Bidirectional isotachophoresis on a planar chip with integrated conductivity detection

Prest, Jeff E.; Baldock, Sara J.; Fielden, Peter R.; Goddard, N J; Brown, Bernard J. Treves

doi:10.1039/b207462a

Cited by 46 publications

(44 citation statements)

References 35 publications

(45 reference statements)

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“…ITP [89][90][91][92] has also been used with conductivity detection as a separation technique either alone or in conjunction with CZE [86,88]. This technique has been used for a variety of applications including the isolation of the drug valproic acid from human serum [87].…”

Section: Figure 12mentioning

confidence: 98%

Recent developments in electrochemical detection for microchip capillary electrophoresis

et al. 2004

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Significant progress in the development of miniaturized microfluidic systems has occurred since their inception over a decade ago. This is primarily due to the numerous advantages of microchip analysis, including the ability to analyze minute samples, speed of analysis, reduced cost and waste, and portability. This review focuses on recent developments in integrating electrochemical (EC) detection with microchip capillary electrophoresis (CE). These detection modes include amperometry, conductimetry, and potentiometry. EC detection is ideal for use with microchip CE systems because it can be easily miniaturized with no diminution in analytical performance. Advances in microchip format, electrode material and design, decoupling of the detector from the separation field, and integration of sample preparation, separation, and detection on-chip are discussed. Microchip CEEC applications for enzyme/immunoassays, clinical and environmental assays, as well as the detection of neurotransmitters are also described.

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Section: Figure 12mentioning

confidence: 98%

Recent developments in electrochemical detection for microchip capillary electrophoresis

et al. 2004

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“…The group used 10 mM HCl buffered to a pH of 3.6 with glycylglycine as the anolyte and 12.5 mM Cs 2 CO 3 as the catholyte. This enabled them to separate a mixture containing 10 mM of each of the above-mentioned salts [42].…”

Section: Determination Of Ions By Itp On Chipsmentioning

confidence: 99%

Determination of inorganic ions using microfluidic devices

et al. 2004

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The separation and detection of inorganic ions on microfluidic devices has received little attention since the 'lab-on-a-chip' concept has revolutionised the field of electrokinetically driven analysis. This review presents a summary and discussion of the published literature on inorganic analysis using microfluidic devices and includes sections on electromigration separation methods, namely isotachophoresis (ITP), capillary electrophoresis (CE), and hyphenated ITP-CE, together with a brief account of flow injection analysis. The review concludes with the authors' perspective on future directions for inorganic analysis on microfluidic devices.

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“…Examples include, moulding [53][54][55][56][57][58], injection moulding [59][60][61], hot embossing [11,62], micromachining [63], milling [42,64,65] and screen printing [53,66].…”

Section: Typical Fabrication Methods For Microfluidic Chipsmentioning

confidence: 99%

“…ITP cannot separate a sample containing both anions and cations in a single run. Prest et al [42] and Hirokawa et al [43] have conducted work on bi-directional ITP. Here, the researchers moved the ions in two directions along the channel using different methods; Prest's group injected the mixture into the middle of a channel along which an electric field was applied.…”

Section: Isotachophoresismentioning

confidence: 99%

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Review on the development of truly portable andin-situcapillary electrophoresis systems

Lewis

Cranny

Harris

et al. 2013

Meas. Sci. Technol.

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Capillary electrophoresis (CE) is a technique which uses an electric field to separate a mixed sample into its constituents. Portable CE systems enable this powerful analysis technique to be used in the field. Many of the challenges for portable systems are similar to those of autonomous in-situ analysis and therefore portable systems may be considered a stepping stone towards autonomous in-situ analysis. CE is widely used for biological and chemical analysis and example applications include: water quality analysis; drug development and quality control; proteomics and DNA analysis; counter-terrorism (explosive material identification) and corrosion monitoring. The technique is often limited to laboratory use, since it requires large electric fields, sensitive detection systems and fluidic control systems. All of these place restrictions in terms of: size, weight, cost, choice of operating solutions, choice of fabrication materials, electrical power and lifetime. In this review we bring together and critique the work by researchers addressing these issues. We emphasize the importance of a holistic approach for portable and in-situ CE systems and discuss all the aspects of the design. We identify gaps in the literature which require attention for the realization of both truly portable and in-situ CE systems.

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Bidirectional isotachophoresis on a planar chip with integrated conductivity detection

Cited by 46 publications

References 35 publications

Recent developments in electrochemical detection for microchip capillary electrophoresis

Recent developments in electrochemical detection for microchip capillary electrophoresis

Determination of inorganic ions using microfluidic devices

Review on the development of truly portable andin-situcapillary electrophoresis systems

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