patients’ QoL at the midterm follow-up, reflected in their physical and psychological fields. However, they are still unable to achieve normal levels of peak exercise ability. Therefore, further exploration and interventions are worth considering.
“…Although VSD is a congenital disease, it can be considered a chronic disease for some adult patients due to imperfect diagnosis and treatment conditions and insufficient attention. The hemodynamic changes caused by the long-term existence of congenital heart malformations also leads to structural changes in the heart to some extent [13]. The results of this study showed that some patients' left ventricular size before treatment was at the high limit of the normal value, which was associated with left-to-right shunt changes in cardiac blood flow caused by VSD.…”
Objective
To investigate the midterm effect of exercise capacity and quality of life (QoL) of adult patients who underwent transthoracic device closure of ventricular septal defects (VSDs) and explore the gap in the quality of life and cardiopulmonary function between those patients and healthy people.
Methods
From January 2010 to January 2015, 58 adult patients who underwent transthoracic device closure of VSD and 60 healthy people matched for age and sex were selected and analyzed. Echocardiography and exercise capacity tests were performed, and the MOS 36-item short-form health survey (SF-36) was used to investigate the changes in QoL.
Results
Fifty-five patients completed the study. At the 1-year and 5-year follow-ups, the patients’ left ventricular end-systolic and end-diastolic diameters were smaller than those preoperatively, but the difference was not statistically significant. In the QoL survey, the patients’ scores after treatment showed a trend of improvement, and the improvement effect was not transient. After VSD closure, the difference in QoL between the patients and the control group was significantly reduced. However, in the exercise capacity test, the patients’ results were still worse than those of the controls.
Conclusion
Transthoracic device closure of VSDs is significant in improving adult patients’ QoL at the midterm follow-up, reflected in their physical and psychological fields. However, they are still unable to achieve normal levels of peak exercise ability. Therefore, further exploration and interventions are worth considering.
“…Volume assessment of shunt using VTI has been validated previously. 13 This study builds on clinical application of this methodology. However, we did not use intra-cardiac invasive measurements at rest/stress to justify our findings.…”
Purpose: Doppler echocardiography is a sensitive method for diagnosing ventricular septal defect (VSD). In case of bi-directional flow across VSD, we did not identify any study that used velocity time integral to access volume of shunt across VSD during rest/exercise. We identified a case of 28 year old man with bi-directional flow across VSD who presented with unexplained syncopial attacks.
Methods:We carried out an Exercise Stress Echocardiogram using WHO protocol. We used colour doppler across inter-ventricular septum to identify the VSD. Sample volume was then placed through VSD to obtain pulsed doppler images at rest and at peak exercise. We averaged all velocity time integrals (VTI) obtained for five cardiac cycles.Results: On exercise he managed stage one of the protocol and achieved 75% of maximum predicted target heart rate. His oxygenation dropped from 93% to 74% on air. However, the pulmonary systolic pressure increased from 63mmHg to 104mmHg. The contraction of the right ventricle increased appropriately with exercise. Averaged VTI at rest for left to right (L-R) shunt was 26.32cm and at stress was 21.6cm. Similarly VTI at rest for right to left shunt (R-L) was 78.08cm and at stress was 79.44cm. Absolute change of VTI ratio during exercise was equal to 0.71 (3.67-2.96). This is equal to 24% increase in ratio of VTIs during stress.
Conclusion:According to VTI assessment of bi-directional VSD there was significant worsening of right to left shunt during exercise secondary to increase pulmonary vascular resistance on exercise. This was de-stabilizing his oxygenation and led to syncopial attacks. This case highlights use of Doppler pulsed-wave echocardiography in haemodynamic assessment of bi-directional VSD.
Section: Defect In a Patient With Left Ventricular Assist Devicementioning
confidence: 99%
“…It has been reported that to-and-fro or R-L shunt in diastole was documented in some patients with VSD, who had large VSD or were accompanied by severe pulmonary hypertension. 4,5 The finding of continuous R-L shunt across morphologically small VSD without advanced pulmonary hypertension might be unique to patients with LVAD.…”
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