Bidirectional Frontoparietal Oscillatory Systems Support Working Memory

Johnson, Elizabeth L.; Dewar, Callum; Solbakk, Anne‐Kristin; Endestad, Tor; Meling, Torstein R.; Knight, Robert T.

doi:10.1016/j.cub.2017.05.046

Cited by 98 publications

(124 citation statements)

References 42 publications

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“…We did not observe an interaction of prediction and rhythmic stimulation, which implies a functional separation of top-down and bottomup systems supporting visual perception. Our results are in accordance with previous lesion studies, which indicated that high-level visual perception is PFC dependent (27,31), as well as reports suggesting that long-range endogenous delta activity may constitute a neural correlate of directed top-down control (15). For example, Johnson et al (31) reported that prefrontal damage diminished long-range top-down control that was associated with oscillatory activity in the delta-theta range (2-7 Hz).…”

Section: Discussionsupporting

confidence: 82%

Prefrontal cortex modulates posterior alpha oscillations during top-down guided visual perception

Helfrich

Huang

Wilson

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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106

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Conscious visual perception is proposed to arise from the selective synchronization of functionally specialized but widely distributed cortical areas. It has been suggested that different frequency bands index distinct canonical computations. Here, we probed visual perception on a fine-grained temporal scale to study the oscillatory dynamics supporting prefrontal-dependent sensory processing. We tested whether a predictive context that was embedded in a rapid visual stream modulated the perception of a subsequent near-threshold target. The rapid stream was presented either rhythmically at 10 Hz, to entrain parietooccipital alpha oscillations, or arrhythmically. We identified a 2-to 4-Hz delta signature that modulated posterior alpha activity and behavior during predictive trials. Importantly, deltamediated top-down control diminished the behavioral effects of bottom-up alpha entrainment. Simultaneous source-reconstructed EEG and cross-frequency directionality analyses revealed that this delta activity originated from prefrontal areas and modulated posterior alpha power. Taken together, this study presents converging behavioral and electrophysiological evidence for frontal deltamediated top-down control of posterior alpha activity, selectively facilitating visual perception.top-down control | directional cross-frequency coupling | prefrontal cortex | alpha oscillations | phase-amplitude coupling V isual perception is flexible, selective, and rapidly integrates sensory evidence with endogenous high-level expectations and predictions (1, 2). It has been suggested that rhythmic brain activity constitutes a key mechanism to coordinate information flow in the human cerebral cortex by transiently forming task-relevant largescale networks (1). However, it is currently unclear how contextual information is dynamically integrated to support visual perception. Numerous studies have shown that visual perception critically depends on prestimulus alpha-band (8-12 Hz) activity (3-7). The gating-by-inhibition hypothesis postulates that alpha serves as a mechanism to route information to task-relevant cortical sites (8) but might also be under top-down control (6, 7). However, it is currently unclear which cortical regions and mechanisms mediate the directed top-down control of alpha oscillations (2). It has been suggested that slow-frequency activity in the delta range (<5 Hz) might reflect a mechanism for endogenous attentional selection and predictions (9, 10). In particular, endogenous low-frequency entrainment is thought to reflect a substrate of top-down processing (11)(12)(13)(14). Importantly, endogenous entrainment does not require rhythmicity in the input stream but reflects an intrinsic mechanism to enable predictions (15). Several studies have demonstrated that visual perception cycles as a function of the alpha phase but only a few reports have demonstrated that multiple rhythms modulate behavior on a fine-grained temporal scale (5,(16)(17)(18)(19).At present, it is uncertain how different temporal scales interact t...

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Section: Discussionsupporting

confidence: 82%

Prefrontal cortex modulates posterior alpha oscillations during top-down guided visual perception

Helfrich

Huang

Wilson

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

106

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“…Frontal and parietal networks are emerging as important circuits for working memory and attention, and their absence is noteworthy. 41 The frontal abnormality is well appreciated in JME but disconnection to the parietal region has not been noted previously and may represent another underappreciated network deficit in JME that contributes to the wellknown dysexecutive function. [4][5][6] Furthermore, the identified widespread network disruptions may be contributed to the increasingly recognized generalized cognitive dysfunction, 7 increased rate of psychiatric complications, 8 and problematic long-term social function and employment status.…”

Section: Network Hubsmentioning

confidence: 86%

Progressive dissociation of cortical and subcortical network development in children with new‐onset juvenile myoclonic epilepsy

Garcia‐Ramos

Dabbs²,

Lin

et al. 2018

Epilepsia

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Objectives: Structural and functional MRI studies have consistently documented cortical and subcortical abnormalities in patients with Juvenile Myoclonic Epilepsy (JME). However, little is known about how these structural abnormalities emerge from the time of epilepsy onset and how network interactions between and within cortical and subcortical regions may diverge in youth with JME compared to typically developing children. Methods: We examined prospective co-variations of volumetric differences derived from high resolution structural MRI during the first two years of epilepsy diagnosis in a group of youth with JME (n=21) compared to healthy controls (n=22). We indexed developmental brain changes using graph theory by computing network metrics based on the correlation of the cortical and subcortical structural covariance near the time of epilepsy and two years later. Results: Over two years, normally developing children showed modular cortical development and network integration between cortical and subcortical regions. In contrast, children with JME developed a highly correlated and less modular cortical network, which was atypically dissociated from subcortical structures. Furthermore, the JME group also presented higher clustering and lower modularity indices than controls, indicating weaker modules or communities. The local efficiency in JME was higher than controls across the majority of cortical nodes. Regarding network hubs, controls presented a higher number than youth with JME that were spread across the brain with ample representation from the different modules. In contrast, children with JME showed a lower number of hubs that were mainly from one module and were comprised mostly of subcortical structures. Significance: Youth with JME prospectively developed a network of highly correlated cortical regions dissociated from subcortical structures during the first 2 years of epilepsy onset. The cortical-subcortical network dissociation provides converging insights on the disparate literature of cortical and subcortical abnormalities found in previous studies.

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“…Specifically, alpha oscillatory activity exerts inhibitory influences on sensory cortical neuronal firing and excitation (Foxe & Snyder, 2011;Jensen & Bonnefond, 2013;Klimesch, Sauseng, & Hanslmayr, 2007). Furthermore, via long-range, posteriorfrontal projections, alpha oscillations mediate inhibitory bottom-up information flow from the sensory cortex to frontal regions to influence global neural activity (Hillebrand, et al, 2016;Johnson, et al, 2017;Sadaghiani & Kleinschmidt, 2016;Tang, et al, 2007). This long-range alpha connectivity plays a critical role in gating the entry of sensory input into downstream processing and, eventually, conscious awareness, thereby regulating perception, imagery, and working memory (Doesburg, Green, McDonald, & Ward, 2009;Jensen, Bonnefond, & VanRullen, 2012;Mathewson, et al, 2011;Samaha, Boutonnet, Postle, & Lupyan, 2018;Samaha & Postle, 2015).…”

Section: Introductionmentioning

confidence: 99%

Intrinsic sensory disinhibition contributes to intrusive re-experiencing in combat veterans

Clancy

Albizu

Schmidt

et al. 2019

Preprint

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Word count -Main Text: 3585 (no citations) Word count -Abstract: 225 Number of Figures: 5 Number of Tables: 1 Clancy et al. Sensory disinhibition and intrusive re-experiencing 2 HIGHLIGHTS • Alpha oscillations (indexing sensory inhibition) measured in 86 combat veterans • Re-experiencing symptom severity was associated with attenuated alpha connectivity • Trauma memory for, not emotional response to, odors mediated this relationship • Trauma memories may arise via disinhibited activation of sensory representations • Sensory systems may be novel target for intrusive re-experiencing symptom treatment Clancy et al. Sensory disinhibition and intrusive re-experiencing 3 ABSTRACTIntrusive re-experiencing of traumatic events is a hallmark symptom of posttraumatic stress disorder (PTSD). In contrast to abstract, verbal intrusions in other affective disorders, intrusive re-experiencing in PTSD is characterized by vivid sensory details as "flashbacks". While prevailing PTSD models largely focus on dysregulated emotional processes, we hypothesize that deficient sensory inhibition in PTSD could drive overactivation of sensory representations of trauma memories, precipitating sensory-rich intrusions of trauma. In 86 combat veterans, we examined resting-state alpha (8-12 Hz) oscillatory activity (in both power and posteriorfrontal connectivity), given its key role in sensory cortical inhibition, in association with intrusive reexperiencing symptoms. A subset (N = 35) of veterans further participated in an odor task (including both combat and non-combat odors) to assess olfactory trauma memory and emotional response. We observed a strong association between intrusive re-experiencing symptoms and attenuated resting-state posteriorfrontal alpha connectivity, which were both correlated with olfactory trauma memory (but not emotional response). Importantly, olfactory trauma memory was further identified as a full mediator of the relationship between alpha connectivity and intrusive re-experiencing in these veterans, suggesting that deficits in intrinsic sensory inhibition can contribute to intrusive re-experiencing of trauma via heightened trauma memory. Therefore, by permitting unfiltered sensory cues to enter information processing and spontaneously activating sensory representations of trauma, impaired sensory inhibition can constitute a sensory mechanism of intrusive re-experiencing in PTSD.

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Bidirectional Frontoparietal Oscillatory Systems Support Working Memory

Cited by 98 publications

References 42 publications

Prefrontal cortex modulates posterior alpha oscillations during top-down guided visual perception

Prefrontal cortex modulates posterior alpha oscillations during top-down guided visual perception

Progressive dissociation of cortical and subcortical network development in children with new‐onset juvenile myoclonic epilepsy

Intrinsic sensory disinhibition contributes to intrusive re-experiencing in combat veterans

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